sucrose 1'-O-monodecanoate | 123499-66-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sucrose 1'-O-monodecanoate
• 英文别名: 1'-O-Monodecanoyl sucrose；1'-O-decanoylsucrose；6-O-decanoyl-sucrose；1'-O-decylsucrose；n-decanoylsucrose；sucrose caprate；((2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)methyl decanoate；[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl decanoate
• CAS: 123499-66-1
• 化学式: C₂₂H₄₀O₁₂
• 分子量: 496.552
• InChiKey: DSDLUVQAJPJFTK-LUQRLMJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  196
• 氢给体数：
  7
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  3,4,5-tris(benzyloxy)benzoyl chloride 、 sucrose 1'-O-monodecanoate 在 palladium on activated charcoal 4-二甲氨基吡啶 、 三乙胺 、 氢气 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 [(2R,3R,4S,5R,6R)-6-[(2S,3S,4R,5R)-2-(decanoyloxymethyl)-3,4-bis[(3,4,5-trihydroxybenzoyl)oxy]-5-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxolan-2-yl]oxy-3,4,5-tris[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
  参考文献：
  名称：

  Gallic Esters of Sucrose as Efficient Radical Scavengers in Lipid Peroxidation

  摘要：

  Three tests of increasing complexity were used to assess the antioxidant activity of five synthetic gallic esters of sucrose bearing 3, 6, 7, or 8 galloyl units. In addition, two of these compounds had 1 or 2 hydrocarbon (C10-C12) acyl chains. Reaction with the DPPH radical led to the evaluation of the number of radicals trapped per galloyl unit n (3-4), as well as the apparent second-order rate constant for H atom donation k (1200-1500/M/s). These results indicated similar contribution and reactivity of all the galloyl units. Inhibition of the AAPH-initiated peroxidation of linoleic acid in a micellar medium confirmed the additive contribution of the galloyl units, whereas the presence of the hydrocarbon acyl chains had no influence, These results suggest an inhibition of initiation at high antioxidant levels and an underlying prooxidant effect of the galloyl radicals at low concentrations. Finally, LDL peroxidation was inhibited in proportion to the number of galloyl units, in agreement with the preceding tests.

  DOI：

  10.1021/jf011683k
• 作为产物：
  描述：

  2,2,2-trifluoroethyl decanoate 、 蔗糖 在 protease N 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以4%的产率得到sucrose 1'-O-monodecanoate
  参考文献：
  名称：

  Carrea, Giacomo; Riva, Sergio; Secundo, Francesco, Journal of the Chemical Society. Perkin transactions I, 1989, p. 1057 - 1061

  摘要：

  DOI：

文献信息

• NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20170000888A1

  公开（公告）日：2017-01-05

  Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

  描述了包括凝胶剂的自组装凝胶组合物，例如，一种酶可切割的凝胶剂，例如，具有分子量不超过2500的凝胶剂。这些自组装凝胶组合物可以包裹一个或多个药剂。还描述了制备这些自组装凝胶组合物的方法，以及使用这些自组装凝胶组合物进行药物传递的方法。
• PHOTORESPONSIVE LOW-MOLECULAR WEIGHT MATERIAL, ADHESIVE, TONER, AND IMAGE FORMING METHOD
  申请人：KONICA MINOLTA, INC.

  公开号：US20200264530A1

  公开（公告）日：2020-08-20

  Disclosed is a compound containing a specific structure having an azomethine part, the compound being reversibly fluidized and non-fluidized by being irradiated with light.

  揭示了一种含有具有偶氮甲烷部分的特定结构的化合物，该化合物通过光照可逆地使其变流动或非流动。
• Transesterification of Sucrose in Organic Medium: Study of Acyl Group Migrations
  作者：Valérie Molinier、Krzysztof Wisniewski、Alain Bouchu、Juliette Fitremann、Yves Queneau

  DOI：10.1081/car-120026466

  日期：2003.12.31

  of sucrose fatty acid esters to undergo intramolecular migrations in organic medium and the regioselectivity of some transesterifications of sucrose were investigated by HPLC, in situ NMR spectroscopy and preparative methods. Extensive acylation on secondary positions of the glucose moiety followed by migrations is general for base catalysed transesterification. The stability of 3‐ and 6‐O‐acyl derivatives

  通过HPLC，原位NMR光谱和制备方法研究了蔗糖脂肪酸酯的葡萄糖部分上的酰基在有机介质中发生分子内迁移的趋势以及一些蔗糖的酯交换反应的区域选择性。对于碱基催化的酯交换反应，通常在葡萄糖部分的次要位置上进行广泛的酰化，然后进行迁移。在一系列条件下研究了3-和6- O-酰基衍生物的稳定性，这两个异构体在热力学上比其他异构体更受青睐。结果表明，在有机碱性介质中，水的存在会催化OH-3处的酯向OH-6的迁移，而OH-6处的酯在酸性或碱性条件下显得更稳定。
• [EN] COLORING COMPOUND AND INK, COLOR FILTER RESIST COMPOSITION, AND THERMAL TRANSFER RECORDING INK SHEET CONTAINING SAID COLORING COMPOUND<br/>[FR] COMPOSÉ COLORANT ET ENCRE, COMPOSITION DE RÉSERVE DE FILTRE COLORÉ ET FEUILLE D'ENCRAGE D'ENREGISTREMENT PAR TRANSFERT THERMIQUE CONTENANT LEDIT COMPOSÉ COLORANT
  申请人：CANON KK

  公开号：WO2014030767A1

  公开（公告）日：2014-02-27

  The present invention provides a coloring compound that exhibits an excellent chromogenicity and provides an ink, a color filter resist composition, and a thermal transfer recording ink sheet that contain this coloring compound. The coloring compound has the structure represented by general formula (1), and the ink, color filter resist composition, and thermal transfer recording ink sheet contain this coloring compound.

  本发明提供一种表现出优异色素性的着色化合物，以及包含该着色化合物的墨水、彩色滤光片抗蚀组合物和热转印记录墨水片。该着色化合物具有通式（1）所代表的结构，墨水、彩色滤光片抗蚀组合物和热转印记录墨水片中含有该着色化合物。
• Methods of treating diseases responsive to Induction of Apoptosis
  申请人：Kasibhatla Shailaja

  公开号：US20050004005A1

  公开（公告）日：2005-01-06

  The present invention pertains to a method of treating, preventing or ameliorating a disease responsive to induction of the caspase cascade in an animal, comprising administering to the animal a compound which binds specifically to a Tail Interacting Protein Related Apoptosis Inducing Protein (TIPRAIP). The present invention also relates to screening methods useful for drug discovery of apoptosis inducing compounds. In particular, the screening methodology relates to using TIPRAIP as a target for the discovery of apoptosis activators useful as anticancer agents. The screening methods of the present invention can employ homogenous or heterogenous binding assays using purified or partially purified TIPRAIP; or whole cell assays using cells with altered levels of TIPRAIP. The invention also contemplates use of 3-(4-azidophenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole or a substituted 3-aryl-5-aryl-[1,2,4]-oxadiazole which bind TIPRAIP and can accordingly be used to raise antibodies useful for drug discovery. Alternatively, labeled 3-(4-azidophenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole (or a labeled substituted 3-aryl-5-aryl-[1,2,4]-oxadiazole) is used for competitive binding assays for drug discovery. Such assays afford high throughput screening of chemical libraries for apoptosis activators.

  本发明涉及一种用于治疗、预防或改善对Caspase级联诱导敏感的动物疾病的方法，包括向动物投药一种与尾部相互作用蛋白相关凋亡诱导蛋白（TIPRAIP）特异结合的化合物。本发明还涉及有用于药物发现凋亡诱导化合物的筛选方法。特别是，筛选方法涉及使用TIPRAIP作为靶标，以发现作为抗癌剂有用的凋亡激活剂。本发明的筛选方法可以采用使用纯化或部分纯化的TIPRAIP的均相或异相结合分析；或使用具有改变TIPRAIP水平的细胞的全细胞分析。本发明还考虑使用3-（4-偶氮苯基）-5-（3-氯噻吩-2-基）-[1,2,4]-噁二唑或结合TIPRAIP的取代3-芳基-5-芳基-[1,2,4]-噁二唑，可用于制备有用于药物发现的抗体。或者，标记的3-（4-偶氮苯基）-5-（3-氯噻吩-2-基）-[1,2,4]-噁二唑（或标记的取代的3-芳基-5-芳基-[1,2,4]-噁二唑）可用于药物发现的竞争结合分析。这种分析为化学文库的高通量筛选提供了凋亡激活剂。