D-甘露酸 | 22076-54-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: D-甘露酸
• 英文名称: D-mannaric acid
• 英文别名: D-manno-2,3,4,5-Tetrahydroxy-adipinsaeure；D-Mannarsaeure；d-Mannozuckersaeure；mannaric acid；Mannarsaeure；(2S,3S,4S,5S)-2,3,4,5-tetrahydroxyhexanedioic acid
• CAS: 22076-54-6
• 化学式: C₆H₁₀O₈
• 分子量: 210.141
• InChiKey: DSLZVSRJTYRBFB-LDHWTSMMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  D-甘露酸 在 聚合甲醛 、 硫酸 作用下， 生成 O²,O³;O⁴,O⁵-dimethanediyl-mannaric acid
  参考文献：
  名称：

  23.山梨糖醇和甘露糖醇的二苯甲酸酯及其亚甲基衍生物

  摘要：

  DOI：

  10.1039/jr9440000058
• 作为产物：
  描述：

  甘露醇 在 硝酸 作用下， 生成 D-甘露酸
  参考文献：
  名称：

  XXXIV.—硝酸将甘露醇氧化。d。甘露糖精酸

  摘要：

  DOI：

  10.1039/ct8915900306

文献信息

• Modifications in the nitric acid oxidation of d-mannose: X-ray crystal structure of N,N′-dimethyl d-mannaramide
  作者：Chrissie A. Carpenter、Kenneth I. Hardcastle、Donald E. Kiely

  DOI：10.1016/j.carres.2013.05.004

  日期：2013.7

  Nitric acid oxidation of D-mannose was carried out under an oxygen atmosphere using a computer controlled reactor. The process represents a catalytic oxidation of D-mannose with oxygen as the terminal oxidant. The crude oxidation product was esterified with methanolic HCl and the esterified product directly converted to crystalline N,N'-dimethyl-D-mannaramide with methylamine. Treatment of the diamide

  使用计算机控制的反应器在氧气气氛下进行D-甘露糖的硝酸氧化。该方法代表用氧作为末端氧化剂对D-甘露糖的催化氧化。用甲醇的HCl酯化粗氧化产物，然后用甲胺将酯化产物直接转化为结晶的N，N′-二甲基-D-马那酰胺。在氢氧化钠水溶液中处理二酰胺，得到固体D-甘露酸钠。N，N′-二甲基-D-马那酰胺的X射线晶体结构被确定为立体规则聚（亚烷基-D-马那酰胺）的重复D-马那酰胺单元的模型。制备了D-甘露酸钠二酯作为酯化的D-月桂酸的前体，用作反应性二酸单体以制备聚-D-月桂酰胺。
• Method of oxidization using nitric acid
  申请人：Kiely Donald E.

  公开号：US20080033205A1

  公开（公告）日：2008-02-07

  A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20° C. to 45° C. in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation/evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.

  采用氧气和硝酸作为共同氧化剂的控制硝酸工艺用于将有机化合物氧化成相应的羧酸。该过程在适度的温度下进行，通常在20℃到45℃的范围内，在封闭反应器中进行，需要根据需要引入氧气以维持反应。计算机控制的反应器可以对反应参数进行仔细和可重复的控制。硝酸可以通过蒸馏/蒸发过程或通过扩散透析而得到回收，将水溶液用无机氢氧化物碱化，然后使用过滤（纳滤）装置去除剩余的无机硝酸盐。该方法消除了氧化反应的热控制问题，减少了氮排放到大气中的问题，以及后续处理中的硝酸和无机硝酸盐的去除困难。
• Method of Oxidization Using Nitric Acid
  申请人：Kiely Donald E.

  公开号：US20100191002A1

  公开（公告）日：2010-07-29

  A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20° C. to 45° C. in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation/evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.

  采用氧气和硝酸作为共同氧化剂的控制硝酸过程被用于氧化受硝酸氧化的有机化合物，使其转化为相应的羧酸。该过程在适中的温度下进行，通常在20℃到45℃的范围内，在封闭反应器中进行，需要根据需要引入氧气气体来维持反应。计算机控制的反应器可以对反应参数进行仔细和可重复的控制。硝酸可以通过蒸馏/蒸发过程或扩散透析法回收，将水溶液用无机羟基碱性化，然后使用过滤（纳滤）装置去除残留的无机硝酸盐。该方法消除了氧化反应的热控制问题、氮排放问题以及后续处理中的硝酸和无机硝酸盐去除困难。
• Method of oxidation using nitric acid
  申请人：The University of Montana

  公开号：US09162959B2

  公开（公告）日：2015-10-20

  A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20° C. to 45° C. in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation/evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.

  使用氧气和硝酸作为共同氧化剂的受控硝酸过程用于氧化有机化合物，将它们氧化为相应的羧酸。通过该过程，一些碳水化合物的氧化可以产生其一个或多个相应的酸形式。该过程在适中的温度下进行，通常在20℃至45℃的范围内，在封闭反应器中进行，需要根据需要引入氧气气体以维持反应。计算机控制的反应器可以对反应参数进行谨慎和可重复的控制。硝酸可以通过蒸馏/蒸发过程或扩散透析来回收，其中无机氢氧化物使水溶液变为碱性，并使用过滤（纳滤）装置去除残留的无机硝酸盐。该方法消除了氧化的热控制、氮释放到大气中以及后处理中去除硝酸和无机硝酸盐的困难问题。
• METHOD OF OXIDATION USING NITRIC ACID
  申请人：The University of Montana

  公开号：US20160229783A1

  公开（公告）日：2016-08-11

  A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20° C. to 45° C. in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation/evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.

  使用氧气和硝酸作为共同氧化剂的控制硝酸过程用于将有机化合物氧化为相应的羧酸。该过程可通过氧化某些碳水化合物而产生它们的一个或多个相应的酸形式。该过程在适度的温度下进行，通常在20℃到45℃的范围内，在封闭反应器中进行，需要根据需要向反应室引入氧气以维持反应。计算机控制的反应器允许对反应参数进行精细和可重复的控制。硝酸可以通过蒸馏/蒸发过程或扩散透析法回收，其中无机羟化物使水溶液变碱性，并使用过滤（纳滤）装置去除剩余的无机硝酸盐。该方法消除了氧化反应的热控制问题，减少了氮排放，以及后处理中硝酸和无机硝酸盐的去除困难。