1,2-dipalmitoyl-3-stearoyl glycerol | 2177-98-2

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,2-dipalmitoyl-3-stearoyl glycerol
• 英文别名: (+/-)-1-Stearo-dipalmitin；Octadecanoic acid, 2,3-bis[(1-oxohexadecyl)oxy]propyl ester；2,3-di(hexadecanoyloxy)propyl octadecanoate
• CAS: 2177-98-2
• 化学式: C₅₃H₁₀₂O₆
• 分子量: 835.389
• InChiKey: DQKMNCLZNGAXNX-UHFFFAOYSA-N

物化性质

• 溶解度：
  二甲基甲酰胺：10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  23
• 重原子数：
  59
• 可旋转键数：
  52
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 palladium on activated charcoal 、 乙酸乙酯 作用下， 生成 1,2-dipalmitoyl-3-stearoyl glycerol
  参考文献：
  名称：

  Chapman, Journal of the Chemical Society, 1957, p. 2716

  摘要：

  DOI：

文献信息

• Selection of surfactant‐modified lipases for interesterification of triglyceride and fatty acid
  作者：Ken‐ichi Mogi、Mitsutoshi Nakajima

  DOI：10.1007/bf02523517

  日期：1996.11

  Interesterification of tripalmitin and stearic acid inn‐hexane was investigated with surfactant‐modified lipases. Various kinds of lipases and surfactants were screened for high interesterification activity of the modified lipases. The modified‐lipase hydrophile‐lipophile balance value and fatty acid group of the surfactants. The modified lipase obtained fromRhizopus japonicus with sorbitan monostearate as surfactant had the highest activity in then‐hexane system. The interesterification activity of the selected modified lipase in molten substrates at 75°C without solvents was the same as that in then‐hexane system at 40°C.

  摘要 利用表面活性剂修饰的脂肪酶研究了三棕榈酸和硬脂酸在己烷中的酯化。筛选了各种类型的脂肪酶和表面活性剂，发现改性脂肪酶具有较高的酯化活性。研究了改性脂肪酶的亲水-亲脂平衡值和表面活性剂的脂肪酸基团。以山梨醇酐单硬脂酸酯为表面活性剂的日本根霉改性脂肪酶在当时的正己烷体系中活性最高。在不使用溶剂的情况下，所选改性脂肪酶在 75°C 的熔融底物中的酯化活性与在 40°C 的正己烷体系中的活性相同。
• Synthesis of triglycerides from 1,3-dibromopropan-2-ol
  作者：Asharam Bhati、Richard J. Hamilton、David A. Steven、Rajender Aneja、Frederick B. Padley

  DOI：10.1039/p29830001553

  日期：——

  1,3-Dibromopropan-2-ol (I) was converted into an acyl derivative (VI) by reaction with an appropriate acyl chloride in the presence of pyridine. The acyl derivative (VI) was subjected to nucleophilic substitution with 3 mol. equiv. tris(decyl)methylammonium carboxylate in refluxing hexane. This led to symmetrical diacid triglycerides in 90–94% yield. Substitution with an equimolar amount of the carboxylate

  通过在吡啶存在下与适当的酰氯反应，将1，3-二溴丙烷-2-醇（I）转化为酰基衍生物（VI）。对酰基衍生物（VI）进行3摩尔亲核取代。当量 在回流己烷中的羧酸三（癸基）甲基铵。这导致对称的二酸甘油三酯收率达到90-94％。用等摩尔量的羧酸取代，主要提供1,2-双酰氧基-3-溴丙烷（VII），可以轻松地将其分离并进一步取代，从而得到约不对称的二酸和三酸三甘油酯。产率96％。脂解显示合成的甘油三酸酯为约。纯度为99％。
• Low concentration aqueous solution of an agent for processing synthetic fibers, method of producing same and method of processing synthetic fibers
  申请人：Takemoto Yushi Kabushiki Kaisha

  公开号：EP1510620A2

  公开（公告）日：2005-03-02

  A low concentration aqueous solution of the agent for processing synthetic fibers is produced by preparing an acidic alkyl phosphate which is solid at room temperature and gradually adding this prepared acidic alkyl phosphate with stirring to an aqueous solution containing potassium hydroxide in an amount to partially neutralize this added acidic alkyl phosphate to obtain a 0.1-10 weight % low concentration aqueous solution of the agent for processing synthetic fibers containing potassium alkyl phosphate.

  制备用于加工合成纤维的药剂的低浓度水溶液的方法是：制备一种在室温下呈固态的酸性烷基磷酸酯，然后在搅拌下将制备好的酸性烷基磷酸酯逐渐加入到含有氢氧化钾的水溶液中，加入的量应能部分中和加入的酸性烷基磷酸酯，以获得含有烷基磷酸酯钾的 0.1-10 重量％的用于加工合成纤维的药剂的低浓度水溶液。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3604269A1

  公开（公告）日：2020-02-05

  The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a target cell using the extracted compounds or a plurality of combinations and promoting the nucleic acid to enter required target sites in vivo of an object.

  本申请涉及从中药中提取多种能够促使核酸递送的化合物或合成化合物，并利用提取的化合物或多种组合促进核酸（如 sRNA）吸收并进入靶细胞，并促进核酸进入物体体内所需的靶位点。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT, AND RELATED PRODUCTS
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3778556A1

  公开（公告）日：2021-02-17

  The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and the entry thereof into a target cell by using the extracted compounds or multiple combinations, and promoting the entry of the nucleic acid into a target site in an object body having such a need. The traditional Chinese medicine is selected from traditional Chinese medicine decoction pieces derived from Rhodiola rosea, Herba Taraxaci, Herba andrographitis, and Flos Lonicerae. The nucleic acid is used for treating diseases, such as heart, spleen, kidney, stomach, lung and/or bowel diseases.

  本发明涉及从中药中提取能够促进核酸递送的多种化合物或合成化合物，利用提取的化合物或多种组合促进sRNA等核酸的吸收及其进入靶细胞，并促进核酸进入有此需要的物体体内的靶位点。所述中药选自红景天、蒲公英、穿心莲、忍冬藤等中药的煎煮片。核酸用于治疗疾病，如心、脾、肾、胃、肺和/或肠疾病。