8-hydroxy-2-phenyl-hexahydro-7-oxa-2,3a,8b-triaza-cyclopenta[a]cyclopropa[g]naphthalene-1,3,6-trione | 859214-96-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-hydroxy-2-phenyl-hexahydro-7-oxa-2,3a,8b-triaza-cyclopenta[a]cyclopropa[g]naphthalene-1,3,6-trione
• 英文别名: (1R,9S,11S,13S,14S)-14-hydroxy-4-phenyl-12-oxa-2,4,6-triazatetracyclo[7.5.0.02,6.011,13]tetradecane-3,5,10-trione
• CAS: 859214-96-3
• 化学式: C₁₆H₁₅N₃O₅
• 分子量: 329.312
• InChiKey: PYUSHHHGMCBLKG-DKUYFVBVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  93.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-hydroxy-2-phenyl-hexahydro-7-oxa-2,3a,8b-triaza-cyclopenta[a]cyclopropa[g]naphthalene-1,3,6-trione 在 N,N-二甲基丙烯基脲 、 samarium diiodide 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以88%的产率得到(6aS,10R,10aR)-10-Hydroxy-2-phenyl-6,6a,10,10a-tetrahydro-5H-[1,2,4]triazolo[1,2-a]cinnoline-1,3,7-trione
  参考文献：
  名称：

  Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds

  摘要：

  We have accomplished the synthesis of a complex chemical library via elaboration of angular epoxyquinol scaffolds with distinct skeletal frameworks. The key strategy involves highly stereocontrolled [4 + 2] Diels-Alder cycloadditions of chiral, nonracemic epoxyquinol dienes to generate the scaffolds. Further scaffold diversification involves hydrogenation, epimerization, dehydration, and condensation of the carbonyl group with alkoxyamine and carbazate building blocks. Further elaboration of the scaffolds also provided new skeletal frameworks using hydroxyl-directed Diels-Alder cycloaddition and reductive N-N bond cleavage. The overall process afforded 244 highly complex and functionalized compounds. Preliminary biological screening of the library uncovered six compounds which showed significant inhibition of Hsp 72 induction.

  DOI：

  10.1021/jo050956y
• 作为产物：
  描述：

  (1'R,6'S)-4'-bromospiro[1,3-dioxane-2,5'-7-oxabicyclo[4.1.0]hept-3-ene]-2'-one 在 platinum(IV) oxide 、 tris(dibenzylideneacetone)dipalladium (0) 咪唑 、 三苯胂 、 氢氟酸 、 氢气 、 三乙基硼氢化锂 作用下， 以 四氢呋喃 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 甲苯 、 乙腈 为溶剂， 反应 87.0h， 生成 8-hydroxy-2-phenyl-hexahydro-7-oxa-2,3a,8b-triaza-cyclopenta[a]cyclopropa[g]naphthalene-1,3,6-trione
  参考文献：
  名称：

  Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds

  摘要：

  We have accomplished the synthesis of a complex chemical library via elaboration of angular epoxyquinol scaffolds with distinct skeletal frameworks. The key strategy involves highly stereocontrolled [4 + 2] Diels-Alder cycloadditions of chiral, nonracemic epoxyquinol dienes to generate the scaffolds. Further scaffold diversification involves hydrogenation, epimerization, dehydration, and condensation of the carbonyl group with alkoxyamine and carbazate building blocks. Further elaboration of the scaffolds also provided new skeletal frameworks using hydroxyl-directed Diels-Alder cycloaddition and reductive N-N bond cleavage. The overall process afforded 244 highly complex and functionalized compounds. Preliminary biological screening of the library uncovered six compounds which showed significant inhibition of Hsp 72 induction.

  DOI：

  10.1021/jo050956y

文献信息

• Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling
  作者：Shun Su、Dayle E. Acquilano、Jeevanandam Arumugasamy、Aaron B. Beeler、Erin L. Eastwood、Joshua R. Giguere、Ping Lan、Xiaoguang Lei、Geanna K. Min、Adam R. Yeager、Ya Zhou、James S. Panek、John K. Snyder、Scott E. Schaus、John A. Porco

  DOI：10.1021/ol051023r

  日期：2005.6.1

  yThe synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.