The present invention is concerned with novel triazole compounds of formula (I)
wherein A, X, Y, Z, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
本发明涉及一种新型的三唑类化合物,其
化学式为(I),其中A,X,Y,Z,R1,R2和R3如本文所述,以及其药学上可接受的盐和酯。本发明的活性化合物具有对
GABA A α5受体的亲和力和选择性。此外,本发明涉及化合物(I)的制造,包括它们的药物组合物和它们作为药物的用途。