2-methyl-3-(4-methoxyphenyl)acrylic acid chloride | 109830-34-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-methyl-3-(4-methoxyphenyl)acrylic acid chloride
• 英文别名: 3-(4-Methoxyphenyl)-2-methylprop-2-enoyl chloride
• CAS: 109830-34-4
• 化学式: C₁₁H₁₁ClO₂
• 分子量: 210.66
• InChiKey: ANDLWWYCCKSGHU-UHFFFAOYSA-N

物化性质

• 沸点：
  323.6±17.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-3-(4-methoxyphenyl)acrylic acid chloride 在 三乙胺 、 1,2-双(二苯基膦)乙烷 、 copper(l) chloride 、 sodium t-butanolate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 48.5h， 生成
  参考文献：
  名称：

  α-烷基 α,β-不饱和酯中的对映和非对映选择性硼共轭加成

  摘要：

  我们在无碱条件下开发了一种铜催化的对映选择性和非对映选择性硼共轭加成到 α-烷基 α,β-不饱和酯中。该方法显示出出色的对映选择性 (87–99% ee) 和中等至良好的转化率 (51–99%)，尽管具有中等的非对映选择性 (1 : 1–17 : 1 dr)。证明了该协议的综合效用。

  DOI：

  10.1039/d2ob01928k
• 作为产物：
  描述：

  3-(4-anisyl)-2-methylacrylic acid 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 甲苯 为溶剂， 生成 2-methyl-3-(4-methoxyphenyl)acrylic acid chloride
  参考文献：
  名称：

  α-烷基 α,β-不饱和酯中的对映和非对映选择性硼共轭加成

  摘要：

  我们在无碱条件下开发了一种铜催化的对映选择性和非对映选择性硼共轭加成到 α-烷基 α,β-不饱和酯中。该方法显示出出色的对映选择性 (87–99% ee) 和中等至良好的转化率 (51–99%)，尽管具有中等的非对映选择性 (1 : 1–17 : 1 dr)。证明了该协议的综合效用。

  DOI：

  10.1039/d2ob01928k

文献信息

• Antimalarials. Synthesis and antimalarial activity of 1-(4-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine and derivatives
  作者：Thomas R. Herrin、Jeanne M. Pauvlik、Evelyn V. Schuber、Adolph O. Geiszler

  DOI：10.1021/jm00246a009

  日期：1975.12

  The preparation and activity against Plasmodium berghei of derivatives of 1-(4-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine are described. Replacement of the cinnamoyl group was accomplished by acylation or alkylation of 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine. Modifications of the 5-phenyl group were prepared either by a sequence of reactions involving mandelic ester-pemoline-piperazine

  描述了1-（4-甲氧基肉桂酰基）-4-（5-苯基-4-氧代-2-恶唑啉-2-基）哌嗪的衍生物的制备及其对伯氏疟原虫的活性。通过1-（5-苯基-4-氧代-2-恶唑啉-2-基）哌嗪的酰化或烷基化来完成肉桂酰基的取代。5-苯基的修饰可以通过一系列涉及扁桃酸酯-二氢萘-哌嗪-哌莫啉的反应或通过5-芳基-2-硫-2,4-恶唑烷二酮与哌嗪或N-取代的哌嗪的反应来制备。以类似的方式，使匹莫林与N-芳基哌嗪，六氢-1H-1,4-二氮杂和2,6-二甲基哌嗪反应，以提供N-芳基哌嗪匹莫林衍生物和哌嗪部分的变异。制备了几种化合物，其中2-恶唑啉-4-酮环被其他杂环取代，以及几种开链类似物。发现有五个化合物（其中三个被5-苯基对位取代）和两个N-芳基哌嗪哌莫林衍生物对柏氏疟原虫有活性。剩余的活性化合物具有肉桂酰基的变化和5-苯基的取代。
• 안료 분산액 및 그것을 사용한 감광성 수지 조성물의 제조 방법
  申请人：TOKYO OHKA KOGYO CO., LTD. 도쿄 오카 고교 가부시키가이샤(519980627398)

  公开号：KR102140676B1

  公开（公告）日：2020-08-04

  [과제]시간 경과 후의 안료의 분산성이 양호하고, 저노광량으로 고밀착성인 미소 패턴을 형성 가능한 감광성 수지 조성물을 시간 경과 후에도 부여할 수 있는 안료 분산액 및 그것을 사용한 감광성 수지 조성물의 제조 방법을 제공한다. [해결 수단]본 발명과 관련된 안료 분산액은 안료와, 용제와, 하기 식(1)로 나타내는 화합물을 함유한다. 식 중, R1 및 R2는 각각 독립적으로 수소 원자 또는 유기기를 나타내지만, 적어도 한쪽은 유기기를 나타낸다. R1 및 R2는 이들이 결합해 환상 구조를 형성하고 있어도 되고, 헤테로 원자의 결합을 포함하고 있어도 된다. R3은 단결합 또는 유기기를 나타낸다. R4~R9는 각각 독립적으로 수소 원자, 유기기 등을 나타내지만, R6 및 R7이 수산기가 되는 경우는 없다. R10은 수소 원자 또는 유기기를 나타낸다.

  The dispersibility of the pigment after a period of time is good, and a photosensitive resin composition capable of forming fine patterns with low exposure doses and high resolution can be provided with a pigment dispersion liquid that can be applied even after a period of time, and a method for manufacturing a photosensitive resin composition using the pigment dispersion liquid. The pigment dispersion liquid related to the present invention contains a pigment, a solvent, and a compound represented by formula (1). In the formula, R1 and R2 independently represent a hydrogen atom or an organic group, but at least one of them represents an organic group. R1 and R2 may form a cyclic structure by bonding, and may include a bond of a hetero atom. R3 represents a single bond or an organic group. R4 to R9 independently represent a hydrogen atom, an organic group, etc., but R6 and R7 do not become hydroxy groups. R10 represents a hydrogen atom or an organic group.
• Multistereocenter-Containing Cyclopentanoids from Ynamides via Oxazolidinone-Controlled Nazarov Cyclization
  作者：Narasimhulu Manchala、Hanson Y. L. Law、Daniel J. Kerr、Rohan Volpe、Romain J. Lepage、Jonathan M. White、Elizabeth H. Krenske、Bernard L. Flynn

  DOI：10.1021/acs.joc.7b00082

  日期：2017.7.7

  multistereocenter-containing cyclopentyl rings is an area of great significance to organic synthesis. In this work, we describe a general protocol for accessing multistereocenter-containing cyclopentanoids from simple N-alkynyloxazolidinones (Ox-ynamides). This protocol involves conversion of Ox-ynamides into Ox-activated divinyl and aryl vinyl ketones that undergo facile Nazarov cyclization with excellent

  实现对含多立体中心的环戊基环的现成对映选择性访问是对有机合成具有重要意义的领域。在这项工作中，我们描述了一个一般协议，用于从简单的访问包含multistereocenter-cyclopentanoids Ñ -alkynyloxazolidinones（牛-ynamides）。该协议涉及的转化牛-ynamides成牛活化经历容易纳扎罗夫环化具有优良的化学-选择性，区域选择性和立体控制二乙烯基和芳基乙烯基酮。在牛年助剂指导反应性和选择性的所有方面，无论是在电环化反应中还是在所生成的羟烯丙基中间体的后续转化中。电环化中的立体诱导是由“偶合扭矩”机制产生的，在该机理中，Ox基团的旋转（由氮孤对与起始的羟烯丙基阳离子的轨道重叠的增加所驱动）与戊二烯基阳离子的末端的旋转相结合，偏向于旋转环闭合的特定方向（扭转选择性）。Ox过渡态的相关孤对稳定作用促进了传统抗性底物的环化作用，扩大了这种不对称Naz
• Negative-type photosensitive resin composition, pattern forming method, cured film, insulating film, color filter, and display device
  申请人：Shiota Dai

  公开号：US09244346B2

  公开（公告）日：2016-01-26

  A negative-type photosensitive resin composition capable of forming a pattern having favorable adhesiveness at a low light exposure; a pattern forming method using the resin composition; a cured film, an insulating film, a color filter formed using resin composition; and a display device provided with the cured film, insulating film, or color filter. The resin composition contains a compound represented by the following formula (1). In the formula, R1 and R2 each independently indicate a hydrogen atom or an organic group, but at least one indicates an organic group. R1 and R2 may be bonded to form a ring structure and may contain a hetero atom bond. R3 indicates a single bond or an organic group. R4 to R9 each independently indicate a hydrogen atom, an organic group, etc., but R6 and R7 are never hydroxyl groups. R10 indicates a hydrogen atom or an organic group.

  一种负型光敏树脂组合物，能够在低光照下形成具有良好粘附性的图案；使用该树脂组合物的图案形成方法；使用该树脂组合物形成的固化膜、绝缘膜、彩色滤光片；以及具有固化膜、绝缘膜或彩色滤光片的显示装置。该树脂组合物包含以下式（1）所表示的化合物。在该式中，R1和R2各自独立表示氢原子或有机基团，但至少一个表示有机基团。R1和R2可以结合形成环状结构，并且可以含有杂原子键。R3表示单键或有机基团。R4到R9各自独立表示氢原子、有机基团等，但R6和R7永远不是羟基。R10表示氢原子或有机基团。
• NOVEL BASE GENERATOR AND ADHESION ENHANCER
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP2725011B1

  公开（公告）日：2021-10-27