(3E,5E,7E,9E)-4,8-Dimethyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-2-trimethylsilanyloxy-deca-3,5,7,9-tetraenenitrile | 292060-57-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3E,5E,7E,9E)-4,8-Dimethyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-2-trimethylsilanyloxy-deca-3,5,7,9-tetraenenitrile
• 英文别名: (3E,5E,7E,9E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)-2-trimethylsilyloxydeca-3,5,7,9-tetraenenitrile
• CAS: 292060-57-2
• 化学式: C₂₄H₃₇NOSi
• 分子量: 383.649
• InChiKey: PNOWACWORYUQQM-XUJYDZMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.26
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3E,5E,7E,9E)-4,8-Dimethyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-2-trimethylsilanyloxy-deca-3,5,7,9-tetraenenitrile 在 四丁基氟化铵 、 水 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 生成 (3E,5E,7E,9E)-1-(4-Hydroxy-phenyl)-4,8-dimethyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-deca-3,5,7,9-tetraen-2-one
  参考文献：
  名称：

  An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide

  摘要：

  The synthesis of a nonhydrolyzable, carbon-linked analogue (4-HBR) of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) using Umpolung methods is described. Preliminary studies of biological activity show 4-HBR is similar to 4-HPR in its actions although a potentially relevant and desirable difference is its reduced suppression of plasma vitamin A levels. These results show that 4-HPR does not have to be hydrolyzed to retinoic acid to produce its chemotherapeutic effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00230-x
• 作为产物：
  描述：

  三甲基氰硅烷 、 视黄醛 在 TEA 作用下， 以 二氯甲烷 为溶剂， 生成 (3E,5E,7E,9E)-4,8-Dimethyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-2-trimethylsilanyloxy-deca-3,5,7,9-tetraenenitrile
  参考文献：
  名称：

  An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide

  摘要：

  The synthesis of a nonhydrolyzable, carbon-linked analogue (4-HBR) of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) using Umpolung methods is described. Preliminary studies of biological activity show 4-HBR is similar to 4-HPR in its actions although a potentially relevant and desirable difference is its reduced suppression of plasma vitamin A levels. These results show that 4-HPR does not have to be hydrolyzed to retinoic acid to produce its chemotherapeutic effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00230-x

文献信息

• An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide
  作者：Kevin L Weiss、Galal Alshafie、Jason S Chapman、Serena M Mershon、Hussein Abou-Issa、Margaret Clagett-Dame、Robert W Curley

  DOI：10.1016/s0960-894x(01)00230-x

  日期：2001.6

  The synthesis of a nonhydrolyzable, carbon-linked analogue (4-HBR) of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) using Umpolung methods is described. Preliminary studies of biological activity show 4-HBR is similar to 4-HPR in its actions although a potentially relevant and desirable difference is its reduced suppression of plasma vitamin A levels. These results show that 4-HPR does not have to be hydrolyzed to retinoic acid to produce its chemotherapeutic effects. (C) 2001 Elsevier Science Ltd. All rights reserved.