lanosta-8,24-dien-3α-ol | 76582-59-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: lanosta-8,24-dien-3α-ol
• 英文别名: 3α-lanosterol；lanosta-8,24-diene-3α-ol；(3R,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 76582-59-7
• 化学式: C₃₀H₅₀O
• 分子量: 426.726
• InChiKey: CAHGCLMLTWQZNJ-QPSCWZJHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  lanosta-8,24-dien-3α-ol 在 platinum(IV) oxide 吡啶 、 氢气 作用下， 生成 4,4-Dimethyl-5α-cholest-8-en3α-yl-acetat
  参考文献：
  名称：

  645. 4,4,14的一些反应α-三甲基-5- α -胆甾-8,24-二烯-3- α -基和-3β基甲苯p -sulphonates

  摘要：

  DOI：

  10.1039/jr9610003295
• 作为产物：
  描述：

  lanosta-8,24-dien-3-one 生成 lanosta-8,24-dien-3α-ol
  参考文献：
  名称：

  645. 4,4,14的一些反应α-三甲基-5- α -胆甾-8,24-二烯-3- α -基和-3β基甲苯p -sulphonates

  摘要：

  DOI：

  10.1039/jr9610003295

文献信息

• A Well-Defined Monomeric Aluminum Complex as an Efficient and General Catalyst in the Meerwein-Ponndorf-Verley Reduction
  作者：Brian McNerney、Bruce Whittlesey、David B. Cordes、Clemens Krempner

  DOI：10.1002/chem.201404994

  日期：2014.11.10

  sustainable reduction of aldehydes and ketones but has not found widespread application in organic synthesis due to the high catalyst loading often required to obtain satisfactory yields of the reduced product. We report here on the synthesis and structure of a sterically extremely overloaded siloxide‐supported aluminum isopropoxide capable of catalytically reducing a wide range of aldehydes and ketones (52

  金属催化的Meerwein-Ponndorf-Verley（MPV）还原可缓慢且可持续地还原醛和酮，但由于通常需要高催化剂负载才能获得令人满意的还原产物收率，因此尚未在有机合成中得到广泛应用。我们在此报告了一种在空间上极度超载，由氧化硅负载的异丙醇铝的合成和结构，该催化剂能够在温和的条件下以较低的催化剂负载量以优异的收率催化还原多种醛和酮（52个实例）。发达的催化剂体系在MPV还原中看不见的活性是由于其独特的单体性质以及中性的供体异丙醇与铝中心的配位较弱。
• Sterol C24-methyltransferase: Physio- and stereo-chemical features of the sterol C3 group required for catalytic competence
  作者：Alicia L. Howard、Jialin Liu、Gamal A. Elmegeed、Emily K. Collins、Kalgi S. Ganatra、Chizaram A. Nwogwugwu、W. David Nes

  DOI：10.1016/j.abb.2012.03.002

  日期：2012.5

  3-OMe, 3β-F, 3β-NH(2) (protonated species) or 3H group revealed that lanosterol and five substrate analogs were catalyzed and yielded identical side chain products whereas neither the 3H- or 3α-OH lanosterol derivatives were productively bound. Taken together, our results demonstrate a chemical complementarity involving hydrogen bonding formation of specific active site contacts to the nucleophilic C3-group

  甾醇C24-甲基转移酶（24-SMT）催化Δ（24）-甾醇向各种甾醇侧链结构的亲电烷基化，C3-部分是这些酶与底物结合的主要决定因素。为了确定C3极性基团的哪些特定结构特征可确保固醇催化，针对来自巴西副球菌（Paracoccidioides brasiliensis（Pb））的真菌24-SMT，研究了一系列在立体化学，体积和电子性质方面不同的羊毛甾醇的C3类似物。认识到羊毛甾醇是天然底物。由3β-OH为C3位置变化引起的固醇C24甲基化活性的大小分析（基于V（max）/ K（m）的动力学常数和由GC-MS确定的产物分布）被3α-OH，3β-乙酰基，3-氧代，3-OMe，3β-F取代，3β-NH（2）（质子化的物种）或3H组显示，羊毛甾醇和五个底物类似物被催化并产生相同的侧链产物，而3H-或3α-OH羊毛甾醇衍生物均未有效结合。两者合计，我们的结果表明，化学上的互补性涉及到氢键形成特定的活性
• NOVEL BOSWELLIA LOW POLAR GUM RESIN EXTRACT AND ITS SYNERGISTIC COMPOSITIONS
  申请人：GOKARAJU Ganga Raju

  公开号：US20120301432A1

  公开（公告）日：2012-11-29

  The present disclosure describes Boswellia low polar gum resin extract (BLPRE) comprising novel phytochemical composition of sesquiterpenes, diterpenes, triterpenes and other phytochemical(s) obtained from gum resin of Boswellia species. The present disclosure also describes compositions comprising BLPRE in combination with one or more component(s) selected from biologically active ingredient(s), functional ingredient(s), excipient(s), diluents(s), carrier(s) and additive(s) or mixtures thereof. Further the present disclosure also provides synergistic composition(s) comprising Boswellia low polar gum resin extract (BLPRE) and at least one component selected from but not limited to extract(s), fraction(s), phytochemical(s) or their salts or mixtures thereof derived from Boswellia species or Curcuma species.

  本公开说明书描述了一种低极性树脂提取物（BLPRE），其包含从乳香树脂中获得的倍半萜、二萜、三萜和其他植物化学物质的新型植物化学成分。本公开说明书还描述了包含BLPRE的组合物，其与生物活性成分、功能性成分、赋形剂、稀释剂、载体和添加剂或其混合物中的一个或多个成分组合使用。此外，本公开说明书还提供了协同作用组合物，其包括乳香低极性树脂提取物（BLPRE）和至少一种从乳香种类或姜黄种类中提取的提取物、分离物、植物化学物质或其盐或混合物，但不限于此。
• Synergistic anti-inflammatory compositions comprising Boswellia serrata extract
  申请人：LAILA NUTRACEUTICALS

  公开号：US10206964B2

  公开（公告）日：2019-02-19

  The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-O-acetyl-1 1-keto-β-boswellic acid (AKBA) derived from Boswellia serrata and Boswellia serrata non-acidic resin extract (BNRE). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, osteoarthritis, rheumatoid arthritis, endothelial dysfunction and the like. The invention further discloses the amelioration of pro-inflammatory biomarker proteins or molecules, whose expression/production is altered during inflammatory diseases.

  本发明公开了协同营养保健品或药物或膳食补充剂抗炎组合物，该组合物包含选择性富含3-O-乙酰基-1 1-酮-β-乳香酸（AKBA）的提取物（来源于血清乳香）和血清乳香非酸性树脂提取物（BNRE）的治疗有效组合。该组合物可用于预防、控制和治疗炎症及多种炎症相关疾病，包括哮喘、骨关节炎、类风湿性关节炎、内皮功能障碍等。本发明进一步揭示了对促炎症生物标志蛋白或分子的改善作用，这些蛋白或分子的表达/产生在炎症性疾病期间会发生改变。
• Compositions comprising non-acidic Boswellia oil fraction as a bio-enhancer for enhancing bioavailability of biological agents
  申请人：LAILA NUTRACEUTICALS

  公开号：US10286023B2

  公开（公告）日：2019-05-14

  The invention relates to a non-acidic Boswellia low polar gum resin extract fraction (BLPRE) in combination with biological agents for enhancing the bioavailability of the biological agents. The invention also provides composition(s) comprising a Boswellia low polar gum resin extract (BLPRE) in combination with a biological agent for increasing the bioavailability of biological agent.

  本发明涉及一种非酸性乳香低极性胶树脂提取物馏分（BLPRE）与生物制剂的组合，用于提高生物制剂的生物利用度。本发明还提供了包含乳香低极性胶树脂提取物（BLPRE）的组合物，该组合物与生物制剂结合使用可提高生物制剂的生物利用度。