benzyl 2-N-acetyl-3,6-di-O-benzyl-2-deoxy-5-O-methyl-α-D-mannofuranoside | 119870-40-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: benzyl 2-N-acetyl-3,6-di-O-benzyl-2-deoxy-5-O-methyl-α-D-mannofuranoside
• 英文别名: N-[(2S,3S,4R,5S)-5-[(1R)-1-methoxy-2-phenylmethoxyethyl]-2,4-bis(phenylmethoxy)oxolan-3-yl]acetamide
• CAS: 119870-40-5
• 化学式: C₃₀H₃₅NO₆
• 分子量: 505.611
• InChiKey: BFEFYEJEFFPHHP-JPGUHONBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  37.0
• 可旋转键数：
  13.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  75.25
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  benzyl 2-N-acetyl-3,6-di-O-benzyl-2-deoxy-5-O-methyl-α-D-mannofuranoside 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以90%的产率得到2-N-acetyl-2-deoxy-5-O-methyl-D-mannofuranoside
  参考文献：
  名称：

  Chemoenzymatic synthesis of C8-modified sialic acids and related α2–3- and α2–6-linked sialosides

  摘要：

  Naturally occurring 8-O-methylated sialic acids, including 8-O-methyl-N-acetylneuraminic acid and 8-O-methyl-N-glycolylneuraminic acid, along with 8-O-methyl-2-keto-3-deoxy-D-glycero-D-galactononulosonic acid (Kdn8Me) and 8-deoxy-Kdn were synthesized from corresponding 5-O-modified six-carbon monosaccharides and pyruvate using a sialic acid aldolase cloned from Pasteurella multocida strain P-1059 ( PmNanA). In addition, alpha 2-3- and alpha 2-6-linked sialyltrisaccharides containing Neu5Ac8Me and Kdn8Deoxy were also synthesized using a one-pot multienzyme approach. The strategy reported here provides an efficient approach to produce glycans containing various C8-modified sialic acids for biological evaluations. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.083
• 作为产物：
  描述：

  溴甲苯 在 吡啶 、 sodium azide 、 sodium methylate 、 sodium hydride 、 二正丁基氧化锡 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 、 mineral oil 为溶剂， 反应 30.83h， 生成 benzyl 2-N-acetyl-3,6-di-O-benzyl-2-deoxy-5-O-methyl-α-D-mannofuranoside
  参考文献：
  名称：

  Chemoenzymatic synthesis of C8-modified sialic acids and related α2–3- and α2–6-linked sialosides

  摘要：

  Naturally occurring 8-O-methylated sialic acids, including 8-O-methyl-N-acetylneuraminic acid and 8-O-methyl-N-glycolylneuraminic acid, along with 8-O-methyl-2-keto-3-deoxy-D-glycero-D-galactononulosonic acid (Kdn8Me) and 8-deoxy-Kdn were synthesized from corresponding 5-O-modified six-carbon monosaccharides and pyruvate using a sialic acid aldolase cloned from Pasteurella multocida strain P-1059 ( PmNanA). In addition, alpha 2-3- and alpha 2-6-linked sialyltrisaccharides containing Neu5Ac8Me and Kdn8Deoxy were also synthesized using a one-pot multienzyme approach. The strategy reported here provides an efficient approach to produce glycans containing various C8-modified sialic acids for biological evaluations. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.083

文献信息

• AUGE, CLAUDINE;DAVID, SERGE;GAUTHERON, CHRISTINE;MALLERON, ANNIE;CAVAYE, +, NEW J. CHEM., 12,(1988) N 8-9, C. 733-744
  作者：AUGE, CLAUDINE、DAVID, SERGE、GAUTHERON, CHRISTINE、MALLERON, ANNIE、CAVAYE, +

  DOI：——

  日期：——