4-(2-呋喃并yl氨基)苯甲酸 | 5768-34-3

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2-呋喃并yl氨基)苯甲酸
• 英文名称: 4-(furan-2-carboxamido)benzoic acid
• 英文别名: 4-(2-Furoylamino)benzoic acid；4-(furan-2-carbonylamino)benzoic acid
• CAS: 5768-34-3
• 化学式: C₁₂H₉NO₄
• mdl: MFCD00522706
• 分子量: 231.208
• InChiKey: LKSXLVUUFLNDSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.5
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2932190090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温

SDS

4-(呋喃-2-甲酰氨基)苯甲酸MSDS英文版

反应信息

• 作为反应物：
  描述：

  4-(2-呋喃并yl氨基)苯甲酸 在 氯化亚砜 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 生成 N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺
  参考文献：
  名称：

  Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine

  摘要：

  Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acylation of various amines to yield the corresponding diamides. Reaction of [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine with chlorides of N-substituted p-aminobenzoic acids has led to formation of diamides.

  DOI：

  10.1134/s1070363215050096
• 作为产物：
  描述：

  呋喃甲酰氯 、 对氨基苯甲酸 在 吡啶 作用下， 以89%的产率得到4-(2-呋喃并yl氨基)苯甲酸
  参考文献：
  名称：

  Iftikhar, Kiran; Murtaza, Shahzad; Kousar, Naghmana, Acta poloniae pharmaceutica, 2018, vol. 75, # 2, p. 385 - 396

  摘要：

  DOI：

文献信息

• LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：Chi Mei Corporation

  公开号：US20170152443A1

  公开（公告）日：2017-06-01

  A liquid crystal alignment agent allowing formation of an LCD element having good reliability and less residual image, a liquid crystal alignment film, and an LCD element having the liquid crystal alignment film are shown. The liquid crystal alignment agent includes a polymer (A), a photosensitive polysiloxane (B), and a solvent (C). The polymer (A) is obtained by reacting a mixture that includes a tetracarboxylic dianhydride component (a-1) and a diamine component (a-2). The photosensitive polysiloxane (B) is obtained by reacting a polysiloxane (b-1) having an epoxy group with a cinnamic acid derivative (b-2) and an aromatic heterocyclic derivative (b-3) containing nitride, oxide or sulfide.
• [EN] WNT PATHWAY INHIBITORS<br/>[FR] INHIBITEURS DE LA VOIE WNT
  申请人：OSLO UNIVERSITY HOSPITAL HF

  公开号：WO2013093508A2

  公开（公告）日：2013-06-27

  Wnt pathway inhibitors A class of compounds having general formula (I) has been identified. These compounds function as inhibitors of the Wnt pathway. Compounds of formula (I) are suitable for the treatment and/or prevention of any condition or disease in which it is desirable to inhibit signaling in the Wnt pathway, in particular inhibiting the proliferation of tumor cells, especially those associated with breast cancer, non-small cell lung cancer, pancreatic and colorectal cancers (e.g. colon carcinoma cells). The compounds also find use in methods of preventing metastasis and methods of promoting and/or directing cellular differentiation of progenitor cells.
• [EN] METHOD FOR PREPARING WATER-SOLUBLE ACRYLIC-MODIFIED PHENOLIC-MODIFIED EPOXY RESIN, WATER-SOLUBLE ACRYLIC-MODIFIED PHENOLIC-MODIFIED EPOXY RESIN PREPARED THEREBY, AND AQUEOUS COATING COMPOSITION COMPRISING SAME<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UNE RÉSINE ÉPOXYDE MODIFIÉE PHÉNOLIQUE ET MODIFIÉE ACRYLIQUE HYDROSOLUBLE, RÉSINE ÉPOXYDE MODIFIÉE PHÉNOLIQUE ET MODIFIÉE ACRYLIQUE HYDROSOLUBLE PRÉPARÉE PAR CE PROCÉDÉ, ET COMPOSITION DE REVÊTEMENT AQUEUSE COMPRENANT CELLE-CI<br/>[KO] 수용성 아크릴-변성 페놀계-변성 에폭시 수지의 제조 방법, 이에 의해 제조된 수용성 아크릴-변성 페놀계-변성 에폭시 수지, 및 이를 포함하는 수성 도료 조성물
  申请人：SAMHWA PAINTS IND CO LTD

  公开号：WO2021075800A1

  公开（公告）日：2021-04-22

  본 발명에 따르면, 카르복실산기를 함유하는 아크릴 공중합체 수지를 제조하고; 에폭시 수지를 페놀계 화합물과 반응시켜 페놀계-변성 에폭시 수지를 제조하고; 상기 아크릴 공중합체 수지와 상기 페놀계-변성 에폭시 수지를 에스테르 반응시켜 아크릴-변성 페놀계-변성 에폭시 수지를 제조하고; 이를 중화하여 수용성 아크릴-변성 페놀계-변성 에폭시 수지를 제조하는 것을 포함하는, 수용성 아크릴-변성 페놀계-변성 에폭시 수지의 제조 방법, 이에 의해 제조된 수용성 아크릴-변성 페놀계-변성 에폭시 수지, 이를 포함하는 수성 도료 조성물이 제공된다. 본 발명에 따른 수용성 아크릴-변성 페놀계-변성 에폭시 수지 및 이를 포함하는 수성 도료 조성물은 여러가지 물성이 우수하여, 에폭시 수지가 사용되는 종래의 용도에 대부분 적용할 수 있을 뿐만 아니라, 형성된 도막은 후성형 가공성, 내용물에 화학적 안정성, 고온에서의 열적 안정성이 우수하여, 2 피스 캔 두껑 내면 및 EOE 내외면용 수성 도료 조성물로 유용하게 적용될 수 있다.
• Iftikhar, Kiran; Murtaza, Shahzad; Kousar, Naghmana, Acta poloniae pharmaceutica, 2018, vol. 75, # 2, p. 385 - 396
  作者：Iftikhar, Kiran、Murtaza, Shahzad、Kousar, Naghmana、Abbas, Aadil、Tahir, Muhammad Nawaz

  DOI：——

  日期：——
• Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine
  作者：A. A. Agekyan、G. G. Mkryan

  DOI：10.1134/s1070363215050096

  日期：2015.5

  Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acylation of various amines to yield the corresponding diamides. Reaction of [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine with chlorides of N-substituted p-aminobenzoic acids has led to formation of diamides.