5,7-二甲基-[1,2,4]噻唑并[1,5-a]嘧啶-2-氢硫化物 | 51646-17-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 中文名称: 5,7-二甲基-[1,2,4]噻唑并[1,5-a]嘧啶-2-氢硫化物
• 英文名称: 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol
• 英文别名: 2-mercapto-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine；5,7-dimethyl-1H-[1,2,4]triazolo[1,5-a]pyrimidine-2-thione
• CAS: 51646-17-4
• 化学式: C₇H₈N₄S
• mdl: MFCD00068128
• 分子量: 180.233
• InChiKey: PZXUJTDXOFHNKC-UHFFFAOYSA-N

物化性质

• 熔点：
  256°
• 沸点：
  256°C

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  72.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5,7-二甲基-[1,2,4]噻唑并[1,5-a]嘧啶-2-氢硫化物 在 一水合肼 、 potassium hydroxide 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 32.0h， 生成 potassium 2-(2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)acetyl)hydrazinecarbodithioate
  参考文献：
  名称：

  Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: Derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety

  摘要：

  A series of novel 1,3,4-thiadiazole derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety were synthesized by the method of splicing active substructures. Among these derivatives, compounds 12,13,15-22 and 24-31 were firstly reported. All the compounds were assayed for antimicrobial activities against five fungi strains and four bacteria strains. The preliminary results indicated that compounds 25 and 28-31 showed good antifungal activities against Physaclospora piricola and Rhizoctonia solani. Compound 26 exhibited good antifungal activities against Cercospora beticola and R. solani. Most of the compounds showed better antibacterial activities against Gram-negative bacteria strains than Gram-positive bacteria strains. Compounds 25 and 28 showed the best activities against Pseudomonas fluorescence while compounds 30-31 showed good activities against Escherichia coli. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.04.014
• 作为产物：
  描述：

  2,5-二硫代联二脲 、 乙酰丙酮 在 盐酸 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 5,7-二甲基-[1,2,4]噻唑并[1,5-a]嘧啶-2-氢硫化物
  参考文献：
  名称：

  Chen; Xiang; Fu, Asian Journal of Chemistry, 2011, vol. 23, # 2, p. 602 - 608

  摘要：

  DOI：

文献信息

• SUBSTITUTED TRIAZOLO-PYRIMIDINE COMPOUNDS FOR MODULATING CELL PROLIFERATION, DIFFERENTIATION AND SURVIVAL
  申请人：STATegics, Inc.

  公开号：US20140142122A1

  公开（公告）日：2014-05-22

  Disclosed herein are erythropoietin-mimetic compounds of Formula I, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor. The compounds of the invention are useful in preventing and treating diseases, such as anemia, organ injury, and diseases of the central nervous system, and as an adjunct to cellular treatments, such as stem cell therapies.

  本公开涉及的是式I的类似促红细胞生成素化合物，其调节肾脏细胞、神经元、红细胞或其他促红细胞生成素反应细胞的存活、功能或分化。本发明还涉及优先调节表达组织保护性促红细胞生成素受体的细胞的化合物和方法。本发明的化合物在预防和治疗贫血、器官损伤、中枢神经系统疾病等疾病方面有用，并可作为干细胞治疗等细胞治疗的辅助手段。
• Novel substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides and
  申请人：The Dow Chemical Company

  公开号：US04755212A1

  公开（公告）日：1988-07-05

  Novel compounds, e.g., 5,7-dimethyl-N-(2,6-dichlorolphenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sul fonamide and their compositions and use in the control of weeds and in the suppression of nitrification of ammonium nitrogen in soil. Other novel compounds and their compositions and use in the inhibition of bolting in sugar beets. Other novel compounds and their compositions and use as plant gametocides.

  新型化合物，例如5,7-二甲基-N-(2,6-二氯苯基)-1,2,4-三唑[1,5-a]嘧啶-2-磺酰胺及其组合物，用于控制杂草以及在土壤中抑制铵氮的硝化。其他新型化合物及其组合物用于抑制甜菜的抽苔。其他新型化合物及其组合物用作植物配子体杀虫剂。
• Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions
  申请人：The Dow Chemical Company

  公开号：US04818273A1

  公开（公告）日：1989-04-04

  Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonamides, e.g., 5,7-dimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulf onamide and their agriculturally acceptable salts are prepared. These compounds and compositions containing them are useful for the control of unwanted vegetation. Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonyl chlorides and substituted anilines and their use as intermediates are also described.

  新型取代的 triazolo[1,5-a]pyrimidine-2-磺酰胺，例如，5,7-二甲基-N-(2,6-二氯苯基)-1,2,4-三唑[1,5-a]pyrimidine-2-磺酰胺及其农业上可接受的盐类被制备。这些化合物和含有它们的组合物对于控制不需要的植被是有用的。还描述了新型的取代 triazolo[1,5-a]pyrimidine-2-磺酰氯和取代苯胺及其作为中间体的使用。
• [EN] INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME<br/>[FR] INHIBITEURS DE L'ARN POLYMERASE ARN-DEPENDANTE DU VIRUS DE L'HEPATITE C ET COMPOSITIONS ET TRAITEMENTS UTILISANT CETTE POLYMERASE
  申请人：PFIZER

  公开号：WO2003095441A1

  公开（公告）日：2003-11-20

  Compounds of formula (I) are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus.

  化合物的化学式（I）是丙型肝炎病毒（HCV）RNA依赖性RNA聚合酶（RdRp）抑制剂，对感染丙型肝炎病毒的人进行治疗和预防性治疗具有用处。
• [EN] ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS<br/>[FR] COMPOSÉS ANTINÉOPLASIQUES, COMPOSITIONS ET PROCÉDÉS
  申请人：PROGENRA INC

  公开号：WO2010114881A1

  公开（公告）日：2010-10-07

  Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.

  公开的是新型化合物，这些化合物在治疗上具有用途，特别是在抗肿瘤治疗和其他涉及半胱氨酸蛋白酶抑制的治疗方案中。