silver trifluoromethanesulfonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: silver trifluoromethanesulfonate
• 化学式: Ag*CF₃O₃S
• 分子量: 256.939
• InChiKey: WCGIGOVLOFXAMG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.05
• 重原子数：
  9.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.2
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1,3-bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene)dichloro(5-nitro-2-isopropoxyphenylmethylene)ruthenium 、 silver trifluoromethanesulfonate 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以76%的产率得到[Ru(CF₃SO₃)2(IMesH₂)(=CH-2-{2-PrO}5-NO₂C₆H₃)]
  参考文献：
  名称：

  用于离子液体中双相开环易位聚合的离子型格鲁布斯-霍维达络合物：获得低金属含量的聚合物的途径

  摘要：

  新型离子复分解催化剂[Ru（1-CH 3‐4 -CO 2 Py +）2（IMesH 2）（CH-2-{2-PrO}-5‐NO 2 C 6 H 3）] [OTf − ] 2（3 b ; IMesH 2 = 1,3- dimesitylimidazolin -2- ylnene ，Py =吡啶）。3 b和Grubbs-Hoveyda催化剂[Ru（1-CH 3-4 -CO 2 Py +）2（IMesH 2）（CH-2-{2-PrO} C 6 H 4）] [OTf − ] 2（3 a）和[RuCl（1-CH 3 -4-CO 2 Py +）（IMesH 2）（CH-2-{2-PrO} C 6 H 4）] [OTf - ]（5 a）被使用对于开环复分解聚合（ROMP）均相和双相液体-液体的条件下，通过使用离子液体1-丁基-2,3-二甲基咪唑四氟硼酸盐（[BDMIM反应+ ] [BF 4 -和甲苯

  DOI：

  10.1002/cctc.201300751
• 作为试剂：
  描述：

  1-羟基异喹啉 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium phosphate monohydrate 、 silver trifluoromethanesulfonate 、 碘 、 potassium acetate 、 palladium diacetate 、 caesium carbonate 、 溶剂黄146 、 potassium hydroxide 、 sodium hydroxide 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 水 、 二甲基亚砜 、 N,N-二甲基甲酰胺 、 正丁醇 为溶剂， 反应 41.33h， 生成 2-(5-fluoro-3-(1-oxo-2-(4,4,4-trifluorobutyl)-1,2-dihydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid
  参考文献：
  名称：

  Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

  摘要：

  Previously we reported the discovery of CRA-898 (1), a diazine indole acetic acid containing CRTH2 antagonist. This compound had good in vitro and in vivo potency, low rates of metabolism, moderate permeability, and good oral bioavailability in rodents. However, it showed low oral exposure in nonrodent safety species (dogs and monkeys). In the current paper, we wish to report our efforts to understand and improve the poor PK in nonrodents and development of a new isoquinolinone subseries that led to identification of a new development candidate, CRA-680 (44). This compound was efficacious in both a house dust mouse model of allergic lung inflammation (40 mg/kg qd) as well as a guinea pig allergen challenge model of lung inflammation (20 mg/kg bid).

  DOI：

  10.1021/jm401509e

文献信息

• Varying the extended packing of silver(I) ladder-like coordination polymers by modifying the organic group of various organosulfonate anions
  作者：Eric W. Reinheimer、Irfan Hodzic、Nigam P. Rath、Ryan H. Groeneman

  DOI：10.1016/j.poly.2015.06.008

  日期：2015.9

  The ability to reliably produce one-dimensional ladder-like coordination polymers that display different crystal packing has been realized. These ladder polymers are produced by incorporating 4,4'-azopyridine (4,4-Azo) molecules as the bridging ligand that act as the stiles or rods for the ladder. The rungs are based upon silver dimers that interact by means of argentophilic forces which were formed with the assistance of the sulfonate anion. Due to the selection of various organosulfonate anions, namely p-toluenesulfonate, trifluoromethanesulfonate, and methanesulfonate, the ability to vary the R-group serves as an easy component to fine tune the overall packing of the polymeric material. The various polymeric structures and their packing will be discussed with special attention to silver-silver distances not only within the ladder but also between nearest neighbor chains. In addition, the change in occupancy of the bridging 4,4-Azo as a function of temperature will be address as this is indicative of pedal motion within the crystal lattice. Lastly, hydrogen bonding patterns in each will also be discussed as a means to produce multi-dimensional frameworks beyond the ladder-like chain. (C) 2015 Elsevier Ltd. All rights reserved.