Salvinorinyl-2-bromide | 874624-29-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Salvinorinyl-2-bromide
• 英文别名: (2S,4aR,6aR,7R,9R,10aS,10bR)-9-(bromo)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]-pyran-7-carboxylic acid methyl ester；(2S,4aS,6aR,7R,9R,10aS,10bR)-9-(bromo)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester；(3S,4aR,4bS,6R,8R,8aR,10aR)-6-Bromo-3-furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester；methyl (2S,4aR,6aR,7R,9R,10aS,10bR)-9-bromo-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate
• CAS: 874624-29-0
• 化学式: C₂₁H₂₅BrO₆
• 分子量: 453.33
• InChiKey: SHPQMCUDHJJTAU-GKRPYSMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  82.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Salvinorinyl-2-bromide 在 35S-potassium thioacetate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以66%的产率得到35S-salvinorinyl-2-thioacetate
  参考文献：
  名称：

  [EN] AGENTS WITH SELECTIVE K-OPIOID RECEPTOR AFFINITY
  [FR] AGENTS PRESENTANT UNE AFFINITE SELECTIVE POUR LE RECEPTEUR OPIOIDE K

  摘要：

  公开号：

  WO2006012643A3
• 作为产物：
  描述：

  SALVINORINB(品牌:CAYMAN进口) 在 吡啶 、 二溴亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以33%的产率得到Salvinorinyl-2-bromide
  参考文献：
  名称：

  Stewart, D. Jeremy; Fahmy, Hesham; Roth, Bryan L., Arzneimittel-Forschung/Drug Research, 2006, vol. 56, # 4, p. 269 - 275

  摘要：

  DOI：

文献信息

• Opioid receptor ligands and methods for their preparation
  申请人：Prisinzano Thomas

  公开号：US20060058264A1

  公开（公告）日：2006-03-16

  The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. The invention also provides an improved method for isolating intermediate materials useful for obtaining compounds of formula I.

  该发明提供了公式I的新化合物，这些化合物是阿片受体配体。该发明还提供了包含这些化合物的药物组合物，以及通过向需要治疗的哺乳动物施用这些化合物来治疗与阿片受体功能相关的疾病的方法。该发明还提供了一种改进的方法，用于分离中间体材料，以获得公式I的化合物。
• Herkinorin Analogues with Differential β-Arrestin-2 Interactions
  作者：Kevin Tidgewell、Chad E. Groer、Wayne W. Harding、Anthony Lozama、Matthew Schmidt、Alfred Marquam、Jessica Hiemstra、John S. Partilla、Christina M. Dersch、Richard B. Rothman、Laura M. Bohn、Thomas E. Prisinzano

  DOI：10.1021/jm701162g

  日期：2008.4.1

  Salvinorin A is a psychoactive natural product that has been found to be a potent and selective kappa opioid receptor agonist in vitro and in vivo. The activity of salvinorin A is unusual compared to other opioids such as morphine in that it mediates potent kappa opioid receptor signaling yet leads to less receptor downregulation than observed with other kappa agonists. Our initial chemical modifications of salvinorin A have yielded one analogue, herkinorin (1c), with high affinity at the mu OR. We recently reported that 1c does not promote the recruitment of beta-arrestin-2 to the mu OR or receptor internalization. Here we describe three new derivatives of 1c (3c, 3f, and 3i) with similar properties and one, benzamide 7b, that promotes recruitment of beta-arrestin-2 to the mu OR and receptor internalization. When the important role mu opioid receptor regulation plays in determining physiological responsiveness to opioid narcotics is considered,mu opioids derived from salvinorin A may offer a unique template for the development of functionally selective mu opioid receptor-ligands with the ability to produce analgesia while limiting adverse side effects.
• US7687538B2
  申请人：——

  公开号：US7687538B2

  公开（公告）日：2010-03-30
• Stewart, D. Jeremy; Fahmy, Hesham; Roth, Bryan L., Arzneimittel-Forschung/Drug Research, 2006, vol. 56, # 4, p. 269 - 275
  作者：Stewart, D. Jeremy、Fahmy, Hesham、Roth, Bryan L.、Yan, Feng、Zjawiony, Jordan K.

  DOI：——

  日期：——
• [EN] AGENTS WITH SELECTIVE K-OPIOID RECEPTOR AFFINITY<br/>[FR] AGENTS PRESENTANT UNE AFFINITE SELECTIVE POUR LE RECEPTEUR OPIOIDE K
  申请人：UNIV MISSISSIPPI

  公开号：WO2006012643A3

  公开（公告）日：2006-06-22