N-(2-chloro-4-methylquinolin-6-yl)-2-(4-trifluoromethylphenoxy)acetamide | 744220-34-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-chloro-4-methylquinolin-6-yl)-2-(4-trifluoromethylphenoxy)acetamide
• 英文别名: N-(2-chloro-4-methylquinolin-6-yl)-2-[4-(trifluoromethyl)phenoxy]acetamide
• CAS: 744220-34-6
• 化学式: C₁₉H₁₄ClF₃N₂O₂
• 分子量: 394.781
• InChiKey: HVCMTWRVVXCREQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  吡啶-4-硼酸 、 N-(2-chloro-4-methylquinolin-6-yl)-2-(4-trifluoromethylphenoxy)acetamide 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride caesium carbonate 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 0.4h， 生成 N-[4-methyl-2-(4-pyridyl)quinolin-6-yl]-2-[4-(trifluoromethyl)phenoxy]acetamide
  参考文献：
  名称：

  [EN] SUBSTITUTED QUINOLINES AS MCR MODULATORS
  [FR] QUINOLEINES SUBSTITUEES, UTILISEES COMME MODULATEURS DE LA MCH

  摘要：

  式(I)的喹啉在MCH介质和肥胖治疗中很有用。

  公开号：

  WO2005035521A1
• 作为产物：
  描述：

  2-氯-4-甲基-6-硝基喹啉 在 盐酸 、 铁粉 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-(2-chloro-4-methylquinolin-6-yl)-2-(4-trifluoromethylphenoxy)acetamide
  参考文献：
  名称：

  Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

  摘要：

  A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.051

文献信息

• Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists
  作者：Rosa Arienzo、David E Clark、Sue Cramp、Stephen Daly、Hazel J Dyke、Peter Lockey、Dennis Norman、Alan G Roach、Keith Stuttle、Maxine Tomlinson、Melanie Wong、Stephen P Wren

  DOI：10.1016/j.bmcl.2004.05.051

  日期：2004.8

  A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors. (C) 2004 Elsevier Ltd. All rights reserved.
• [EN] SUBSTITUTED QUINOLINES AS MCR MODULATORS<br/>[FR] QUINOLEINES SUBSTITUEES, UTILISEES COMME MODULATEURS DE LA MCH
  申请人：ARGENTA DISCOVERY LTD

  公开号：WO2005035521A1

  公开（公告）日：2005-04-21

  Quinolines of formula (I) are useful as MCH mediators, and in the therapy of obesity.

  式(I)的喹啉在MCH介质和肥胖治疗中很有用。