8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine | 1578244-55-9

分子结构分类

有机化合物 - 有机杂环化合物 - 唑类

中文名称

——

中文别名

——

英文名称

8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

英文别名

8-chloro-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidin-2-amine

8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine化学式

CAS

1578244-55-9

化学式

C₁₈H₁₅ClN₆O

mdl

——

分子量

366.81

InChiKey

BJCHQKHADDNONL-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

615.0±65.0 °C(Predicted)
密度：

1.42±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

辛醇/水分配系数(LogP)：

3.2
重原子数：

26
可旋转键数：

4
环数：

4.0
sp3杂化的碳原子比例：

0.11
拓扑面积：

77.8
氢给体数：

1
氢受体数：

6

上下游信息

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-methylpyrido[3,4-d]pyrimidine-2,8-diamine	1578244-72-0	C₁₉H₁₉N₇O	361.406
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8,N8-dimethylpyrido[3,4-d]pyrimidine-2,8-diamine	1578244-69-5	C₂₀H₂₁N₇O	375.433
——	N8-(tert-butyl)-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-42-4	C₂₂H₂₅N₇O	403.487
——	N⁸-isobutyl-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidine-2,8-diamine	1578244-22-0	C₂₂H₂₅N₇O	403.487
——	N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine	1578244-25-3	C₂₃H₂₇N₇O	417.514
——	N8-isopentyl-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-17-3	C₂₃H₂₇N₇O	417.514
——	N⁸-cyclopropylmethyl-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-15-1	C₂₂H₂₃N₇O	401.471
——	N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-phenylpyrido[3,4-d]pyrimidin-2-amine	1578243-91-0	C₂₄H₂₀N₆O	408.462
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-(2,2,2-trifluoroethyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-48-0	C₂₀H₁₈F₃N₇O	429.404
——	2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol	1578244-91-3	C₂₁H₂₃N₇O₂	405.459
——	2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-1-ol	1578244-76-4	C₂₂H₂₅N₇O₂	419.486
——	N8-(3,3-dimethylbutan-2-yl)-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-30-0	C₂₄H₂₉N₇O	431.541
N8-[(2S)-3,3-二甲基丁烷-2-基]-N2-[2-甲氧基-4-(1-甲基-1H-吡唑-4-基)苯基]吡啶基[3,4-d]嘧啶-2,8-二胺	(S)-N⁸-(3,3-dimethylbutan-2-yl)-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-34-4	C₂₄H₂₉N₇O	431.541
——	(R)-N⁸-(3,3-dimethylbutan-2-yl)-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-33-3	C₂₄H₂₉N₇O	431.541
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-(oxetan-3-yl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-73-1	C₂₁H₂₁N₇O₂	403.443
——	1-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-2-ol	1578244-28-6	C₂₂H₂₅N₇O₂	419.486
——	N8-(2,2-difluoropropyl)-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-45-7	C₂₁H₂₁F₂N₇O	425.441
——	N⁸-cyclohexyl-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-12-8	C₂₄H₂₇N₇O	429.525
——	3-methoxy-2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol	1578244-93-5	C₂₂H₂₅N₇O₃	435.486
——	N⁸-cyclohexylmethyl-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-27-5	C₂₅H₂₉N₇O	443.552
——	N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(pyrimidin-5-yl)pyrido[3,4-d]pyrimidin-2-amine	1578245-71-2	C₂₂H₁₈N₈O	410.438
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-((tetrahydrofuran-3-yl)methyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-38-8	C₂₃H₂₅N₇O₂	431.497
——	N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N⁸-(tetrahydro-2H-pyran-4-yl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-26-4	C₂₃H₂₅N₇O₂	431.497
——	(±)-N-(2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenylamino)pyrido[3,4-d]pyrimidin-8-yl)-2-methylpropane-2-sulfinamide	1578245-05-2	C₂₂H₂₅N₇O₂S	451.552
——	N⁸-(2-methoxy-2-methylpropyl)-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-47-9	C₂₃H₂₇N₇O₂	433.513
——	8-(cyclohexylthio)-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine	1578244-51-5	C₂₄H₂₆N₆OS	446.576
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-(1-methylpiperidin-4-yl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-75-3	C₂₄H₂₈N₈O	444.539
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-(oxetan-2-ylmethyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-78-6	C₂₂H₂₃N₇O₂	417.47
——	N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(piperidin-1-yl)pyrido[3,4-d]pyrimidin-2-amine	1578244-11-7	C₂₃H₂₅N₇O	415.498
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-(1-methylcyclohexyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-44-6	C₂₅H₂₉N₇O	443.552
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-((3-methyltetrahydrofuran-3-yl)methyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-79-7	C₂₄H₂₇N₇O₂	445.524
——	(S)-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-((3-methyltetrahydrofuran-3-yl)methyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578245-03-0	C₂₄H₂₇N₇O₂	445.524
——	(R)-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-((3-methyltetrahydrofuran-3-yl)methyl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578245-04-1	C₂₄H₂₇N₇O₂	445.524
——	N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N8-(tetrahydrofuran-3-yl)pyrido[3,4-d]pyrimidine-2,8-diamine	1578244-36-6	C₂₂H₂₃N₇O₂	417.47
——	N-(2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenylamino)pyrido[3,4-d]pyrimidin-8-yl)-2-methylpropane-2-sulfonamide	1578244-68-4	C₂₂H₂₅N₇O₃S	467.552