9-(4-isopropylphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 9-(4-isopropylphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
• 英文别名: 3,4,6,7-tetrahydro-9-(4-isopropylphenyl)-3,3,6,6-tetramethyl-2H-xanthene-1,8-(5H,9H)-dione；9-(4-isopropylphenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydro-2H-xanthene-1,8-(5H,9H)-dione；9-(4-isopropyl-phenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione；9-(4-Isopropyl-phenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-2H-xanthen-1,8-dion；3,3,6,6-Tetramethyl-9-[4-(propan-2-YL)phenyl]-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-dione；3,3,6,6-tetramethyl-9-(4-propan-2-ylphenyl)-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
• 化学式: C₂₆H₃₂O₃
• mdl: MFCD01001731
• 分子量: 392.538
• InChiKey: DODJWSAUPKSHHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-异丙基苯甲醛 在 乙醇 、 溶剂黄146 作用下， 生成 9-(4-isopropylphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
  参考文献：
  名称：

  Vorlaender, Fresenius Zeitschrift fur Analytische Chemie, 1929, vol. 77, p. 266

  摘要：

  DOI：

文献信息

• Molybdate sulfonic acid: preparation, characterization, and application as an effective and reusable catalyst for octahydroxanthene-1,8-dione synthesis
  作者：Bahador Karami、Zahra Zare、Khalil Eskandari

  DOI：10.2478/s11696-012-0263-y

  日期：2013.1.1

  Molybdate sulfonic acid (MSA) as a highly efficient catalyst was synthesized and employed for the synthesis of octahydroxanthene-1,8-dione derivatives. MSA efficiently catalyzed condensation of a wide range of aryl aldehydes and cyclohexane-1,3-diones to obtain octahydroxanthene-1,8-diones. It was characterized by X-ray fluorescence (XRF), X-ray diffraction (XRD), and FT-IR spectroscopy. This catalyst

  合成了作为高效催化剂的钼酸磺酸（MSA），并用于合成八氢氧杂蒽-1,8-二酮衍生物。MSA有效地催化了各种芳基醛与环己烷-1,3-二酮的缩合反应，从而得到八氢氧杂蒽-1,8-二酮。它的特征在于X射线荧光（XRF），X射线衍射（XRD）和FT-IR光谱。该催化剂可以回收并在其他反应中重复使用几次，以保持其高活性。这种新颖且绿色的方法非常便宜，并具有许多优点，例如产率高，使用可回收且环保的催化剂以及后处理程序简单。
• Zinc oxide nanoparticles: A highly efficient and readily recyclable catalyst for the synthesis of xanthenes
  作者：Javad Safaei-Ghomi、Mohammad Ali Ghasemzadeh

  DOI：10.1016/j.cclet.2012.09.016

  日期：2012.11

  A novel and efficient route for the synthesis of 1,8-dioxooctahydroxanthenes and 14-aryl-14H-dibenzo[a,j]xanthenes is described through one-pot multi-component reaction of dimedone and 2-naphthol with various aryl aldehydes using ZnO nanoparticles under solvent-free conditions. This method provides a novel and improved pathway for the synthesis of xanthenes in the terms of excellent yields, short reaction

  通过使用二甲酮和2-萘酚与各种芳基醛的一锅多组分反应，描述了一种合成1,8-二氧杂八氢氧杂蒽和14-芳基-14 H-二苯并[a，j]黄嘌呤的新颖有效途径。无溶剂条件下的ZnO纳米颗粒。就优异的产率，短的反应时间，可重复使用性和低的催化剂载量而言，该方法提供了一种新颖的和改进的用于合成黄嘌呤的途径。
• A New Access to 1,8-Dioxooctahydroxanthenes Using Yttrium(III) Nitrate Hexahydrate and Tin(II) Chloride Dihydrate as Effective and Reusable Catalysts
  作者：B. Karami、K. Eskandari、Z. Zare、S. Gholipour

  DOI：10.1007/s10593-014-1423-5

  日期：2014.3

  environmentally adapted synthesis of xanthene derivatives by condensation of a wide range of aryl aldehydes and cyclohexane-1,3-diones in the presence of catalytic amounts of yttrium(III) nitrate hexahydrate and tin(II) chloride dihydrate is demonstrated.

  在催化量的硝酸钇（III）六水合物和氯化锡（II）二水合物存在下，通过广泛的芳基醛和环己烷-1,3-二酮的缩合，可以高效，环保地合成x吨衍生物。
• Carbon Nanotube-Supported Butyl 1-Sulfonic Acid Groups as a Novel and Environmentally Compatible Catalyst for the Synthesis of 1,8-Dioxo-octahydroxanthenes
  作者：Parvanak Keveh Boroujeni、Zahra Heidari、Reza Khalifeh

  DOI：10.17344/acsi.2016.2291

  日期：2016.9.15

  novel multiwalled carbon nanotube catalyst with -SO3H functional groups was easily prepared from its starting materials and used as an efficient heterogeneous catalyst for one-pot Knoevenagel condensation, Michael addition, and cyclodehydration of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) with various aromatic aldehydes. Using this method 1,8-dioxo-octahydroxanthenes were obtained in excellent yields

  可以轻松地从其原料轻松制备具有-SO3H官能团的新型多壁碳纳米管催化剂，并用作一锅Knoevenagel缩合，迈克尔加成反应和5,5-二甲基-1,3-环己二酮环脱水的有效多相催化剂（二甲基二酮）和各种芳香醛。使用该方法，在室温下以优异的产率获得了1,8-二氧-八氧杂蒽。本方法在反应温度，反应时间，后处理容易，收率高以及催化剂的回收容易方面是优异的。
• 2,4,6-Trichloro-1,3,5-Triazine-Promoted Synthesis of 1,8-Dioxo-Octahydroxanthenes under Solvent-Free Conditions
  作者：Zhan-Hui Zhang、Xu-Ye Tao

  DOI：10.1071/ch07274

  日期：——

  A practical protocol has been developed for the synthesis of 1,8-dioxo-octahydroxanthenes from aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione under solvent-free conditions in the presence of wet 2,4,6-trichloro-1,3,5-triazine (TCT, cyanuric chloride). The desired products were obtained in high yields with a simple and environmentally benign procedure.

  在无溶剂条件下，在湿 2,4,6- 三氯-1,3,5-三嗪（TCT，氯化氰）的存在下，开发了一种以芳香醛和 5,5-二甲基环己烷-1,3-二酮为原料合成 1,8-二氧代八氢蒽的实用方案。该方法简单、环保，能以高产率获得所需的产品。