5,7-dimethyl-2-[(2-phenoxyethyl)sulfanyl]-[1,2,4]triazolo[1,5-a]pyrimidine | 866142-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: 5,7-dimethyl-2-[(2-phenoxyethyl)sulfanyl]-[1,2,4]triazolo[1,5-a]pyrimidine
• 英文别名: 5,7-Dimethyl-2-[(2-phenoxyethyl)sulfanyl][1,2,4]triazolo[1,5-a]pyrimidine；5,7-dimethyl-2-(2-phenoxyethylsulfanyl)-[1,2,4]triazolo[1,5-a]pyrimidine
• CAS: 866142-71-4
• 化学式: C₁₅H₁₆N₄OS
• 分子量: 300.384
• InChiKey: PFHALZMAJQIQSS-UHFFFAOYSA-N

物化性质

• 密度：
  1.29±0.1 g/cm3(Predicted)
• 溶解度：
  38.9 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  77.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,7-dimethyl-2-[(2-phenoxyethyl)sulfanyl]-[1,2,4]triazolo[1,5-a]pyrimidine 在 dithio ether 、 碘苯二乙酸 、 碳酸氢铵 作用下， 以 甲醇 为溶剂， 以57 %的产率得到(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)(imino)(2-phenoxyethyl)-λ6-sulfanone
  参考文献：
  名称：

  Mitsunobu 型条件下 NH-亚砜亚胺的烷基化

  摘要：

  先前描述的N H-亚砜亚胺烷基化方法通常依赖于过渡金属催化，或使用传统的烷基化试剂和强碱。在此，我们报道了多种N H-亚砜亚胺在简单 Mitsunobu 型条件下的直接烷基化，尽管N H中心的pKa异常高。

  DOI：

  10.1039/d3ob00810j
• 作为产物：
  描述：

  5,7-二甲基-[1,2,4]噻唑并[1,5-a]嘧啶-2-氢硫化物 、 2-苯氧乙基溴 生成 5,7-dimethyl-2-[(2-phenoxyethyl)sulfanyl]-[1,2,4]triazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  SUBSTITUTED TRIAZOLO-PYRIMIDINE COMPOUNDS FOR MODULATING CELL PROLIFERATION, DIFFERENTIATION AND SURVIVAL

  摘要：

  本发明涉及式I的类似促红细胞生成素化合物，其调节肾细胞、神经元、红细胞或其他对促红细胞生成素具有反应性的细胞的存活、功能或分化。本发明还涉及偏好调节表达组织保护性促红细胞生成素受体的细胞的化合物和方法。本发明的化合物可用于预防和治疗贫血、器官损伤和中枢神经系统疾病，并作为细胞治疗的辅助手段，例如干细胞治疗。

  公开号：

  US20140142122A1

文献信息

• Substituted triazolo-pyrimidine compounds for modulating cell proliferation differentiation and survival
  申请人：STATegics, Inc.

  公开号：US09163027B2

  公开（公告）日：2015-10-20

  Disclosed herein are erythropoietin-mimetic compounds of Formula I, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor. The compounds of the invention are useful in preventing and treating diseases, such as anemia, organ injury, and diseases of the central nervous system, and as an adjunct to cellular treatments, such as stem cell therapies.

  本文披露了公式I的类似促红细胞生成素化合物，它们可以调节肾细胞、神经元、红细胞或其他对促红细胞生成素敏感的细胞的生存、功能或分化。本发明还涉及优先调节表达组织保护性促红细胞生成素受体的细胞的化合物和方法。本发明的化合物可用于预防和治疗贫血、器官损伤和中枢神经系统疾病，并作为细胞治疗（如干细胞治疗）的辅助治疗。
• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying And Using The Same
  申请人：Huang Qihong

  公开号：US20120010177A1

  公开（公告）日：2012-01-12

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying and Using the Same
  申请人：Huang Qihong

  公开号：US20130023498A1

  公开（公告）日：2013-01-24

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• US20140255386A1
  申请人：——

  公开号：US20140255386A1

  公开（公告）日：2014-09-11