2-羟基-3-甲基蒽醌 | 17241-40-6

• 物质功能分类: 天然产物 - 蒽醌
• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 2-羟基-3-甲基蒽醌
• 英文名称: 3-hydroxy-2-methylanthraquinone
• 英文别名: 2-hydroxy-3-methylanthraquinone；2-hydroxy-3-methylanthracene-9,10-dione
• CAS: 17241-40-6
• 化学式: C₁₅H₁₀O₃
• 分子量: 238.243
• InChiKey: RNJHIYAJJKOFIO-UHFFFAOYSA-N

物化性质

• 熔点：
  299 °C
• 沸点：
  439.7±34.0 °C(Predicted)
• 密度：
  1.371±0.06 g/cm3(Predicted)
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2914690090
• 储存条件：
  存储条件：2-8℃，干燥，密闭。

制备方法与用途

从白花蛇耳草的水提取物中分离得到的2-羟基-3-甲氧基蒽醌（化合物1）对蛋白酪氨酸激酶v-src和pp60src具有抑制作用，并能诱导HepG2癌细胞发生凋亡。

反应信息

• 作为反应物：
  描述：

  2-羟基-3-甲基蒽醌 在 sodium sulfide 、 硫酸 、 potassium nitrate 作用下， 生成 1-amino-2-hydroxy-3-methyl-anthraquinone
  参考文献：
  名称：

  Mitter; Pal, Journal of the Indian Chemical Society, 1930, vol. 7, p. 259,261

  摘要：

  DOI：
• 作为产物：
  描述：

  2-chloro-3-methyl-anthraquinone 在 氢溴酸 作用下， 生成 2-羟基-3-甲基蒽醌
  参考文献：
  名称：

  Keimatsu; Hirano, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1929, vol. 49, p. 20

  摘要：

  DOI：

文献信息

• Polymer scale deposition preventive agent
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0760378A1

  公开（公告）日：1997-03-05

  A polymer scale deposition preventive agent comprising (a) an aromatic compound having at least eight conjugated π bonds and having a molecular weight of 1,000 or more, and (b) a polyalkylene oxide having a weight-average molecular weight of 2,000 or more, wherein the weight ratio of the component (a) to the component (b) is 100/500 to 100/1, can prevent surely the deposition of polymer scale even in a polymerization system containing a monomer, such as styrene, acrylic acid esters or acrylonitrile, which has a high solvency for a coating film consisting of the conventional polymer scale deposition preventive agent.

  一种聚合物鳞片沉积防止剂，包括(a)至少有八个共轭π键且分子量大于或等于 1,000 的芳香族化合物，以及(b)重量平均分子量大于或等于 2,000 的聚环氧烷，其中组分(a)与组分(b)的重量比为 100/500 至 100/1、即使在含有单体（如苯乙烯、丙烯酸酯或丙烯腈）的聚合体系中，也能有效防止聚合物鳞片的沉积，该单体对由传统聚合物鳞片沉积防止剂组成的涂膜具有很高的溶解度。
• Vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0805168A1

  公开（公告）日：1997-11-05

  In a process for producing vinyl chloride polymers including polymerization of vinyl chloride or a monomer mixture containing it in an aqueous medium using a polymerization initiator, the polymerization is carried out in the presence of a chelating agent. The chelating agent is capable of chelating iron (II) and iron (III). This process makes it possible to prevent polymer scales from adhering to, e.g. baffle surfaces facing inner walls of the polymerization vessel, which has been hitherto difficult to do so, and less cause initial discoloration of polymer products to improve quality. It is more effective to use a polymerization vessel previously provided with coating films of a polymer scale preventive agent on the inner walls of the polymerization vessel and the other portions with which monomers come into contact in the course of polymerization.

  在生产氯乙烯聚合物的工艺中，包括使用聚合引发剂在水介质中聚合氯乙烯或含有氯乙烯的单体混合物，聚合是在有螯合剂存在的情况下进行的。螯合剂能够螯合铁（II）和铁（III）。这种工艺可以防止聚合物鳞片附着在聚合容器内壁的挡板等表面上（迄今为止很难做到这一点），减少聚合物产品的初始变色，从而提高质量。在聚合容器内壁和聚合过程中单体与之接触的其他部分上涂覆一层聚合物防垢剂的聚合容器更为有效。
• Polymerization process characterized by a two layer coating against scale formation deposited using a steam carrier
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0934955A1

  公开（公告）日：1999-08-11

  An improved process for producing a polymer by polymerizing a monomer having an ethylenic double bond in a polymerization vessel having a polymer scale preventive coating film on its inner wall surfaces, etc. is provided. The coating film is formed by coating a first coating liquid containing a compound selected from the group consisting of an aromatic compound having 5 or more conjugated π bonds and a heterocyclic compound having 5 or more conjugated π bonds, and then coating a second coating liquid on the first layer. The first and second coating liquids are applied by means of steam as a carrier. The second layer has a surface having a contact angle to water of less than 60° after its surface has been brought into contact with a solution of mixture of water and a vinyl chloride monomer in a weight ratio of 1:1, at 50°C for 1 hour. This process can shorten the time for forming the coating film to improve productivity, can improve the effect of preventing adhesion of polymer scale, can make colored particles less mix into polymer products obtained by this process, can lessen fish eyes and initial discoloring of formed products and can improve the quality of polymeric products and their formed or molded products.

  本发明提供了一种通过在聚合容器中聚合具有乙烯双键的单体来生产聚合物的改进工艺，该聚合容器的内壁表面等处具有聚合物防垢涂膜。该涂膜是通过涂覆第一涂覆液形成的，第一涂覆液含有选自具有 5 个或更多共轭 π 键的芳香族化合物和具有 5 个或更多共轭 π 键的杂环化合物的一组化合物，然后在第一层上涂覆第二涂覆液。第一种和第二种涂覆液通过蒸汽作为载体进行涂覆。第二层表面与水和氯乙烯单体重量比为 1:1 的混合物溶液在 50°C 下接触 1 小时后，其表面与水的接触角小于 60°。这种工艺可以缩短涂膜的形成时间，从而提高生产率；可以提高防止聚合物鳞片附着的效果；可以使有色颗粒较少地混入通过这种工艺获得的聚合物产品中；可以减少成型产品的鱼眼和初期褪色现象；可以提高聚合物产品及其成型或模塑产品的质量。
• Rust prevention
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0957145A2

  公开（公告）日：1999-11-17

  A rust preventive composition including (a) a silicic acid compound and (b) an aromatic amine-based condensation product is provided, which is effective in preventing a Zn-based metallic coating from rusting. Rusting is prevented by forming a coating film containing the components (a) and (b) on the surfaces of the Zn-based metallic coating formed on a base such as a metal plate. The resulting coating film exhibits an excellent corrosion resistance, gives no fear of a health problem such as carcinogenesis and provides a desirable black or blackish appearance to a metal surface. In an embodiment wherein a second coating film containing a silicic acid compound is formed on the first coating film, the corrosion resistance is further improved.

  本发明提供了一种防锈组合物，其中包括(a)硅酸化合物和(b)芳香胺基缩合产物，可有效防止锌基金属涂层生锈。通过在金属板等基底上形成的锌基金属涂层表面上形成一层含有 (a) 和 (b) 组分的涂膜来防止生锈。形成的涂膜具有优异的耐腐蚀性，不会产生致癌等健康问题，并为金属表面提供理想的黑色或微黑色外观。在一个实施方案中，在第一层涂膜上形成了含有硅酸化合物的第二层涂膜，从而进一步提高了耐腐蚀性。
• Process for producing a polymer by polymerization of a monomer having an ethylenic double bond
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP1063242A1

  公开（公告）日：2000-12-27

  A process for producing a polymer by polymerizing in a polymerization vessel a monomer having an ethylenic double bond is provided. In this process, the polymerization vessel has a polymer scale preventive coating film on its inner wall surfaces and other surfaces with which the monomer comes into contact during polymerization. The coating film is formed by coating a first coating liquid containing a compound selected from the group consisting of an aromatic compound having 5 or more conjugated π bonds and a heterocyclic compound having 5 or more conjugated π bonds and a second coating liquid containing at least one hydrophilic compound selected from the group consisting of a water-soluble polymeric compound, an inorganic colloid, an inorganic salt and an acid; the first coating liquid and the second coating liquid being simultaneously coated by means of steam as a carrier. This process can shorten the time for forming coating films of scale preventive agents to improve productivity, can improve the effect of preventing scales, can make colored particles less mix into polymer products obtained by this process, can lessen fish eyes and initial discoloring of formed products and can improve the quality of polymeric products and their formed or molded products.

  提供了一种通过在聚合容器中聚合具有乙烯双键的单体来生产聚合物的工艺。在该工艺中，聚合容器的内壁表面和聚合过程中单体接触的其他表面上有一层聚合物防垢涂膜。涂膜是通过涂覆第一涂覆液和第二涂覆液形成的，第一涂覆液含有一种选自具有 5 个或更多共轭 π 键的芳香族化合物和具有 5 个或更多共轭 π 键的杂环化合物的化合物，第二涂覆液含有至少一种选自水溶性高分子化合物、无机胶体、无机盐和酸的亲水性化合物；第一涂覆液和第二涂覆液通过蒸汽作为载体同时涂覆。这种工艺可以缩短防垢剂形成涂膜的时间以提高生产率，可以提高防垢效果，可以使有色颗粒较少地混入通过该工艺获得的聚合物产品中，可以减少成型产品的鱼眼和初始变色，可以提高聚合物产品及其成型或模塑产品的质量。