β-galactopyranosyl-(1->4)-β-D-mannopyranose | 140461-59-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-galactopyranosyl-(1->4)-β-D-mannopyranose
• 英文别名: β-D-galactopyranosyl-(1->4)-β-D-mannopyranose；Epilaktose；O⁴-β-D-Galactopyranosyl-β-D-mannopyranose；beta-Epilactose；(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
• CAS: 140461-59-2
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: GUBGYTABKSRVRQ-GAXRGOLKSA-N

物化性质

• 熔点：
  195-196 °C
• 沸点：
  667.9±55.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  1',2',3',6',2,3,4,6-octa-O-acetyl-β-D-lactose 在 氢溴酸 、 sodium carbonate 、 copper(II) sulfate 、 溶剂黄146 、 间氯过氧苯甲酸 、 锌 作用下， 以 甲醇 、 乙醚 、 水 为溶剂， 反应 4.0h， 生成 β-galactopyranosyl-(1->4)-β-D-mannopyranose
  参考文献：
  名称：

  Synthesis of the phosphodisaccharide repeat of antigenic lipophosphoglycan of Leishmania donovani parasite

  摘要：

  Synthesis of the immunologically important and structurally unusual phosphodisaccharide repeat unit (Galp1,4 beta-Manp-1 alpha-phosphate) of the lipophosphoglycan cell surface GPI molecule of the protozoan parasite Leishmania donovani has been carried out using lactose as the starting material. The synthesis provides a short and stereoselective route for the preparation of this phosphosaccharide in a preparative scale. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00231-2

文献信息

• Synthesis of the phosphodisaccharide repeat of antigenic lipophosphoglycan of Leishmania donovani parasite
  作者：Mani Upreti、Ram A. Vishwakarma

  DOI：10.1016/s0040-4039(99)00231-2

  日期：1999.3

  Synthesis of the immunologically important and structurally unusual phosphodisaccharide repeat unit (Galp1,4 beta-Manp-1 alpha-phosphate) of the lipophosphoglycan cell surface GPI molecule of the protozoan parasite Leishmania donovani has been carried out using lactose as the starting material. The synthesis provides a short and stereoselective route for the preparation of this phosphosaccharide in a preparative scale. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.