6-<4-(3,4-dimethoxybenzoyl)-1-piperazinylcarbonyl>-3,4-dihydro-2(1H)-quinolinone | 83734-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinylcarbonyl>-3,4-dihydro-2(1H)-quinolinone
• 英文别名: 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinylcarbonyl]-3,4-dihydrocarbostyril；6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinylcarbony]-3,4-dihydrocarbostyril；6-[4-(3,4-dimethoxybenzoyl)piperazine-1-carbonyl]-3,4-dihydro-1H-quinolin-2-one
• CAS: 83734-65-0
• 化学式: C₂₃H₂₅N₃O₅
• 分子量: 423.469
• InChiKey: GCHAVGULYPPIHQ-UHFFFAOYSA-N

物化性质

• 熔点：
  238-239.5 °C(Solv: ethanol (64-17-5); chloroform (67-66-3))
• 沸点：
  719.8±60.0 °C(Predicted)
• 密度：
  1.283±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-羰基-1 ,2,3,4-四氢喹啉-6-羧酸 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinylcarbonyl>-3,4-dihydro-2(1H)-quinolinone
  参考文献：
  名称：

  Studies on positive inotropic agents. II. Synthesis of (4-substituted 1-piperazinylcarbonyl)-2-(1H)-quinolinone derivatives.

  摘要：

  合成了多种(1-哌嗪基羰基)-2(1H)-喹啉酮衍生物，并对其在犬心脏上的正性肌力活性进行了检查。其中，3, 4-二氢-6-[4-(3-氧代-3-苯基丙基)-1-哌嗪基羰基]-2(1H)-喹啉酮 (XXIj) 和 3, 4-二氢-6-[4-(氧代-4-苯基丁基)-1-哌嗪基羰基]-2(1H)-喹啉酮 (XXIl) 被发现具有强效活性。

  DOI：

  10.1248/cpb.34.682

文献信息

• Morpholino and oxazoline substituted carbostyril derivatives, process
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US04454130A1

  公开（公告）日：1984-06-12

  Novel carbostyril derivatives and their pharmaceutically acceptable salts represented by the formula (1). ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group, R.sup.2 and R.sup.3 form, together with the adjacent nitrogen atom and further with an additional oxygen atom, a 5- or 6-membered saturated heterocyclic ring which may have a lower alkyl group or a phenyl-lower alkyl group as the substituent; the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton being a single or double bond. The derivatives are useful as the active ingredient in cardiotonic compositions.

  新型的羧基喹啉衍生物及其药用盐，由下式（1）所表示。其中R.sup.1为氢原子、较低的烷基基团、较低的烯基基团、较低的炔基基团或苯基-较低的烷基基团，R.sup.2和R.sup.3与相邻的氮原子以及另外一个氧原子一起形成一个5-或6-成员的饱和杂环环，该环可能具有较低的烷基基团或苯基-较低的烷基基团作为取代基；在羧基喹啉骨架的3-和4-位置之间的碳-碳键为单键或双键。这些衍生物可用作心力衰竭组合物中的活性成分。
• Carbostyril derivatives, process for producing the same and cardiotonic
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US04468402A1

  公开（公告）日：1984-08-28

  Novel carbostyril derivatives and their pharmaceutically acceptable salts represented by the formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group; R.sup.2 and R.sup.3 may be the same or different and each is a lower alkyl group which may have one hydroxy group or one halogen atom as the substituent, or a phenyl-lower alkyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring, or said phenyl-lower allkyl group may have a lower alkylenedioxy group as the substituent on the phenyl ring; further R.sup.2 and R.sup.3 may form, together with the adjacent nitrogen and without an additional hetero-atom, a 5-or 6 membered saturated heterocyclic ring which may have a lower alkyl group or a phenyl-lower alkyl group as the substituent; the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton being a single or double bond. The derivatives are useful as the active ingredient in cardiotonic compositions.

  新型的羧基苯丙酰衍生物及其药学上可接受的盐，其化学式为(I) ##STR1## 其中R.sup.1是氢原子、低级烷基、低级烯基、低级炔基或苯基-低级烷基；R.sup.2和R.sup.3可以相同也可以不同，每个都是低级烷基，可能具有一个羟基或一个卤素原子作为取代基，或者是苯基-低级烷基，可能在苯环上有1-3个取代基，所选取代基来自低级烷氧基和卤素原子的群，或者所述苯基-低级烷基可能具有低级烷基二氧基基团作为苯环上的取代基；此外，R.sup.2和R.sup.3可以与相邻的氮原子一起形成一个5-或6-成员饱和杂环，该杂环可能具有低级烷基或苯基-低级烷基作为取代基；羧基苯丙酰骨架中3-和4-位置之间的碳-碳键可以是单键或双键。这些衍生物在心脏强效药物组合物中作为活性成分是有用的。
• Carbostyril derivatives and their salts
  申请人：Otsuka Pharmaceutical Co. Ltd.

  公开号：US04487772A1

  公开（公告）日：1984-12-11

  Carbostyril derivatives of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group and R.sup.2 and R.sup.3 may be the same or different and each is a substituted or unsubstituted lower alkyl group, or R.sup.2 and R.sup.3 may form, together with the adjacent nitrogen atom, a 5- or 6-membered saturated heterocyclic ring which may be substituted or unsubstituted. The derivatives are useful as the active ingredient in cardiotonic compositions.

  通式为##STR1##的Carbostyril衍生物，其中R.sup.1是氢原子、低烷基、低烯基、低炔基或苯基-低烷基，R.sup.2和R.sup.3可能相同或不同，且每个都是取代或未取代的低烷基，或R.sup.2和R.sup.3可能与相邻的氮原子一起形成5或6成员饱和杂环环，该环可能是取代或未取代的。该衍生物可用作强心剂组合物中的活性成分。
• TOMINAGA, MITIAKI;YANAGI, NAGAO;OGAVA, XIDEHNORI;NAKAGAVA, KADZUYUKI
  作者：TOMINAGA, MITIAKI、YANAGI, NAGAO、OGAVA, XIDEHNORI、NAKAGAVA, KADZUYUKI

  DOI：——

  日期：——
• TOMINAGA, MICHIAKI;YO, EIYU;OGAWA, HIDENORI;YAMASHITA, SHUJI;YABUUCHI, YO+, CHEM. AND PHARM. BULL., 1986, 34, N 2, 682-693
  作者：TOMINAGA, MICHIAKI、YO, EIYU、OGAWA, HIDENORI、YAMASHITA, SHUJI、YABUUCHI, YO+

  DOI：——

  日期：——