spiro[5-O-tert-butyldimethylsilyl-3-deoxy-1,2-isopropylidene-α-D-ribofuranose-3,3'-(3'-hydro-4'-methyl-5'-phenyl-spiro[cyclopropane-1,2'-pyrrolo[1,2-a]imidazole])] | 1355966-04-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: spiro[5-O-tert-butyldimethylsilyl-3-deoxy-1,2-isopropylidene-α-D-ribofuranose-3,3'-(3'-hydro-4'-methyl-5'-phenyl-spiro[cyclopropane-1,2'-pyrrolo[1,2-a]imidazole])]
• CAS: 1355966-04-9
• 化学式: C₂₅H₃₈N₂O₄Si
• 分子量: 458.673
• InChiKey: AAZCCFPMGIUEMN-XDSPWSPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.55
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  52.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-O-(tert-butyldimethylsilyl)-1,2-O-isopropylidene-α-D-erythro-pentofuranos-3-ulose 在 吡啶 、 titanium(IV) isopropylate 、 4-二甲氨基吡啶 、 METHYLTITANIUM TRIISOPROPOXIDE 、 氨 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 丙酮 为溶剂， 反应 9.0h， 生成 spiro[5-O-tert-butyldimethylsilyl-3-deoxy-1,2-isopropylidene-α-D-ribofuranose-3,3'-(3'-hydro-4'-methyl-5'-phenyl-spiro[cyclopropane-1,2'-pyrrolo[1,2-a]imidazole])]
  参考文献：
  名称：

  Reactivity of sugar α-aminonitrile derivatives under titanium-mediated cyclopropanation conditions

  摘要：

  The reactivity of different sugar alpha-aminonitriles has been studied under titanium-mediated cyclo-propanation conditions. This study has been performed on amide, lactam, and imide derivatives. It has been possible to obtain spiro[furanose-3,3'-(3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-pyrrolo[1,2-a] imidazole])] derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.067

文献信息

• Reactivity of sugar α-aminonitrile derivatives under titanium-mediated cyclopropanation conditions
  作者：Delphine Declerck、Solen Josse、Albert Nguyen Van Nhien、Jan Szymoniak、Philippe Bertus、Denis Postel

  DOI：10.1016/j.tet.2011.11.067

  日期：2012.1

  The reactivity of different sugar alpha-aminonitriles has been studied under titanium-mediated cyclo-propanation conditions. This study has been performed on amide, lactam, and imide derivatives. It has been possible to obtain spiro[furanose-3,3'-(3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-pyrrolo[1,2-a] imidazole])] derivatives. (C) 2011 Elsevier Ltd. All rights reserved.