N,N-(氧代二-4,1-亚苯基)二乙酰胺 | 3070-86-8

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N,N-(氧代二-4,1-亚苯基)二乙酰胺
• 中文别名: N,N′-(氧代二-4,1-亚苯基)二乙酰胺
• 英文名称: 4,4'-diacetamidodiphenyl ether
• 英文别名: bis(4-acetylaminophenyl) ether；Bis(p-acetylaminophenyl) ether；N-[4-(4-acetamidophenoxy)phenyl]acetamide
• CAS: 3070-86-8
• 化学式: C₁₆H₁₆N₂O₃
• 分子量: 284.315
• InChiKey: BUGCHAIWUSBYIZ-UHFFFAOYSA-N

物化性质

• 熔点：
  230-231 °C(lit.)
• 沸点：
  554.4±35.0 °C(Predicted)
• 密度：
  1.256±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• 稳定性/保质期：
  如果按照规格正确使用和储存，则不会发生分解，也未有已知危险。

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• WGK Germany：
  3
• 海关编码：
  2924299090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  请将药品存放在密闭、阴凉干燥的地方保存。

反应信息

• 作为反应物：
  描述：

  N,N-(氧代二-4,1-亚苯基)二乙酰胺 在 10% Pd/C 、 水 、 氢气 、 硝酸 、 sodium hydrogensulfite 、 溶剂黄146 、 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 8.0h， 生成 2,2'-diphenyl-5,5'-bisbenzimidazolyl ether
  参考文献：
  名称：

  Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy

  摘要：

  In this study, a new series of bis-benzimidazole derivatives were designed and synthesized. Most of these new compounds showed significant anti-tumor activity in vitro compared to Hoechst 33258. Among them, the most potent compound 8 had the IC50 values of 0.56 mu M for HL60 (Human promyelocytic leukemia cells) tumor cell line and 0.58 mu M for U937 (Human leukemic monocyte lymphoma cells) tumor cell line. Subsequent toxicity study on human peripheral blood mononuclear cells (PBMC) showed that compound 8 exhibited less toxicity than 5-FU. We also found that apoptosis and autophagy were simultaneously induced by compound 8 in HL60 cells, and inhibition of autophagy by 3-MA decreased compound 8-induced apoptosis, indicating that they acted in synergy to exert tumor cell death. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.102
• 作为产物：
  描述：

  4,4-二硝基二苯醚 在 三氯化铁 、 甲烷 、 肼 作用下， 以 1,4-二氧六环 、 氯苯 为溶剂， 反应 2.0h， 生成 N,N-(氧代二-4,1-亚苯基)二乙酰胺
  参考文献：
  名称：

  Synthesis and Structure of Di[methoxy(ethoxy)carbonylamino-1H-benzimidazol-5-yl] Ethers

  摘要：

  开发了一种制备di[methoxy(ethoxy)carbonylamino-1H-benzimidazol-5-yl]醚的方法，该方法通过甲基或乙基氯甲酸酯与氰胺钠反应，然后将所得的甲基或乙基氰基氨基甲酸酯与4-(3,4-二氨基苯氧基)-1,2-苯二胺在酸性溶液中反应。

  DOI：

  10.1007/s11176-005-0459-8

文献信息

• 3,3′-二硝基-4,4′-二乙酰氨基二苯醚的制备方法
  申请人：浙江闰土股份有限公司

  公开号：CN113429309A

  公开（公告）日：2021-09-24

  本发明提供一种3,3’‑二硝基‑4,4’‑二乙酰氨基二苯醚的制备方法，其包括以下步骤：酰化步骤：在4,4’‑二氨基二苯醚中加入酰化剂，进行酰化反应，得到酰化产物；硝化步骤：对所述酰化产物进行降温后，加入硝酸进行硝化反应，得到硝化产物。本发明原料4,4’‑二氨基二苯醚直接在酰化剂体系中进行酰化和硝化两个步骤，中间不需取出酰化物，步骤简易，损耗低，纯度高，收率高。
• Solvent resistant photosensitive compositions
  申请人：——

  公开号：US20030064316A1

  公开（公告）日：2003-04-03

  Photoresist compositions and methods are provided for preparing photoresist films that are stable and impermeable to a broad range of organic solvents. Photoresist films provided herein may be photopatterned by selectively applying light, and may be stripped from a surface using unreactive agents. Photopatterned films may be used, for example, to selectively direct organic reagents to a solid support for the purpose of performing regionally selective solid-phase chemical synthesis with micron-scale resolution.

  提供了用于制备稳定且不透水的光阻膜的光阻组合物和方法，可防止广泛范围的有机溶剂渗透。本文提供的光阻膜可以通过选择性施加光线进行光图案化，并可以使用不活性试剂从表面剥离。例如，可以使用光图案化的膜有选择地将有机试剂定向到固体支持体上，以进行具有微米级分辨率的区域选择性固相化学合成。
• POLYAMIDE ACID RESIN COMPOSITION, POLYIMIDE FILM USING SAME, AND METHOD FOR PRODUCING SAID POLYIMIDE FILM
  申请人：Toray Industries, Inc.

  公开号：EP2881417A1

  公开（公告）日：2015-06-10

  An object is to provide a polyamic acid resin composition that can form a varnish with a low viscosity and serves to produce, through curing, coat film with good mechanical characteristics. Another object is to provide a polyamic acid resin composition in which the acid anhydride terminal group is low in reactivity with diamine and which can give a varnish that does not suffer significant precipitation of diamine. These objects can be met by a polyamic acid resin composition that contains: (a) polyamic acid and (b) a compound as represented by chemical formula (1). (In Chemical formula (1), Z is a di- or higher-valent organic group containing 2 or more carbon atoms, V is a structure as represented by chemical formula (2), and k is an integer of 2 or more.) (In In Chemical formula (2), δ represents oxygen or sulfur atom and W represents an electron-withdrawing group, and R11 and R12 represent independently a hydrogen atom or a hydrocarbon group containing 1 to 10 carbon atoms.

  一个目的是提供一种聚酰胺酸树脂组合物，它能形成一种低粘度清漆，并能通过 固化产生具有良好机械特性的涂膜。另一个目的是提供一种聚氨基甲酸酯树脂组合物，其中的酸酐端基与二胺的反应活性较低，并能产生一种二胺不会明显析出的清漆。含有以下成分的聚酰胺树脂组合物可以达到上述目的：(a) 聚酰胺和 (b) 化学式（1）所表示的化合物。(在化学式（1）中，Z 是含有 2 个或 2 个以上碳原子的二价或高价有机基团，V 是化学式（2）所代表的结构，k 是 2 个或 2 个以上的整数）。(在化学式（2）中，δ代表氧原子或硫原子，W代表抽电子基团，R11 和 R12 独立地代表氢原子或含有 1 至 10 个碳原子的烃基。
• Abuzar, Syed; Sharma, Satyavan; Gupta, Suman, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 12, p. 1274 - 1278
  作者：Abuzar, Syed、Sharma, Satyavan、Gupta, Suman、Misra, Anuradha、Katiyar, J. C.

  DOI：——

  日期：——
• Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents
  作者：Xiu-Jun Wang、Ming-Li Yang、Lan-Ping Zhang、Tong Yao、Cheng Chen、Lian-Gang Mao、Yin Wang、Jie Wu

  DOI：10.1016/j.cclet.2014.01.019

  日期：2014.4

  A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 mu mol/L (mononuclear tumor cell line (U937)) and 5.58 mu mol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. (C) 2014 Ming-Li Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.