N6,N6'-di(quinolin-6-yl)-[2,2'-bipyridine]-6,6'-dicarboxamide | 929895-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N6,N6'-di(quinolin-6-yl)-[2,2'-bipyridine]-6,6'-dicarboxamide
• CAS: 929895-48-7
• 化学式: C₃₀H₂₀N₆O₂
• 分子量: 496.528
• InChiKey: FJILCIYOQGYYTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.74
• 重原子数：
  38.0
• 可旋转键数：
  5.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109.76
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N6,N6'-di(quinolin-6-yl)-[2,2'-bipyridine]-6,6'-dicarboxamide 、 三氟甲烷磺酸甲酯 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds

  摘要：

  Syntheses and telomeric G-quadruplex-DNA binding properties of novel bisquinolinium compounds are reported. This series exhibits remarkable efficiency both in terms of stabilization and selectivity, thus combining the performances of the most potent quadruplex binders reported so far. These bisquinolinium compounds then represent an ideal tradeoff between rapid synthetic access and efficient target recognition. The study also highlights important structural parameters that lead to the design of highly selective G-quadruplex binders.

  DOI：

  10.1021/ja067352b
• 作为产物：
  描述：

  6,6'-二甲基-2,2'-联吡啶 在 N-羟基-7-氮杂苯并三氮唑 potassium permanganate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 N6,N6'-di(quinolin-6-yl)-[2,2'-bipyridine]-6,6'-dicarboxamide
  参考文献：
  名称：

  Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds

  摘要：

  Syntheses and telomeric G-quadruplex-DNA binding properties of novel bisquinolinium compounds are reported. This series exhibits remarkable efficiency both in terms of stabilization and selectivity, thus combining the performances of the most potent quadruplex binders reported so far. These bisquinolinium compounds then represent an ideal tradeoff between rapid synthetic access and efficient target recognition. The study also highlights important structural parameters that lead to the design of highly selective G-quadruplex binders.

  DOI：

  10.1021/ja067352b