N-(2,6-二氯苯基)-5,7-二甲基[1,2,4]三唑并[1,5-a]嘧啶-2-磺酰胺 | 98937-00-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 中文名称: N-(2,6-二氯苯基)-5,7-二甲基[1,2,4]三唑并[1,5-a]嘧啶-2-磺酰胺
• 英文名称: FBS-08215
• 英文别名: 5,7-di-methyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide；N-(2,6-dichlorophenyl)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide；N-(2,6-dichlorphenyl)-5.7-dimethyl[1,2,4]triazolo [1.5-A]pyrimidin-2-sulfonamide；N-(2,6-dichlorophenyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
• CAS: 98937-00-9
• 化学式: C₁₃H₁₁Cl₂N₅O₂S
• 分子量: 372.235
• InChiKey: RZWWGOCLMSGROE-UHFFFAOYSA-N

物化性质

• 熔点：
  263-265 °C(Solv: acetonitrile (75-05-8))
• 密度：
  1.66±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  97.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(2,6-二氯苯基)-5,7-二甲基[1,2,4]三唑并[1,5-a]嘧啶-2-磺酰胺 生成 5,7-Dimethyl-N-(2,6-dichlorophenyl)-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide
  参考文献：
  名称：

  KLESCHICK, WILLIAM A.;EHR, ROBERT J.;GERWICK, BEN C.;MONTE, WILLIAM T.;PE+

  摘要：

  DOI：
• 作为产物：
  描述：

  5,7-二甲基[1,2,4]三唑并[1,5-a]嘧啶-2-磺酰氯 生成 N-(2,6-二氯苯基)-5,7-二甲基[1,2,4]三唑并[1,5-a]嘧啶-2-磺酰胺
  参考文献：
  名称：

  KLESCHICK, WILLIAM A.;EHR, ROBERT J.;GERWICK, BEN C.;MONTE, WILLIAM T.;PE+

  摘要：

  DOI：

文献信息

• Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions
  申请人：The Dow Chemical Company

  公开号：US04818273A1

  公开（公告）日：1989-04-04

  Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonamides, e.g., 5,7-dimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulf onamide and their agriculturally acceptable salts are prepared. These compounds and compositions containing them are useful for the control of unwanted vegetation. Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonyl chlorides and substituted anilines and their use as intermediates are also described.

  新型取代的 triazolo[1,5-a]pyrimidine-2-磺酰胺，例如，5,7-二甲基-N-(2,6-二氯苯基)-1,2,4-三唑[1,5-a]pyrimidine-2-磺酰胺及其农业上可接受的盐类被制备。这些化合物和含有它们的组合物对于控制不需要的植被是有用的。还描述了新型的取代 triazolo[1,5-a]pyrimidine-2-磺酰氯和取代苯胺及其作为中间体的使用。
• Preparation of substituted
  申请人：The Dow Chemical Company

  公开号：US04910306A1

  公开（公告）日：1990-03-20

  Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides, which are known herbicides, are prepared by the reaction of substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonyl halides with substituted N-trialkylsilylanilines in the presence of a base catalyst. The method is especially useful for the preparation of substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides derived from substituted anilines having both 2- and 6-substituents, at least one of which is electron withdrawing, such as N-(2,6-dichlorophenyl)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-sulf onamide. N-trialkylsilylanilines having both 2- and 2-substituents, at least one of which is electron withdrawing, such as N-trimethylsilyl-2,6-dichloro-3-methylaniline, are described.

  已知的除草剂替代了1,2,4-三唑并[1,5-a]嘧啶-2-磺酰卤代物，通过在碱催化剂存在下，与取代的N-三烷基硅基苯胺反应制备。该方法特别适用于制备来自具有2-和6-取代基的取代苯胺的替代1,2,4-三唑并[1,5-a]嘧啶-2-磺酰苯胺衍生物，其中至少有一个是电子吸引基，例如N-(2,6-二氯苯基)-5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-磺酰胺。还描述了具有2-和2-取代基的N-三烷基硅基苯胺，其中至少有一个是电子吸引基，例如N-三甲基硅基-2,6-二氯-3-甲基苯胺。
• Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonyl chlorides
  申请人：The Dow Chemical Company

  公开号：US04886883A1

  公开（公告）日：1989-12-12

  Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonamides, e.g., 5,7-dimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulf onamide and their agriculturally acceptable salt are prepared. These compounds and compositions containing them are useful for the control of unwanted vegetation. Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonyl chlorides and substituted anilines and their use as intermediates are also described.

  制备了新型的取代的三唑并[1,5-a]嘧啶-2-磺酰胺，例如5,7-二甲基-N-(2,6-二氯苯基)-1,2,4-三唑并[1,5-a]嘧啶-2-磺酰胺及其农业上可接受的盐。这些化合物和含有它们的组合物对于控制不必要的植被是有用的。还描述了新型的取代的三唑并[1,5-a]嘧啶-2-磺酰氯和取代的苯胺及其用作中间体的用途。
• Novel sulfonamides and method of making
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0244847A1

  公开（公告）日：1987-11-11

  N-aryl-5,6,7-substituted-1,2,4-triazolo-[1,5a]­pyrimidine-2-sulfonamides undergo oxidative ring cleavage to afford herbicidal substituted N-aryl-5-­amino-1,2,4-triazole-3-sulfonamides. These triazolesulfonamides can undergo cyclizations with 1,3-­dicarbonyls to form novel herbicidal substituted N-­aryl-5,6,7-substituted-1,2,4-tri- azolo-[1,5a]­pyrimidine-2-sulfonamides.

  N-芳基-5,6,7-取代的-1,2,4-三唑-[1,5a]嘧啶-2-磺酰胺类化合物经过氧化环裂解后，可得到除草取代的 N-芳基-5-氨基-1,2,4-三唑-3-磺酰胺类化合物。这些三唑磺酰胺可与 1,3-二羰基发生环化反应，生成新型除草取代的 N-芳基-5,6,7-取代-1,2,4-三唑-[1,5a]嘧啶-2-磺酰胺。
• Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0257993A2

  公开（公告）日：1988-03-02

  A nucleic acid fragment encoding a herbicide-resistant plant acetolactate synthase protein is disclosed. This nucleic acid fragment contains at least one nucleotide mutation resulting in one amino acid change in one of seven substantially conserved regions of acetolactate synthase amino acid homology. This mutation results in the production of an acetolactate synthase protein which is resistant to sulfonylurea herbicide compounds compared to the wild-type protein. Transformation of herbicide sensitive plants or plant cells with the fragment results in resistance to the herbicide.

  本研究公开了一种编码抗除草剂植物乙酰乳酸合成酶蛋白的核酸片段。该核酸片段含有至少一个核苷酸突变，导致乙酰乳酸合成酶氨基酸同源的七个基本保守区域之一的一个氨基酸发生变化。与野生型蛋白相比，这种突变产生的乙酰乳酸合成酶蛋白对磺酰脲类除草剂化合物具有抗性。用该片段转化对除草剂敏感的植物或植物细胞，可产生对除草剂的抗性。