Dieldrin | 56816-04-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Dieldrin
• 英文别名: (1R,2S,3S,6R,7R,8S,9R,11S)-3,4,5,6,13,13-hexachloro-10-oxapentacyclo[6.3.1.13,6.02,7.09,11]tridec-4-ene
• CAS: 56816-04-7
• 化学式: C₁₂H₈Cl₆O
• 分子量: 380.913
• InChiKey: DFBKLUNHFCTMDC-AUGFTSMQSA-N

物化性质

• 沸点：
  416.2±45.0 °C(Predicted)
• 密度：
  1.84±0.1 g/cm3(Predicted)
• 物理描述：
  Endrin is a white crystalline, odorless solid dissolved in a liquid carrier. It is water emulsifiable. It is toxic by inhalation, skin absorption, and/or ingestion. When heated or burned it may emit toxic hydrogen chloride and phosgene. It is used as a pesticide.
• 颜色/状态：
  WHITE, CRYSTALLINE SOLID
• 气味：
  Odorless
• 熔点：
  201.75 °C
• 闪点：
  80°F (commercial product may contain flammable liquid)
• 溶解度：
  Solubility in g/100 ml solvent at 25 °C: acetone 17, benzene 13.8, carbon tetrachloride 3.3, hexane 7.1, and xylene 18.3
• 蒸汽压力：
  3X10-6 mm Hg @ 20 °C
• 亨利常数：
  8.18e-06 atm-m3/mole
• 稳定性/保质期：
  Endrin is stable in the presence of most alkalis but rearranges to delta-keto endrin in the presence of strong acids, in sunlight and when heated.
• 分解：
  Decomposes above 200 °C.
• 腐蚀性：
  Slightly corrosive to metals
• 气味阈值：
  1.80x10-2 ppm (perfume/flavor grade purity).

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

在动物体内，恩德林被降解，主要是转化为9-酮恩德林和9-羟基恩德林，但也转化为5-羟基恩德林。

IN ANIMALS, ENDRIN IS DEGRADED, LARGELY TO 9-KETOENDRIN & 9-HYDROXYENDRIN, BUT ALSO TO 5-HYDROXYENDRIN.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在6天期间，雄性/大鼠服用豆油中的恩德林，通过粪便排出了66%的剂量...雌性...37%。...粪便分析显示...恩德林...抗-12-羟基恩德林...合成-12-羟基恩德林...3-羟基恩德林...12-酮恩德林...以及Δ-酮恩德林...。

IN A 6-DAY PERIOD, MALES /RATS ADMIN ENDRIN IN ARACHIS OIL/ EXCRETED IN FECES 66% DOSE ... FEMALES ... 37%. ... ANALYSIS /FECES/ REVEALED ... ENDRIN ... ANTI-12-HYDROXYENDRIN ... SYN-12-HYDROXYENDRIN ... 3-HYDROXYENDRIN ... 12-KETOENDRIN ... & DELTA-KETOENDRIN ... .

来源:Hazardous Substances Data Bank (HSDB)

代谢

在大鼠中给予恩德林后，对粪便的分析揭示了一种极性代谢物...反式-4,5-二氢异恩德林-4,5-二醇。另一种极性代谢物尚未被鉴定出来。...雄性大鼠的尿液中包含了恩德林、12-酮恩德林、反-12-羟基恩德林和3-羟基恩德林（比例分别为17:19:2:1）。雌性大鼠的提取物中不包含12-酮恩德林。/建议：12-酮恩德林是最有毒的。/

/IN RATS ADMIN ENDRIN, ANALYSIS OF FECES REVEALED/ A POLAR METABOLITE ... TRANS-4,5-DIHYDROISODRIN-4,5-DIOL. ANOTHER POLAR ... NOT IDENTIFIED. ... URINE FROM MALE RATS CONTAINED ENDRIN, 12-KETOENDRIN, ANTI-12-HYDROXYENDRIN & 3-HYDROXYENDRIN (17:19:2:1, RESPECTIVELY). THE EXTRACTS FROM FEMALE RATS DID NOT CONTAIN 12-KETOENDRIN. /SRP: 12-KETOENDRIN IS THE MOST TOXIC/.

来源:Hazardous Substances Data Bank (HSDB)

代谢

/ENDRIN ADMIN TO RATS IN 6 DAY STUDY/ ... MAJOR METABOLITE IN FEMALE RAT URINE /WAS/ IDENTICAL TO 12-HYDROXYENDRIN O-SULFATE. IN TISSUES /ANALYZED/ 12-KETOENDRIN /WAS/ MAJOR CMPD IN FAT OF MALES; ENDRIN IN FEMALES /BUT/ 12-KETOENDRIN WAS ALSO PRESENT. IN LIVER OF MALES NO ENDRIN /WAS DETECTED/ & 12-KETOENDRIN /WAS/ MAJOR METABOLITE. 六天内给大鼠内给予安得磷的研究中，雌性大鼠尿液中的主要代谢物与12-羟基安得磷O-硫酸盐相同。在分析的组织中，12-酮基安得磷是雄性大鼠脂肪中的主要化合物；雌性大鼠中是安得磷，但12-酮基安得磷也存在于其中。在雄性大鼠的肝脏中没有检测到安得磷，而12-酮基安得磷是主要的代谢物。

/ENDRIN ADMIN TO RATS IN 6 DAY STUDY/ ... MAJOR METABOLITE IN FEMALE RAT URINE /WAS/ IDENTICAL TO 12-HYDROXYENDRIN O-SULFATE. IN TISSUES /ANALYZED/ 12-KETOENDRIN /WAS/ MAJOR CMPD IN FAT OF MALES; ENDRIN IN FEMALES /BUT/ 12-KETOENDRIN WAS ALSO PRESENT. IN LIVER OF MALES NO ENDRIN /WAS DETECTED/ & 12-KETOENDRIN /WAS/ MAJOR METABOLITE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：D组 不可归入人类致癌性类别

Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：D；无法归类为人类致癌性。分类依据：内吸磷的口服给药在两种品系的小鼠的任一性别中均未产生致癌作用。国家癌症研究所（NCI）的生物鉴定提示雄性和雌性大鼠有反应，尽管NCI报告了无证据结论。几个生物鉴定的不充分性使报告的阴性结果的可信度受到质疑。这些不充分性和NCI生物鉴定中的提示性反应不支持E组的分类；相反，D组的分类最能反映这些模棱两可的数据。人类致癌性数据：不充分。动物致癌性数据：不充分。

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Oral administration of endrin did not produce carcinogenic effects in either sex of two strains of mice. An NCI bioassay was suggestive of responses in male and female rats although NCI reported a no evidence conclusion. The inadequacies of the several bioassays call into question the strength of the reported negative findings. These inadequacies and the suggestive responses in the NCI bioassay do not support a Group E classification; rather a Group D classification best reflects the equivocal data. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Inadequate.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

没有关于人类的数据。动物致癌性证据不足。总体评估：第3组：该物质对人类致癌性无法分类。

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A4：不能归类为人类致癌物。

A4: Not classifiable as a human carcinogen.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌物：狄氏剂

IARC Carcinogenic Agent:Endrin

来源:International Agency for Research on Cancer (IARC)

吸收、分配和排泄

恩德林从血浆中清除的速度比狄尔德林快得多，因为胆汁排泄更快。

... ENDRIN IS CLEARED MUCH MORE RAPIDLY FROM PLASMA THAN DIELDRIN BECAUSE OF MORE RAPID BILIARY EXCRETION.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在施用(14)C-恩德林到棉株上部叶面十二周后，回收了33%的施用放射性，其中26%在叶子和叶内，其余在植物的其他部分和土壤中。

TWELVE WK AFTER APPLICATION OF (14)C ENDRIN TO UPPER LEAF SURFACES OF COTTON PLANTS, 33% OF THE APPLIED RADIOACTIVITY WAS RECOVERED, 26% ON & IN THE LEAVES & THE REMAINDER IN THE OTHER PLANT PARTS & SOIL.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

恩德林在牛的体脂中累积，并且以小量排泄在它们的牛奶中。

ENDRIN IS ACCUM IN THE BODY FAT OF COWS & IS EXCRETED IN SMALL AMT IN THEIR MILK.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

与其他有机氯杀虫剂相比，VERY LITTLE ENDRIN（少量的安得灵）在动物体内储存的量非常少。

VERY LITTLE ENDRIN, AS COMPARED TO OTHER ORGANOCHLORINE INSECTICIDES, IS STORED IN ANIMALS.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  boron trifluoride methanol complex 、 Dieldrin 反应 48.0h， 以80%的产率得到
  参考文献：
  名称：

  Astin, Kenneth B.; Fletcher, Adrian V.; Mackenzie, Kenneth, Journal of the Chemical Society. Perkin transactions II, 1982, p. 111 - 124

  摘要：

  DOI：
• 作为产物：
  描述：

  aldrin 在 氢氧化钾 、 碘 、 silver(I) acetate 作用下， 以 1,4-二氧六环 为溶剂， 生成 Dieldrin
  参考文献：
  名称：

  Astin, Kenneth B.; Fletcher, Adrian V.; Mackenzie, Kenneth, Journal of the Chemical Society. Perkin transactions II, 1982, p. 111 - 124

  摘要：

  DOI：

文献信息

• Astin, Kenneth B.; Fletcher, Adrian V.; Mackenzie, Kenneth, Journal of the Chemical Society. Perkin transactions II, 1982, p. 111 - 124
  作者：Astin, Kenneth B.、Fletcher, Adrian V.、Mackenzie, Kenneth、Miller, Andrew S.、Ratcliffe, Norman M.、at al.

  DOI：——

  日期：——