2-(2-氨基苯基)乙基氨基甲酸叔丁酯 | 180147-34-6

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2-氨基苯基)乙基氨基甲酸叔丁酯
• 英文名称: [(2-aminophenyl)ethyl]carbamic acid tert-butyl ester
• 英文别名: [2-(2-aminophenyl)ethyl]carbamic acid tert-butyl ester；[2-(2-Amino-phenyl)-ethyl]-carbamic acid tert-butyl ester；tert-butyl N-[2-(2-aminophenyl)ethyl]carbamate
• CAS: 180147-34-6
• 化学式: C₁₃H₂₀N₂O₂
• 分子量: 236.314
• InChiKey: NRAJUZPLCXKIRP-UHFFFAOYSA-N

物化性质

• 沸点：
  397.0±25.0 °C(Predicted)
• 密度：
  1.077±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: [2-(2-Amino-phenyl)-ethyl]-carbamic acid tert-butyl ester
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: [2-(2-Amino-phenyl)-ethyl]-carbamic acid tert-butyl ester
CAS number: 180147-34-6

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C13H20N2O2
Molecular weight: 236.3

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-(2-氨基苯基)乙基氨基甲酸叔丁酯 在 3 A molecular sieve 、 三乙酰氧基硼氢化钠 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 N-(4S)-[4-amino-5-[2-(2-aminoethyl)phenylamino]-pentyl]-N'-nitroguanidine
  参考文献：
  名称：

  Aromatic Reduced Amide Bond Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase

  摘要：

  Nitric oxide synthase inhibitors could act as important therapies for disorders arising from overstimulation or overexpression of individual nitric oxide synthase (NOS) isoforms. But preservation of physiologically important nitric oxide functions require the use of isoform-selective inhibitors. Recently we reported reduced amide bond pseudodipeptide analogues as potent and selective neuronal nitric oxide synthase (nNOS) inhibitors (Hah, J.-M.; Roman, L. J.; Martasek, P.; Silverman, R. B. J. Med. Chem. 2001, 44, 2667-2670). To increase the lipophilicity a series of aromatic, reduced amide bond analogues (6-25) were designed and synthesized as potential selective nNOS inhibitors. The hypothesized large increase in isoform selectivity of nNOS over inducible NOS was not obtained in this series. However, the high potency with nNOS as well as high selectivity of nNOS over endothelial NOS was retained in some of these compounds (15, 17, 21), as well as good selectivity over inducible NOS. The most potent nNOS inhibitor among these compounds is N-(4S)-{4-amino-5-[2-(2-aminoethyl)phenylamino]-pentyl}-N'-nitroguanidine (17) (K-i = 50 nM), which also shows the highest selectivity over eNOS (greater than 2100-fold) and 70-fold selectivity over iNOS. Further modification of compound 17 should lead to even more potent and selective nNOS inhibitors.

  DOI：

  10.1021/jm0202932
• 作为产物：
  描述：

  2-氨基苯乙腈 在 tin(ll) chloride 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 2.5h， 生成 2-(2-氨基苯基)乙基氨基甲酸叔丁酯
  参考文献：
  名称：

  Aromatic Reduced Amide Bond Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase

  摘要：

  Nitric oxide synthase inhibitors could act as important therapies for disorders arising from overstimulation or overexpression of individual nitric oxide synthase (NOS) isoforms. But preservation of physiologically important nitric oxide functions require the use of isoform-selective inhibitors. Recently we reported reduced amide bond pseudodipeptide analogues as potent and selective neuronal nitric oxide synthase (nNOS) inhibitors (Hah, J.-M.; Roman, L. J.; Martasek, P.; Silverman, R. B. J. Med. Chem. 2001, 44, 2667-2670). To increase the lipophilicity a series of aromatic, reduced amide bond analogues (6-25) were designed and synthesized as potential selective nNOS inhibitors. The hypothesized large increase in isoform selectivity of nNOS over inducible NOS was not obtained in this series. However, the high potency with nNOS as well as high selectivity of nNOS over endothelial NOS was retained in some of these compounds (15, 17, 21), as well as good selectivity over inducible NOS. The most potent nNOS inhibitor among these compounds is N-(4S)-{4-amino-5-[2-(2-aminoethyl)phenylamino]-pentyl}-N'-nitroguanidine (17) (K-i = 50 nM), which also shows the highest selectivity over eNOS (greater than 2100-fold) and 70-fold selectivity over iNOS. Further modification of compound 17 should lead to even more potent and selective nNOS inhibitors.

  DOI：

  10.1021/jm0202932

文献信息

• [EN] NOVEL PYRAZINE AMIDE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS PYRAZINE-AMIDES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2015018754A1

  公开（公告）日：2015-02-12

  The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6 and X- have one of the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

  本发明涉及式1的化合物或其药用盐，其中R1、R2、R3、R5、R6和X-具有规范中指示的含义之一，其用作药物，用于治疗呼吸道疾病或疾病和过敏性疾病，包括至少一种所述化合物或其药用盐的药物组合的制药组合。
• THIENYL [3,2-D] PYRIMIDIN-4-ONE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20140323466A1

  公开（公告）日：2014-10-30

  Disclosed are new thienyl[3,2-d]pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.

  本文披露了新的噻吩基[3,2-d]嘧啶-4-酮化合物，其一般式为(I)，以及其制备方法、药物组合物和药理用途。这些化合物是强效的DPPIV（二肽肽酶IV）抑制剂，可以通过有效抑制DPPIV间接增加体内GLP-1的含量，并在体内诱导一系列生理作用来治疗II型糖尿病。因此，这些化合物可以作为治疗糖尿病的新型有前途的药物进行开发。
• Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools
  作者：Tao Hu、Guoxun Zheng、Dongxiang Xue、Simeng Zhao、Fei Li、Fang Zhou、Fei Zhao、Linshan Xie、Cuiping Tian、Tian Hua、Suwen Zhao、Yueming Xu、Guisheng Zhong、Zhi-Jie Liu、Alexandros Makriyannis、Raymond C. Stevens、Houchao Tao

  DOI：10.1021/acs.jmedchem.1c01088

  日期：2021.9.23

  the development of photoswitchable ligands for the cannabinoid receptor 2 (CB2). Based on the analysis of residue-type clusters surrounding the binding pocket, we conclude that among the three representative atypical arms of the CB2 antagonist, AM10257, the adamantyl arm is the most appropriate for azobenzene remodeling. The optimizing spacer length and attachment position revealed AzoLig 9 with excellent

  偶氮苯嵌入的光开关配体是光药理学研究中广泛使用的化学工具。当前引入偶氮苯的方法主要依赖于典型可偶氮基团的等排置换。然而，非典型支架可能会为光开关重塑提供更多机会，这在化学上占绝大多数。在此，我们研究了用于偶氮苯引入的非典型支架的合理改造，如大麻素受体 2 (CB2) 的光开关配体的开发示例。基于对结合袋周围残基型簇的分析，我们得出结论，在 CB2 拮抗剂 AM10257 的三个代表性非典型臂中，金刚烷基臂最适合偶氮苯重塑。AzoLig 9具有出色的热双稳定性、两种配置之间良好的光药理学可切换性和高亚型选择性。这种结构引导的方法为工具定制的新化学空间的扩展提供了新的动力，以用于日益多样化的光药理学研究及其他领域。
• Selective neuronal nitric oxide synthase inhibitors
  申请人：——

  公开号：US20030119751A1

  公开（公告）日：2003-06-26

  Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase.

  用于选择性抑制神经元一氧化氮合酶的肽类模拟物组合。
• [EN] ETHYLENE DIAMINE MODULATORS OF FATTY ACID AMIDE HYDROLASE<br/>[FR] MODULATEURS D'ÉTHYLÈNE DIAMINE D'UNE AMIDE HYDROLASE D'ACIDE GRAS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011022348A1

  公开（公告）日：2011-02-24

  Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

  描述了Formula (I)中的某些乙烯二胺化合物，这些化合物可作为FAAH抑制剂。这种化合物可用于制备药物组合物，并用于治疗由脂肪酸酰胺水解酶(FAAH)活性介导的疾病状态、紊乱和情况，如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢紊乱和运动障碍(例如多发性硬化)。还公开了合成这种化合物的方法。