2-(dodecyloxy)ethanamine | 15930-70-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(dodecyloxy)ethanamine
• 英文别名: 2-dodecoxyethanamine
• CAS: 15930-70-8
• 化学式: C₁₄H₃₁NO
• 分子量: 229.406
• InChiKey: BNIZTLSGVTUSPW-UHFFFAOYSA-N

物化性质

• 沸点：
  108-110 °C(Press: 14 Torr)
• 密度：
  0.850±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(dodecyloxy)ethanamine 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium acetate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 46.5h， 生成
  参考文献：
  名称：

  具有 1,4-二氮杂双环 [2.2.2] 辛烷的 Dirhodium (II) 桨轮的超分子螺旋组件：对金属超分子螺旋聚合物的螺旋方向偏好和螺旋手性过度放大的显着取代基效应

  摘要：

  我们报告了一系列带有手性苯基或甲基取代的酰胺键合的间三联苯残基与三甘醇单甲醚 (TEG) 或正十二烷基尾的四羧酸二铑 (II) 桨轮的独特配位驱动超分子螺旋组装体。 :1 与 1,4-二氮杂双环[2.2.2]辛烷 (DABCO) 络合。在 CHCl 3 /正己烷(1:1)中与 DABCO 的手性二铑配合物形成单手螺旋配位聚合物，在m处具有可控的螺旋桨手性-三联苯，通过周边相邻酰胺基团之间的分子间氢键网络稳定，主要通过圆二色性 (CD)、振动 CD 和变温 (VT) 吸收支持的协同成核-伸长机制和CD 分析。VT 可见光吸收滴定揭示了聚合度随温度变化的变化。通过X射线衍射和原子力显微镜阐明了柱状超分子螺旋结构。携带大体积苯基和n的均聚物的螺旋方向尽管在侧链具有相同的绝对构型，但-十二烷基取代基与其他手性均聚物的取代基相反。在大多数手性/非手性共聚物中观察到非常强的“军士和士兵”（S&S）效应

  DOI：

  10.1021/jacs.1c12652
• 作为产物：
  描述：

  乙二醇单十二烷基醚 在 咪唑 、 sodium azide 、 四溴化碳 、 水 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 74.0h， 生成 2-(dodecyloxy)ethanamine
  参考文献：
  名称：

  Anchor Dependency for Non-Glycerol Based Cationic Lipofectins: Mixed Bag of Regular and Anomalous Transfection Profiles

  摘要：

  Although detailed structure activity, physicochemical and biophysical investigations in probing the anchor influence in liposomal gene delivery have been reported for glycerol-based transfection lipids, the corresponding investigation for non-glycerol based simple monocationic transfection lipids have not yet been undertaken. Towards this end, herein, we delineate our structure - activity and physicochemical approach in deciphering the anchor dependency in liposomal gene delivery using fifteen new structural analogues (lipids 1 - 15) of recently reported nonglycerol based monocationic transfection lipids. The C-14 analogues in both series 1 (lipids 1 - 6) and series 2 (lipids 7-15) showed maximum efficiency in transfecting COS-1 and CHO cells. However, the C-12 analogue of the ether series (lipid 3) exhibited a seemingly anomalous behavior compared with its transfection efficient C-10 and C-14 analogues (lipids 2 and 4) in being completely inefficient to transfect both COS-1 and CHO cells. The present structure - activity investigation also convincingly demonstrates that enhancement of transfection efficiencies through incorporation of membrane reorganizing unsaturation elements in the hydrophobic anchor of cationic lipids is not universal but cell dependent. The strength of the interaction of lipids 1 - 15 with DNA was assessed by their ability to exclude ethidium bromide bound to the DNA. Cationic lipids with long hydrophobic tails were found, in general, to be efficient in excluding EtBr from DNA. Gel to liquid crystalline transition temperatures of the lipids was measured by fluorescence anisotropy measurement technique. In general (lipid 2 being an exception), transfection efficient lipids were found to have their mid transition temperatures at or below physiological temperatures (37degreesC).

  DOI：

  10.1002/1521-3765(20020215)8:4<900::aid-chem900>3.0.co;2-x

文献信息

• Antibacterial water-soluble cutting fluids resistant to yeast-like fungi
  申请人：YUSHIRO CHEMICAL INDUSTRY CO. LTD.

  公开号：EP0388320A1

  公开（公告）日：1990-09-19

  A bactericide is added to conventional water-soluble cutting fluids to suppress deterioration by micro­organisms. Such fluids are however accompanied by the drawbacks that the bactericide has a narrow antibacterial spectrum and moreover its effects last a short time. It is the object of the present invention to offers water-­soluble cutting fluids which remain resistant to a wide variety of microorganisms for a long time. The present invention therefore offers water-soluble cutting fluids to which has been added a specific amine selected from amines known to date.

  将细菌杀灭剂添加到传统的水溶性切削液中，以抑制微生物的腐败。然而，这种液体伴随着细菌杀灭剂的缺点，即细菌杀灭剂的抗菌谱较窄，而且其效果持续时间较短。本发明的目的是提供一种长时间保持对各种微生物具有抗性的水溶性切削液。因此，本发明提供了一种水溶性切削液，其中添加了一种特定的胺，该胺是从迄今为止已知的胺中选择的。
• AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY
  申请人：WELLSTAT THERAPEUTICS CORPORATION

  公开号：US20150361077A1

  公开（公告）日：2015-12-17

  Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

  本文描述了对炎症、真菌、单细胞寄生微生物和癌症具有活性的胺化合物。这些化合物包含一个单环、双环或三环芳香环，其中含有一个、两个或三个环氮原子。
• Process for preparing 1,3-disubstituted urea
  申请人：SUMIKA FINE CHEMICALS Co., Ltd.

  公开号：EP0846679A2

  公开（公告）日：1998-06-10

  Process for preparing 1,3-disubstituted urea of the formula: wherein R5 is the same as or different from R6, and each of R5 and R6 is independently linear or branched, alkyl of 1-20 carbon atoms, alkenyl group having 2 to 20 carbon atoms or alkynyl group having 2 to 20 carbon atoms, which may have phenoxy, alkoxy of 1-13 carbon atoms, monocycloalkyl of 3-8 carbon atoms, bicycloalkyl of 6-12 carbon atoms, aryl of 6-13 carbon atoms, furyl, pyridyl, or aralkyl of 7-20 carbon atoms, comprising reacting cyclic carbonic acid ester with an amine using alkali metal alkoxide or trialkylamine as base, in safety and high yield.

  制备式 1，3-二取代脲的工艺： 其中 R5 与 R6 相同或不同，R5 和 R6 各自独立地为 1-20 个碳原子的直链或支链烷基、具有 2-20 个碳原子的烯基或具有 2-20 个碳原子的炔基，它们可以具有苯氧基、1-13 个碳原子的烷氧基、3-8 个碳原子的单环烷基、6-12 个碳原子的双环烷基、6-13 个碳原子的芳基、3-8 个碳原子的单环烷基、6-12 个碳原子的双环烷基、6-13 个碳原子的芳基、7-20 个碳原子的呋喃基、吡啶基或芳烷基，包括以碱金属氧化物或三烷基胺为碱，使环状碳酸酯与胺反应，安全且收率高。
• Organopolysiloxane having amide group, and cosmetic material containing same
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2280040A1

  公开（公告）日：2011-02-02

  Provided are an organopolysiloxane that exhibits good dispersion stability within not only organic oil agents but also cosmetic materials that contain a powder, and is able to produce a cosmetic material that exhibits excellent skin affinity, an organopolysiloxane that does not impart a sticky feeling, and exhibits excellent skin affinity and skin adhesion, and a cosmetic material including such an organopolysiloxane. The organopolysiloxane is represented by formula (1) below: in which R1 represents a hydrocarbon group such as an alkyl group, R2 represents a group represented by formula (3) or formula (4) below: in which either R4 represents a specific hydrocarbon group and R5 represents a hydrogen atom or a specific hydrocarbon group, or alternatively, at least one of R4 and R5 represents a hydroxyalkyl group, and A represents a group containing an organosilyl group or organosiloxane residue.

  本发明提供了一种有机聚硅氧烷，该有机聚硅氧烷不仅在有机油剂中，而且在含有粉末的化妆品材料中都具有良好的分散稳定性，并且能够生产出具有优异皮肤亲和性的化妆品材料；一种不会产生粘腻感，并且具有优异皮肤亲和性和皮肤粘附性的有机聚硅氧烷；以及一种包括这种有机聚硅氧烷的化妆品材料。有机聚硅氧烷用下式（1）表示： 其中 R1 代表烃基，如烷基，R2 代表下式（3）或式（4）所代表的基团： 其中 R4 代表一个特定的烃基，R5 代表一个氢原子或一个特定的烃基，或者 R4 和 R5 中至少有一个代表羟烷基，以及 A 代表含有有机硅基团或有机硅氧烷残基的基团。
• ORGANOPOLYSILOXANE HAVING AMIDE GROUP, AND COSMETIC MATERIAL CONTAINING SAME
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2921518A1

  公开（公告）日：2015-09-23

  Provided are an organopolysiloxane that exhibits good dispersion stability within not only organic oil agents but also cosmetic materials that contain a powder, and is able to produce a cosmetic material that exhibits excellent skin affinity, an organopolysiloxane that does not impart a sticky feeling, and exhibits excellent skin affinity and skin adhesion, and a cosmetic material including such an organopolysiloxane. The organopolysiloxane is represented by formula (1) below: in which R1 represents a hydrocarbon group such as an alkyl group, R2 represents a group represented by formula (3) or formula (4) below: in which either R4 represents a specific hydrocarbon group and R5 represents a hydrogen atom or a specific hydrocarbon group, or alternatively, at least one of R4 and R5 represents a hydroxyalkyl group, and A represents a group containing an organosilyl group or organosiloxane residue.

  本发明提供了一种有机聚硅氧烷，该有机聚硅氧烷不仅在有机油剂中，而且在含有粉末的化妆品材料中都具有良好的分散稳定性，并且能够生产出具有优异皮肤亲和性的化妆品材料；一种不会产生粘腻感，并且具有优异皮肤亲和性和皮肤粘附性的有机聚硅氧烷；以及一种包括这种有机聚硅氧烷的化妆品材料。有机聚硅氧烷用下式（1）表示： 其中 R1 代表烃基，如烷基，R2 代表下式（3）或式（4）所代表的基团： 其中 R4 代表特定的烃基，R5 代表氢原子或特定的烃基，或者 R4 和 R5 中至少有一个代表羟烷基，以及 A 代表含有有机硅基团或有机硅氧烷残基的基团。