2-hydrazino-5,7-dichloro-8-quinolinol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-hydrazino-5,7-dichloro-8-quinolinol
• 英文别名: 5,7-Dichloro-2-hydrazinylquinolin-8-ol
• 化学式: C₉H₇Cl₂N₃O
• mdl: MFCD00552679
• 分子量: 244.08
• InChiKey: GEMKVFRCPIKGPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-甲基呋喃醛 、 2-hydrazino-5,7-dichloro-8-quinolinol 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以54%的产率得到5,7-Dichloro-2-[2-[(5-methylfuran-2-yl)methylidene]hydrazinyl]quinolin-8-ol
  参考文献：
  名称：

  Tetradentate 5,7-dichloro-8-hydroxy-2-quinolylhydrazones

  摘要：

  Chromogenic tetradentate 5,7-dichloro-8-hydroxy-2-quinolylhydrazones of 5-methylfurfural, 2-thiophenecarboxaldehyde, and phenylglyoxylic acid have been prepared. Mass spectrometry data of the prepared hydrazones are presented. Spectral properties of the prepared products and their chromogenic reactions with selected heavy metal ions have been studied. High selectivity of the hydrazone of 5-methylfurfural with respect to lead ion has been demonstrated.

  DOI：

  10.1134/s1070363215030159
• 作为产物：
  描述：

  2,5,7-三氯-8-喹啉醇 生成 2-hydrazino-5,7-dichloro-8-quinolinol
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• ——
  作者：OSTROVSKAYA V. M.、 KRASAVIN I. A.、 INSHAKOVA V. A.、 MAMAEV V. P.、 KRIVOPA+

  DOI：——

  日期：——
• KRASAVIN I. A.; INSHAKOVA V. A.; VYSOKOVA N. N.; PARUSNIKOV B. V.; OSTROV+, PERSPEKTIVY RASSHIRENIYA ASSORTIMENTA XIM. REAKTIVOV DLYA OBESPECH. POTRE+
  作者：KRASAVIN I. A.、 INSHAKOVA V. A.、 VYSOKOVA N. N.、 PARUSNIKOV B. V.、 OSTROV+

  DOI：——

  日期：——
• Antimicrobial Compounds
  申请人：Moy Terence

  公开号：US20120232110A1

  公开（公告）日：2012-09-13

  This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections.
• US9241928B2
  申请人：——

  公开号：US9241928B2

  公开（公告）日：2016-01-26
• Tetradentate 5,7-dichloro-8-hydroxy-2-quinolylhydrazones
  作者：V. M. Ostrovskaya、A. K. Buryak、A. S. Peregudov、A. V. Ul’yanov

  DOI：10.1134/s1070363215030159

  日期：2015.3

  Chromogenic tetradentate 5,7-dichloro-8-hydroxy-2-quinolylhydrazones of 5-methylfurfural, 2-thiophenecarboxaldehyde, and phenylglyoxylic acid have been prepared. Mass spectrometry data of the prepared hydrazones are presented. Spectral properties of the prepared products and their chromogenic reactions with selected heavy metal ions have been studied. High selectivity of the hydrazone of 5-methylfurfural with respect to lead ion has been demonstrated.