喹啉-2-基乙酸酯 | 30074-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 喹啉-2-基乙酸酯
• 英文名称: 2-Acetoxychinolin
• 英文别名: 2-Quinolinol, acetate (ester)；quinolin-2-yl acetate
• CAS: 30074-79-4
• 化学式: C₁₁H₉NO₂
• 分子量: 187.198
• InChiKey: CNNBEXYIRHCJBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  喹啉-2-基乙酸酯 在 水 作用下， 反应 0.5h， 生成 2-喹啉醇
  参考文献：
  名称：

  Oxygenation of the Unactivated Pyridine System by Acetyl Hypofluorite Made Directly from F2

  摘要：

  DOI：

  10.3987/com-88-s5
• 作为产物：
  描述：

  喹啉 在 双氧水 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 36.0h， 生成 喹啉-2-基乙酸酯
  参考文献：
  名称：

  高价碘（III）介导的喹啉N-氧化物与三甲基甲硅烷基氰化物的区域选择性氰化

  摘要：

  在无金属和无碱反应条件下，使用（二乙酰氧基碘）苯（PIDA）作为介导的高价碘（III）试剂，开发了用三甲基甲硅烷基氰化喹啉N-氧化物的区域选择性氰化反应，从而获得2-氰基喹啉。高效的PIDA试剂可以起到底物的活化剂和N-O键断裂促进剂的作用。该反应系统具有广泛的底物适用性和高收率的特点。该程序以克级放大以合成结核病（TB）抑制剂。最后，根据一些实验结果，提出了合理的氰化反应机理。

  DOI：

  10.1002/adsc.201801185

文献信息

• 2-Phenyl-quinoline derivatives, preparation method and therapeutic use thereof
  申请人：——

  公开号：US20030097000A1

  公开（公告）日：2003-05-22

  Compounds of general formula (I) 1 in which: A represents a hydrogen atom or a hydroxyl, B represents a hydrogen atom or a C 1-3 alkyl group, R 1 represents a phenyl optionally substituted with a halogen, a hydroxyl, a C 1-3 alkoxy, C 1-3 alkyl, C 1-3 fluoroalkyl or C 1-2 perfluoroalkyl group, R 2 , R 3 and R 6 , which may be identical or different, each represent a hydrogen atom, a halogen, a C 1-6 alkyl or C 2-6 alkenyl group, R 4 and R 5 , which may be identical or different, each represent a hydrogen atom, a C 1-6 alkyl, C 2-6 alkenyl or C 3-6 cycloalkyl group, or R 4 and R 5 together form a C 2-6 alkylene or C 3-6 alkenylene chain to give, with the nitrogen to which they are attached, a heterocycle, this heterocycle optionally being substituted with a C 1-4 alkyl group. Therapeutic use.

  通式（I）的化合物，其中：A代表氢原子或羟基，B代表氢原子或C1-3烷基基团，R1代表苯基，可选择地取代卤素、羟基、C1-3烷氧基、C1-3烷基、C1-3氟代烷基或C1-2全氟代烷基基团，R2、R3和R6可以相同也可以不同，每个代表氢原子、卤素、C1-6烷基或C2-6烯基基团，R4和R5可以相同也可以不同，每个代表氢原子、C1-6烷基、C2-6烯基或C3-6环烷基，或者R4和R5一起形成C2-6烷基亚或C3-6烯基亚链，与它们连接的氮原子形成杂环，这种杂环可选择地取代C1-4烷基基团。治疗用途。
• Substituted imidazolinyl nicotine acids, esters and salts and use thereof as herbicidal agents
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0041623A2

  公开（公告）日：1981-12-16

  There are provided novel 2-(2-imidazolin-2-yl)pyridine and quinoline compounds, a process and intermediate compounds forthe preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.

  本文提供了新型 2-(2-咪唑啉-2-基)吡啶和喹啉化合物、其制备工艺和中间体化合物，以及用其控制多种一年生和多年生植物物种的方法。
• Method to beneficially influence & alter the development & life cycle of agronomic and horticultural crops with certain imidazolinyl nicotinic acids and derivatives thereof
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0041624A2

  公开（公告）日：1981-12-16

  There is provided a method for increasing axillary branching, tillering, flowering, and yield of agronomic and horticultural crops, by applying to said crop plants or to soil containing the seeds or other propagating organs of said plants, an effective amount of a 2-(2-imidazolin-2-yl)pyridine or 2-(2-imidazolin-2-yl)quinoline derivative.

  本发明提供了一种增加农艺和园艺作物腋枝、分蘖、开花和产量的方法，该方法是将有效量的 2-(2-咪唑啉-2-基)吡啶或 2-(2-咪唑啉-2-基)喹啉衍生物施用于所述作物植株或含有所述植株种子或其他繁殖器官的土壤中。
• Liquid crystal copolyesters having a blocked terminal of its molecular chain
  申请人：POLYPLASTICS CO. LTD.

  公开号：EP0269321A2

  公开（公告）日：1988-06-01

  A liquid crystal copolyester having at its terminal a blocked molecular chain. The liquid crystal copolyester comprising a copolyester which exhibits anisotropy in a molten state and which has a functional group located at the terminal of its molecular chain and which is blocked with a low-molecular compound which includes at least one aromatic ring and which has a molecular weight of 350 or less.

  一种液晶共聚聚酯，其分子链末端被封堵。 该液晶共聚聚酯包括一种共聚聚酯，该共聚聚酯在熔融状态下表现出各向异性，其分子链末端有一个官能团，并被一种低分子化合物封堵，该化合物至少包括一个芳香环，分子量在 350 或以下。
• Utilizing acetyl hypofluorite for chlorination, bromination, and etherification of the pyridine system
  作者：David Hebel、Shlomo Rozen

  DOI：10.1021/jo00022a016

  日期：1991.10

  Acetyl hypofluorite, which is easily made from F2, possesses a strong electrophilic fluorine. This electrophile is able to attach itself to the nitrogen atom of pyridine and activate the ring toward nucleophilic attacks. The ultimate elimination of HF results in an overall easy nucleophilic displacement of the hydrogen of the important 2-position. The nucleophiles used; Cl-delta-, Br-delta-, and RO-delta-, originate from solvents such as CH2Cl2, CH2Br2, and various primary alcohols. Thus, 2-halo- or 2-alkoxypyridines were formed. The reaction conditions (room temperature, very short reaction times, and good yields) transform the task of direct substitution of the pyridine ring from an extremely difficult to a very easy procedure.