2,5-di[5-(3-tert-butyl-2-hydroxybenzaldehyde)]thiophene | 1256124-09-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-di[5-(3-tert-butyl-2-hydroxybenzaldehyde)]thiophene
• 英文别名: 3-Tert-butyl-5-[5-(3-tert-butyl-5-formyl-4-hydroxyphenyl)thiophen-2-yl]-2-hydroxybenzaldehyde；3-tert-butyl-5-[5-(3-tert-butyl-5-formyl-4-hydroxyphenyl)thiophen-2-yl]-2-hydroxybenzaldehyde
• CAS: 1256124-09-0
• 化学式: C₂₆H₂₈O₄S
• 分子量: 436.572
• InChiKey: IBAAIQAMBXOPJV-UHFFFAOYSA-N

物化性质

• 熔点：
  135 °C
• 沸点：
  522.1±50.0 °C(predicted)
• 密度：
  1.202±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-叔丁基苯酚 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 四(三苯基膦)钯 、 溴 、 potassium acetate 、 potassium carbonate 、 三乙胺 、 magnesium chloride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙二醇二甲醚 、 水 、 溶剂黄146 为溶剂， 反应 61.0h， 生成 2,5-di[5-(3-tert-butyl-2-hydroxybenzaldehyde)]thiophene
  参考文献：
  名称：

  Synthesis and characterization of original calix–salen type ligands

  摘要：

  Polycondensation reactions between various modified disalicylaldehyde derivatives and two chiral diamines afforded in each case macrocyclic structures, named calix-salen. Mixtures of oligomers (dimers to pentamers) were qualitatively analyzed by Maldi-Tof and H-1 NMR DOSY experiments allowed their easy quantitative investigation. Tuning the reaction conditions and namely the concentration of both monomeric partners led interestingly to the selective preparation of the dimer or the tetramer as main products, in diluted or concentrated media, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.09.077

文献信息

• New Chiral Calixsalen Chromium Complexes: Recyclable Asymmetric Catalysts
  作者：Anaïs Zulauf、Mohamed Mellah、Emmanuelle Schulz

  DOI：10.1002/chem.201001012

  日期：——

  ylenediamine (salen) polymer has been prepared by a condensation reaction between a thiophenedisalicyladehyde derivative and (S,S)‐cyclohexane‐1,2‐diamine. This polymeric compound was demonstrated to possess a cyclic structure with two to five repetitive units. The addition of chromium(II) salts led to the generation of a chiral catalyst that could be recovered as an insoluble powder. The performance

  的手性Ñ，Ñ ' -双（亚水杨基）乙二胺（沙仑）聚合物已经制备由thiophenedisalicyladehyde衍生物和（之间的缩合反应小号，小号）-环己烷-1,2-二胺。证明该聚合化合物具有带有两个至五个重复单元的环状结构。铬（II）盐的添加导致手性催化剂的产生，该手性催化剂可以以不溶性粉末的形式回收。在各种转化中，特别是在异质条件下促进亲核环氧化物开环的能力中，检验了这种新型杯盖型催化剂的性能。与通过使用类似的线性聚合物获得的目标产物相比，以高收率和改进的选择性获得了目标产物。环状结构中催化位点的排列可能更适合于这种苛刻反应的必要的协同双金属途径。该催化剂可以成功地再循环。
• Synthesis and characterization of original calix–salen type ligands
  作者：Farah Ibrahim、Houssein Nasrallah、Xiang Hong、Mohamed Mellah、Ali Hachem、Ghassan Ibrahim、Nada Jaber、Emmanuelle Schulz

  DOI：10.1016/j.tet.2012.09.077

  日期：2012.12

  Polycondensation reactions between various modified disalicylaldehyde derivatives and two chiral diamines afforded in each case macrocyclic structures, named calix-salen. Mixtures of oligomers (dimers to pentamers) were qualitatively analyzed by Maldi-Tof and H-1 NMR DOSY experiments allowed their easy quantitative investigation. Tuning the reaction conditions and namely the concentration of both monomeric partners led interestingly to the selective preparation of the dimer or the tetramer as main products, in diluted or concentrated media, respectively. (C) 2012 Elsevier Ltd. All rights reserved.