Mn(citrate) | 5968-88-7

• 物质功能分类: 有机原料 - 有机金属盐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Mn(citrate)
• 英文别名: manganese(III) acetate；1,2,3-Propanetricarboxylic acid, 2-hydroxy-, manganese(3+) salt (1:1)；2-hydroxypropane-1,2,3-tricarboxylate;manganese(3+)
• CAS: 5968-88-7
• 化学式: C₆H₅O₇*Mn
• 分子量: 244.04
• InChiKey: XMLHTAFIAXPIDG-UHFFFAOYSA-K

物化性质

• 颜色/状态：
  White powder
• 溶解度：
  Soluble in water in presence of sodium citrate

计算性质

• 辛醇/水分配系数(LogP)：
  -5.26
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  141
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

代谢

锰主要通过摄入被吸收，但也可以通过吸入。它在血浆中与α-2-巨球蛋白、白蛋白或转铁蛋白结合，并分布到大脑和所有其他哺乳动物组织，尽管它倾向于在肝脏、胰腺和肾脏中积累更多。锰能够存在于多种氧化状态，并且据信在体内会发生氧化状态的变化。锰的氧化状态可以影响组织的毒物动力学行为，甚至可能影响毒性。锰主要通过粪便排出。(L228)

Manganese is absorbed mainly via ingestion, but can also be inhaled. It binds to alpha-2-macroglobulin, albumin, or transferrin in the plasma and is distributed to the brain and all other mammalian tissues, though it tends to accumulate more in the liver, pancreas, and kidney. Manganese is capable of existing in a number of oxidation states and is believed to undergo changes in oxidation state within the body. Manganese oxidation state can influence tissue toxicokinetic behavior, and possibly toxicity. Manganese is excreted primarily in the faeces. (L228)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

锰是一种细胞毒素，可以损害运输系统、酶活性和受体功能。它主要针对中枢神经系统，尤其是基底神经节中的苍白球。人们认为，锰离子Mn(II)增强了各种胞内儿茶酚胺的自动氧化或转换，导致自由基、活性氧种和其他细胞毒素代谢产物的产生增加，同时耗尽细胞的抗氧化防御机制，导致氧化损伤和选择性破坏多巴胺能神经元。除了多巴胺，还认为锰会干扰其他神经递质，如GABA和谷氨酸。为了产生氧化损伤，锰必须首先克服抗氧化酶超氧化物歧化酶。Mn(II)的神经毒性还与其在生理条件下替代Ca(II)的能力有关。它可以通过钙单向转运体进入线粒体并抑制线粒体氧化磷酸化。它还可能抑制Ca(II)的外流，这可能导致线粒体膜完整性的丧失。Mn(II)已被证明能显著抑制线粒体顺乌头酸酶活性，改变氨基酸代谢和细胞铁稳态。(L228)

Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit mitochondrial aconitase activity to a significant level, altering amino acid metabolism and cellular iron homeostasis. (L228)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

锰主要影响神经系统，可能导致行为改变和其他神经系统效应，包括动作可能变得缓慢和笨拙。这些症状足够严重时，被称为

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L228）；吸入（L228）

Oral (L228) ; inhalation (L228)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

锰主要影响神经系统，可能导致行为改变和其他神经系统效应，包括动作可能变得缓慢和笨拙。这些症状足够严重时，被称为

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  Mn(citrate) 、 Ho(citrate) 以 水 为溶剂， 生成 holmium manganite
  参考文献：
  名称：

  Munnoz, A.; Alonso, J. A.; Casais, M. T., Journal of Alloys and Compounds, 2001, vol. 323 - 324, p. 486 - 489

  摘要：

  DOI：
• 作为产物：
  描述：

  manganese (II) nitrate tetrahydrate 、 柠檬酸 在 氨 作用下， 以 水 为溶剂， 反应 336.0h， 生成 Mn(citrate)
  参考文献：
  名称：

  掺Cr螺旋反铁磁体BiMnFe2O6的晶体结构和磁性能

  摘要：

  图形摘要： - 亮点： • 在 BiMnFe{sub 2}O{sub 6} 中用 Cr 代替 Mn 是可能的，采用溶液-凝胶法是可能的。• 对于高达 0.3 的 x 值，获得 BiCr{sub x}Mn{sub 1-x}Fe{sub 2}O{sub 6} 固溶体。• 增加 Cr 含量会降低反铁磁有序的温度。- 摘要：我们报告了 BiMnFe{sub 2}O{sub 6} 结构中 Mn{sup 3+} 取代的 Cr{sup 3+}。BiCr{sub x}Mn{sub 1-x}Fe{sub 2}O{sub 6} 固溶体是通过溶液-凝胶合成技术获得的，x 值高达 0.3。结合使用 X 射线粉末衍射和透射电子显微镜进行的晶体结构研究表明，这些化合物保留了母体 BiMnFe{sub 2}O{sub 6} 结构（对于 x = 0.3，a = 5.02010(6)Å, b = 7.06594(7)Å, c

  DOI：

  10.1016/j.materresbull.2013.04.038

文献信息

• Fertilizer compositions including chelated metal ions
  申请人：Stoller Enterprises, Inc.

  公开号：US05997600A1

  公开（公告）日：1999-12-07

  The present invention is directed to fertilizer additives and compositions, and to methods for their preparation and administration to plants. The fertilizer additives include chelated metal ions of the transition and alkaline earth metals. The chelated metal solutions are prepared by complexing metal cations using an organic acid and an organic amine. The fertilizer additives include a sufficient quantity of amine to maintain the pH above about 7.5 and preferably about 8-11. While the source of the metal ions may be any biologically acceptable metal salt, the metal oxides are preferred. The preferred chelating agents are citric acid and a difunctional amine. The preferred amines are 2-hydroxyethylamine, dimethylaminopropylamine and mixtures thereof. Additive solutions containing such chelated metals are stable at alkaline pH and are used to prepared clear, liquid fertilizer compositions for delivery of trace metals to plants.

  本发明涉及肥料添加剂和组合物，以及其制备和施用于植物的方法。肥料添加剂包括过渡和碱土金属的螯合金属离子。通过使用有机酸和有机胺络合金阳离子来制备螯合金属溶液。肥料添加剂包括足够数量的胺以维持pH值在7.5左右，最好在8-11之间。虽然金属离子的来源可以是任何生物可接受的金属盐，但金属氧化物是首选。首选的螯合剂是柠檬酸和双官能胺。首选的胺是2-羟乙胺，二甲基氨丙胺和其混合物。含有这些螯合金属的添加剂溶液在碱性pH下稳定，并用于制备透明的液态肥料组合物以向植物提供微量金属。
• Crystal structure and magnetic properties of the Cr-doped spiral antiferromagnet BiMnFe2O6
  作者：Dmitry Batuk、Christopher De Dobbelaere、Alexander A. Tsirlin、Artem M. Abakumov、An Hardy、Marlies K. Van Bael、Martha Greenblatt、Joke Hadermann

  DOI：10.1016/j.materresbull.2013.04.038

  日期：2013.9

  substitution of Cr for Mn in BiMnFesub 2}Osub 6} is possible by the solution–gel method. • The BiCrsub x}Mnsub 1−x}Fesub 2}Osub 6} solid solution is obtained for the x values up to 0.3. • Increasing Cr content lowers the temperature of the antiferromagnetic ordering. - Abstract: We report the Crsup 3+} for Mnsup 3+} substitution in the BiMnFesub 2}Osub 6} structure. The BiCrsub x}Mnsub 1−x}Fesub

  图形摘要： - 亮点： • 在 BiMnFesub 2}Osub 6} 中用 Cr 代替 Mn 是可能的，采用溶液-凝胶法是可能的。• 对于高达 0.3 的 x 值，获得 BiCrsub x}Mnsub 1-x}Fesub 2}Osub 6} 固溶体。• 增加 Cr 含量会降低反铁磁有序的温度。- 摘要：我们报告了 BiMnFesub 2}Osub 6} 结构中 Mnsup 3+} 取代的 Crsup 3+}。BiCrsub x}Mnsub 1-x}Fesub 2}Osub 6} 固溶体是通过溶液-凝胶合成技术获得的，x 值高达 0.3。结合使用 X 射线粉末衍射和透射电子显微镜进行的晶体结构研究表明，这些化合物保留了母体 BiMnFesub 2}Osub 6} 结构（对于 x = 0.3，a = 5.02010(6)Å, b = 7.06594(7)Å, c
• Munnoz, A.; Alonso, J. A.; Casais, M. T., Journal of Alloys and Compounds, <hi>2001</hi>, vol. 323 - 324, p. 486 - 489
  作者：Munnoz, A.、Alonso, J. A.、Casais, M. T.、Martinez-Lope, M. J.、Martinez, J. L.、Fernandez, M. T.

  DOI：——

  日期：——