4,6-二氯-1,3-苯二胺 | 20248-64-0

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,6-二氯-1,3-苯二胺
• 中文别名: 4,6-二氯苯-1,3-二胺；(5-氨基-2,4-二氯-苯基)胺
• 英文名称: 4,6-dichloro-1,3-benzenediamine
• 英文别名: 4,6-dichloro-1,3-phenylenediamine；4,6-dichlorobenzene-1,3-diamine；1,3-Dichloro-4,6-diaminobenzene；1,3-diamino-4,6-dichlorobenzene；4,6-dichloro-m-phenylenediamine；4,6-Dichlor-m-phenylendiamin
• CAS: 20248-64-0
• 化学式: C₆H₆Cl₂N₂
• mdl: MFCD00456308
• 分子量: 177.033
• InChiKey: SSXPQLXWKPOYLJ-UHFFFAOYSA-N

物化性质

• 熔点：
  138-139 °C
• 沸点：
  313.2±37.0 °C(Predicted)
• 密度：
  1.501±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2921519090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  存储条件：2-8℃，干燥且密封保存。

反应信息

• 作为反应物：
  描述：

  4,6-二氯-1,3-苯二胺 生成 1,2,4,5-四氯苯
  参考文献：
  名称：

  Functional school refusal subtypes: Anxiety, avoidance, and malingering

  摘要：

  Chronic school refusal has traditionally been classified under broad categories such as school phobia and truancy. However, the need for improved recognition and treatment of school refusal has heightened efforts to identify subtypes of school refusal behavior. Recent efforts have focused on functional subtypes of school refusal. This article purposes to extend recent efforts by showing that the three basic subtypes of anxiety, avoidance, and malingering are not only functional, bur consistent with refusal characteristics, empirical evidence from factor analysis and clinical diagnosis over the past decade, and treatment approaches. Such extension is intended to aid practitioners in further understanding and using functional subtypes. (C) 2000 John Wiley & Sons, Inc.

  DOI：

  10.1002/(sici)1520-6807(200003)37:2<183::aid-pits9>3.0.co;2-5
• 作为产物：
  描述：

  N-(3-乙酰氨基苯基)乙酰胺 在 sodium hypochlorite 、 potassium dicarbonate 、 溶剂黄146 作用下， 生成 4,6-二氯-1,3-苯二胺
  参考文献：
  名称：

  Functional school refusal subtypes: Anxiety, avoidance, and malingering

  摘要：

  Chronic school refusal has traditionally been classified under broad categories such as school phobia and truancy. However, the need for improved recognition and treatment of school refusal has heightened efforts to identify subtypes of school refusal behavior. Recent efforts have focused on functional subtypes of school refusal. This article purposes to extend recent efforts by showing that the three basic subtypes of anxiety, avoidance, and malingering are not only functional, bur consistent with refusal characteristics, empirical evidence from factor analysis and clinical diagnosis over the past decade, and treatment approaches. Such extension is intended to aid practitioners in further understanding and using functional subtypes. (C) 2000 John Wiley & Sons, Inc.

  DOI：

  10.1002/(sici)1520-6807(200003)37:2<183::aid-pits9>3.0.co;2-5

文献信息

• Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20150231142A1

  公开（公告）日：2015-08-20

  The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

  本发明涉及含有上皮钠通道活性抑制剂与至少一种ABC转运蛋白调节剂化合物（A式、B式、C式或D式）的药物组合物。该发明还涉及这些药物配方，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
• COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
  申请人：Van Goor Fredrick F.

  公开号：US20110098311A1

  公开（公告）日：2011-04-28

  The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

  本发明涉及包含上皮钠通道活性抑制剂与至少一种ABC转运蛋白调节剂化合物（A式、B式、C式或D式）的药物组合物。该发明还涉及这些药物配方，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
• N-Phenyl-substituted N-heterocyclic compounds, their preparation and use
  申请人：Ciba-Geigy Corporation

  公开号：US04208202A1

  公开（公告）日：1980-06-17

  The present invention relates to novel active compounds having a plant growth-inhibiting and herbicidal action and their preparation and to agents containing these active ingredients, and their use. The novel active compounds are saturated and unsaturated 4-membered to 7-membered ring nitrogen heterocyclic compounds which are substituted on the nitrogen atom by a phenyl radical which itself carries a trifluoromethanesulphonamido group --NH--SO.sub.2 --CF.sub.3 as a substituent. The phenyl radical can also carry other substituents and the heterocyclic structure can also be substituted. Oxo derivatives of the heterocyclic compound, in which the oxo group is preferably adjacent to the nitrogen atom, form a preferred sub-group of compounds.

  本发明涉及具有植物生长抑制和除草作用的新型活性化合物及其制备方法，以及含有这些活性成分的制剂及其用途。这些新型活性化合物是饱和和不饱和的4-7元环氮杂环化合物，氮原子上取代有一个苯基基团，该基团本身携带三氟甲磺胺基--NH--SO.sub.2 --CF.sub.3 作为取代基。苯基基团也可以携带其他取代基，杂环结构也可以被取代。在杂环化合物的氧代衍生物中，氧代基偏好邻近氮原子，形成化合物的一个优选亚组。
• Novel N-phenyl-substituted N-heterocyclic compounds, their preparation
  申请人：Ciba-Geigy Corporation

  公开号：US04394156A1

  公开（公告）日：1983-07-19

  The present invention relates to novel active compounds having a plant growth-inhibiting and herbicidal action and their preparation and to agents containing these active ingredients, and their use. The novel active compounds are saturated and unsaturated 4-membered to 7-membered ring nitrogen heterocyclic compounds which are substituted on the nitrogen atom by a phenyl radical which itself carries a trifluoromethanesulphonamido group -NH-SO.sub.2 -CF.sub.3 as a substituent. The phenyl radical can also carry other substituents and the heterocyclic structure can also be substituted. Oxo derivatives of the heterocyclic compound, in which the oxo group is preferably adjacent to the nitrogen atom, form a preferred sub-group of compounds.

  本发明涉及具有植物生长抑制和除草作用的新型活性化合物及其制备方法，以及含有这些活性成分的制剂及其用途。这些新型活性化合物是饱和和不饱和的4-7元环氮杂环化合物，氮原子上取代有一个苯基基团，该苯基基团本身携带三氟甲磺酰胺基-NH-SO.sub.2-CF.sub.3作为取代基。苯基基团也可以携带其他取代基，杂环结构也可以被取代。在这些杂环化合物的氧代衍生物中，氧代基最好是邻接于氮原子的，形成了化合物的一个优选亚组。
• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
  申请人：Sheth Urvi

  公开号：US20120309758A1

  公开（公告）日：2012-12-06

  The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

  本发明涉及调节ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节蛋白，以及相关的组合物和方法。本发明还涉及使用这些调节剂治疗ABC转运蛋白介导的疾病的方法。