阳离子蓝3RL | 12217-43-5

• 物质功能分类: 染料及颜料 - 染料 - 碱性染料
• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 阳离子蓝3RL
• 中文别名: 碱性蓝47；C.I.碱性蓝47；碱性蓝 47；阳离子蓝 3RL
• 英文名称: 1-Amino-4-(4-dimethylaminomethyl-phenylamino)-anthraquinone
• 英文别名: 1-Amino-4-((4-((dimethylamino)methyl)phenyl)amino)anthraquinone；1-amino-4-[4-[(dimethylamino)methyl]anilino]anthracene-9,10-dione
• CAS: 12217-43-5
• 化学式: C₂₃H₂₁N₃O₂
• 分子量: 371.439
• InChiKey: IVFRHOQHKQWEHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  570.0±50.0 °C(Predicted)
• 密度：
  1.308±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  5

制备方法与用途

化学性质
可溶于水。染料在浓硫酸中呈现暗紫色，稀释后色泽不变。在120℃高温下进行染色时，颜色光亮度保持稳定。

用途
阳离子蓝3RL适用于染腈纶和二醋酸纤维，可用于直接印花处理腈纶、二醋酸纤维以及蚕丝织物，并可与其他地色染料结合使用，以氯化亚锡为拔染剂的着色色浆。此外，它也可与阳离子金黄、阳离子红拼染，适用于日晒牢度要求高但色泽不需过于鲜艳的深浓色泽。不过，该染料的染深性较差。

生产方法
采用1,4-二氨基蒽醌和对甲氨基氯苯作为原料，首先将两者进行缩合反应，然后通过叔胺化步骤得到目标产物。之后经过滤、干燥等工序最终获得成品。

反应信息

• 作为反应物：
  描述：

  阳离子蓝3RL 、 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 N-[3-[4-bromo-2-[3-(4-methylpiperazin-1-yl)propanoylamino]phenyl]sulfanylphenyl]-N'-[4-[4-[(dimethylamino)methyl]anilino]-9,10-dioxoanthracen-1-yl]heptanediamide
  参考文献：
  名称：

  Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi

  摘要：

  In order to establish structural elements responsible for inhibition of trypanothione reductase (TR) from Trypanosoma cruzi by 2-aminodiphenylsulfides, a series of dissymmetrical derivatives, corresponding to the replacement of one aromatic moiety by different amines, was synthesized. TR inhibition studies revealed the importance of the aromatic rings and of the amino groups in the side chains for potent inhibition. Quinonic moities were also introduced with the aim of acting as TR redox-cycling substrates. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00180-2

文献信息

• COLORING AGENTS AND METHODS OF USE THEREOF
  申请人：Living Proof, Inc.

  公开号：US20160106648A1

  公开（公告）日：2016-04-21

  Dyes, compositions comprising dyes and methods for using the same are provided.

  染料、包含染料的组合物以及使用这些染料的方法。
• Organic colorants and compositions containing same
  申请人：Ragan Sean Michael

  公开号：US20100119709A1

  公开（公告）日：2010-05-13

  Compositions and methods useful for imparting coloration to various substrates including plastics, paper, wood, fabrics, fibers and textiles. Materials comprising water-soluble colorants including an amidine group and a chromophore moiety are contacted with a substrate, and the substrate permitted to dry to provide substantially water-proof coloration on the substrate. In one embodiment an ink, coating, or dye is an aqueous composition comprising one or more amidines as provided herein, which is contained within a vessel that includes a gas at an effective level of pressure to enable the gas to react with an amidine as herein provided, to provide and maintain the amidine substantially in its protonated form prior to application of the aqueous composition to a desired substrate.

  用于给各种基材（包括塑料、纸张、木材、织物、纤维和纺织品）赋予着色的组合物和方法。包括一种酰胺基团和色团基团的水溶性着色剂材料与基材接触，然后让基材干燥，以在基材上提供基本防水的着色。在一个实施例中，一种墨水、涂层或染料是一种水性组合物，包括本文提供的一种或多种酰胺，该组合物包含在一个容器中，该容器包括一种气体，气体的有效压力水平使气体能够与本文提供的酰胺发生反应，以在将水性组合物应用到所需基材之前，提供并保持酰胺基本上处于其质子化形式。
• Methods for coating surfaces with antimicrobial agents
  申请人：The Board of Regents of the University of Texas System

  公开号：US10589003B2

  公开（公告）日：2020-03-17

  Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.

  本发明公开了用抗菌剂涂覆或浸渍表面的方法，包括用包括抗菌剂和溶剂的组合物接触表面，并通过加热固化表面。还公开了降低需要使用医疗器械的受试者发生或恶化感染风险的方法，包括用抗菌剂涂覆或浸渍医疗器械表面，然后通过加热固化表面，从而降低发生或恶化感染的风险。
• ANTHRAQUINONES AS INHIBITORS OF SULFIDE PRODUCTION FROM SULFATE-REDUCING BACTERIA
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0525073A1

  公开（公告）日：1993-02-03
• MITTEL ZUM F RBEN VON KERATINHALTIGEN FASERN
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：EP1575540A1

  公开（公告）日：2005-09-21