4-[4-(4-Fluoro-phenyl)-3-(3-methyl-pyridin-4-yl)-4-oxo-butyryl]-piperidine-1-carboxylic acid benzyl ester | 861804-84-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[4-(4-Fluoro-phenyl)-3-(3-methyl-pyridin-4-yl)-4-oxo-butyryl]-piperidine-1-carboxylic acid benzyl ester
• CAS: 861804-84-4
• 化学式: C₂₉H₂₉FN₂O₄
• 分子量: 488.559
• InChiKey: HWOUHADLEXTHQL-UHFFFAOYSA-N

物化性质

• 沸点：
  659.6±55.0 °C(predicted)
• 密度：
  1.237±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  36.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  76.57
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-[4-(4-Fluoro-phenyl)-3-(3-methyl-pyridin-4-yl)-4-oxo-butyryl]-piperidine-1-carboxylic acid benzyl ester 在 palladium on activated charcoal 乙酸铵 、 氢气 、 溶剂黄146 作用下， 生成
  参考文献：
  名称：

  Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents

  摘要：

  Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in. in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in Vivo activities. The most potent analogs are the-5-(N-methyl, N-ethyl, and N-methylazetidine methyl) piperidyl derivatives 12, 23, and 34. These compounds have a broad spectrum of activity. Based on the in vivo efficacy and cost of synthesis, the N-ethyl analog 23 was chosen as a novel anticoccidial agent for a field trial. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.060
• 作为产物：
  描述：

  3,4-二甲基吡啶 在 sodium hydride 、 二甲基亚砜 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成 4-[4-(4-Fluoro-phenyl)-3-(3-methyl-pyridin-4-yl)-4-oxo-butyryl]-piperidine-1-carboxylic acid benzyl ester
  参考文献：
  名称：

  Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents

  摘要：

  Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in. in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in Vivo activities. The most potent analogs are the-5-(N-methyl, N-ethyl, and N-methylazetidine methyl) piperidyl derivatives 12, 23, and 34. These compounds have a broad spectrum of activity. Based on the in vivo efficacy and cost of synthesis, the N-ethyl analog 23 was chosen as a novel anticoccidial agent for a field trial. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.060