α-cellobiose | 13299-27-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-cellobiose
• 英文别名: cellobiose；maltose；alpha-Cellobiose；(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
• CAS: 13299-27-9
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: GUBGYTABKSRVRQ-MFRLZQSSSA-N

物化性质

• 沸点：
  667.9±55.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)
• 熔点：
  240.0 °C
• 碰撞截面：
  175.7 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  α-cellobiose 在 β-D-glucosidase (sweet almonds) sodium trideuterioacetate 作用下， 以 重水 为溶剂， 反应 1.0h， 生成 D-葡萄糖
  参考文献：
  名称：

  1H-NMR-不饱和酮和β-d-葡萄糖苷双糖。II

  摘要：

  摘要1H NMR光谱法用于测定六种具有D-葡萄糖单元的二糖的酶促水解速率，所述二糖为纤维二糖，拉米纳糖，龙胆二糖，麦芽糖，黑糖和异麦芽糖。用甜杏仁中的β-d-葡糖苷酶水解三种β-d-葡糖苷键联的二糖，并将三种α-d-葡糖苷键合二糖用面包酵母中的麦芽糖酶水解。结果表明，水解速率在很大程度上取决于OH-1的位置。动力学研究直接得出了在低底物浓度下两种端基异构体酶促水解的一级速度常数的商（底物浓

  DOI：

  10.1016/0008-6215(92)80094-h
• 作为产物：
  描述：

  Cellobiose 在 吡啶 、 六甲基二硅氮烷 作用下， 反应 1.0h， 生成 α-cellobiose
  参考文献：
  名称：

  PURIFICATION METHOD AND PRODUCTION METHOD FOR CELLOBIOSE

  摘要：

  本发明提供了一种纯化纤维二糖的方法，包括以下步骤：（A）制备含有纤维二糖的糖溶液；（B）将糖溶液中的纤维二糖占总糖份质量的比例提高至至少50％；（C）结晶纤维二糖；以及一种制备α-型纤维二糖含量高的方法，包括以下步骤：在温度为80至95℃的条件下，将纤维二糖含量至少为总糖份质量的90％的糖溶液干燥。本发明的这些方法允许经济地制备纤维二糖，其纯度和回收率都得到了显着提高，而不需要使用任何复杂的过程。此外，本发明还允许制备高度溶解于水的纤维二糖。

  公开号：

  US20090281305A1

文献信息

• Influence of properties of SAPO's on the one-pot conversion of mono-, di- and poly-saccharides into 5-hydroxymethylfurfural
  作者：Prasenjit Bhaumik、Paresh Laxmikant Dhepe

  DOI：10.1039/c3ra43197e

  日期：——

  Synthesis of 5-hydroxymethylfurfural (5-HMF) from biomass derived mono- and poly-saccharides is gaining importance because of its usefulness in the preparation of important chemicals. In our work, we have synthesized several silicoaluminophosphate (SAPO) catalysts, and have shown that in the absence of any other pH modifying reagents, those are active in converting mono- and poly-saccharides into 5-HMF under biphasic reaction condition at 175 °C. Particularly, SAPO-44 catalyst showed the best activity in the conversion of fructose to yield 78% 5-HMF with 88% selectivity. On the contrary, all other catalysts showed lower yields (H-MOR: 63%, SAPO-5: 32%, 2DCT: 60%). Over SAPO-44, good yields for 5-HMF were observed when glucose (67%), maltose (57%), cellobiose (56%) and starch (68%) were used as substrates. Recycle study carried out with SAPO-44 catalyst in the fructose conversion reaction showed marginal decrease in the activity up to 3rd run and then afterwards constant activity was observed up to 5th run (1st: 78%, 2nd: 71%, 3rd: 66%, 4th: 65%, 5th: 65%). Catalyst characterizations revealed that SAPO catalysts have higher hydrophilic nature than H-MOR (Si/Al = 10) and hence it is postulated that this property may help in achieving better results. Further studies on the catalyst characterizations revealed that SAPO-44 undergoes modifications in its structure. However, ICP-OES data suggests that Al and/or P are not leached out in the solution indicating that change in local environment around elements is possible. The influence of acid amount, type of acid site etc. on the catalytic activity is discussed and found out that strong acid sites are required to boost the 5-HMF yields.

  由生物质衍生的单糖和多糖合成5-羟甲基糠醛（5-HMF）正变得越来越重要，因为它在重要化学品的制备中具有重要价值。在我们的研究中，我们合成了几种硅铝磷酸盐（SAPO）催化剂，并且在没有任何其他pH调节剂的情况下，证明这些催化剂在175 °C的双相反应条件下能有效地将单糖和多糖转化为5-HMF。特别是，SAPO-44催化剂在果糖转化中表现出最佳活性，能够产生78%的5-HMF，并具有88%的选择性。相反，其他所有催化剂的产率均较低（H-MOR: 63%，SAPO-5: 32%，2DCT: 60%）。在SAPO-44催化剂下，当以葡萄糖（67%）、麦芽糖（57%）、细胞二糖（56%）和淀粉（68%）作为底物时，观察到5-HMF的良好产率。在果糖转化反应中进行的SAPO-44催化剂回收实验显示，活性在第3次反应时略有下降，之后在第5次反应中保持恒定（第1次：78%，第2次：71%，第3次：66%，第4次：65%，第5次：65%）。催化剂表征结果表明，SAPO催化剂具有比H-MOR（Si/Al = 10）更高的亲水特性，因此推测这一特性可能有助于获得更好的结果。对催化剂特征的进一步研究表明，SAPO-44的结构发生了变化。然而，ICP-OES数据表明铝和/或磷未从溶液中浸出， indicating 周围元素的局部环境变化是可能的。讨论了酸量、酸位点类型等对催化活性的影响，发现需要强酸位点以提高5-HMF的产率。
• [EN] COMPOUNDS FOR TREATING AND PREVENTING NET ASSOCIATED COMPLICATIONS<br/>[FR] COMPOSÉS POUR TRAITER ET PRÉVENIR DES COMPLICATIONS ASSOCIÉES AU NET
  申请人：UNIV AUSTRALIAN NATIONAL

  公开号：WO2020172698A1

  公开（公告）日：2020-09-03

  The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of NETs in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating NET mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRI)). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of NET mediated ailments. For example, the present invention relates to methods and uses of β-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS.Na), in the therapy of a range of NET mediated ailments in subjects.

  本发明涉及具有高化学稳定性的化合物以及用于抑制受试者中NETs的病理活性的方法。具体而言，本发明涉及具有高化学稳定性的化合物，其用途以及用于抑制或改善NET介导的疾病（例如败血症、全身性免疫反应综合征（SIRS）和缺血再灌注损伤（IRI））的方法。更具体地，本发明涉及一种聚阴离子硫酸化的纤维二糖修饰物，其在其还原端具有一个小的不带电糖苷化链取代基，其中存在取代基导致分子具有高化学稳定性，而不影响分子在治疗NET介导的疾病中的有效性。例如，本发明涉及β-O-甲基纤维二糖硫酸酯（mCBS）或其药学上可接受的盐（例如mCBS.Na）的治疗方法和用途，用于治疗受试者中一系列NET介导的疾病。
• Process for producing aglycon and flavor-improved food containing the aglycon by diglycosidase, and converting agent to be used in the process
  申请人：Tsuruhami Kazutaka

  公开号：US20060216281A1

  公开（公告）日：2006-09-28

  A physiologically active substance of aglycon type, in particular, aglycon isoflavone, can be efficiently produced, without resort to any acid/alkali treatment or fermentation and substantially without changing the physical properties of a material, by treating the material with a sufficient amount of diglycosidase for a sufficient period of time at an appropriate temperature and pH so that a physiologically active substance of glycoside type contained in the material can be converted into the physiologically active substance of aglycon type. Moreover, by using diglycosidase and/or a specific enzyme preparation, the aglycon content in a protein or protein-containing food can be increased and the flavor thereof can be improved.

  一种生理活性物质，特别是糖苷型异黄酮的活性物质，可以通过使用足够量的二糖苷酶在适当的温度和pH下足够长的时间处理原料，而无需采用任何酸碱处理或发酵，并且基本上不改变材料的物理性质，从而高效产生。这样，原料中含有的糖苷型生理活性物质可以转化为糖苷型生理活性物质。此外，通过使用二糖苷酶和/或特定酶制剂，可以增加蛋白质或含蛋白质食品中的糖苷型物质含量，并改善其风味。
• Synthesis of ferrocene-based saccharides and their anti-migration and burning rate catalytic properties
  作者：Zain-ul-Abdin Zain-ul-Abdin、Li Wang、Haojie Yu、Muhammad Saleem、Nasir M. Abbasi、Rizwan Ullah Khan、Raja Summe Ullah、Muhammad Haroon

  DOI：10.1039/c6ra16017d

  日期：——

  In the search for ferrocene-based burning rate catalysts (BRCs) with good burning rate catalytic properties and low migration, we synthesized four ferrocene-based saccharides (S-Fcs). The synthesis of S-Fcs was confirmed by energy-dispersive X-ray (EDX), nuclear magnetic resonance (1H NMR), Fourier transform infra-red (FT-IR) and ultraviolet-visible (UV-Vis) spectroscopy. The electrochemical behavior

  在寻找具有良好燃烧速率催化性能和低迁移率的二茂铁基燃烧速率催化剂（BRC）的过程中，我们合成了四种二茂铁基糖（S-Fcs）。S-Fcs的合成已通过能量色散X射线（EDX），核磁共振（1 H NMR），傅立叶变换红外（FT-IR）和紫外可见（UV-Vis）光谱进行了确认。二茂铁基BRC的电化学行为对研究电子转移燃烧速率催化机理具有重要意义。因此，通过循环伏安法研究了S-Fc的电化学行为。S-Fcs的燃烧速率催化性能用TG和DTG技术测定高氯酸铵（AP）的热分解性能。热分析结果表明，S-Fc具有热稳定性，并且对AP的热分解具有良好的燃烧速率催化作用。在S-FCS也分析了抗迁移的研究与基于二茂铁最常用的燃速催化剂（catocene）和二茂铁的比较。已发现与渐新碳和二茂铁相比，S-Fcs在基于AP的推进剂中显示出优异的抗迁移性能。
• Efficient Catalytic Hydrolysis of Disaccharides by Cerium(IV) Ion at pH 7
  作者：Hitoshi Ishida、Kei-ichi Seri

  DOI：10.1246/cl.1997.379

  日期：1997.4

  CeIV(NH4)2(NO3)6 effectively catalyses hydrolysis of various disaccharides such as sucrose, maltose, lactose, and cellobiose at pH 7.0, and activation energy for sucrose hydrolysis was found to be 14.4 kcal mol−1, which is remarkably smaller than that by 0.18 N HCl, 30 kcal mol−1.

  CeIV(NH4)2(NO3)6在pH 7.0时有效催化蔗糖、麦芽糖、乳糖和纤维二糖等多种二糖的水解，蔗糖水解的活化能为14.4 kcal mol-1，明显小于0.18 N HCl, 30 kcal mol−1。