3-N-乙基氨基乙酰苯胺 | 41378-27-2

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-N-乙基氨基乙酰苯胺
• 中文别名: N-乙基间氨基乙酰苯胺；N-(3-(乙基氨基)苯基)乙酰胺
• 英文名称: N-(3-(ethylamino)phenyl)acetamide
• 英文别名: 3-(N-ethyl)aminoacetanilide；N-ethyl-m-acetamidoaniline；m-acetamido-N-ethylaniline；m-acetylamino-N-ethylaniline；3'-(ethylamino)acetanilide；3-acetamido-N-ethylaniline；Acetamide, N-[3-(ethylamino)phenyl]-；N-[3-(ethylamino)phenyl]acetamide
• CAS: 41378-27-2
• 化学式: C₁₀H₁₄N₂O
• mdl: MFCD00157620
• 分子量: 178.234
• InChiKey: QVXMQKVVQBXQPK-UHFFFAOYSA-N

物化性质

• 沸点：
  384.2±25.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  3-N-乙基氨基乙酰苯胺 以 乙腈 、 正丁醇 、 苯 为溶剂， 反应 66.0h， 生成
  参考文献：
  名称：

  Tuning thiol addition to squaraines by ortho-substitution and the use of serum albumin

  摘要：

  Tuning the reactivity of squaraine dyes toward nucleophilic addition of thiols was investigated. A series of water soluble, aniline-derived squaraines were synthesized with various ortho substitutions to the squaraine ring. As hypothesized, we found that placing moderately electron donating groups in the ortho position conveyed intermediate reactivity to thiols between the essentially non-reactive hydroxyl substituted squaraines and very reactive non-substituted squaraines. Furthermore, serum albumin was tested for its influence on the addition of thiols to the squaraines. The dyes bind in the hydrophobic cavities of the protein, and thus we expected serum albumin to affect the squaraines' reactivity. Rather than a protective effect by the protein, we found a cooperative effect for thiol addition. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2016.11.060
• 作为产物：
  描述：

  碘乙烷 、 间氨基乙酰苯胺 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3-N-乙基氨基乙酰苯胺
  参考文献：
  名称：

  Tuning thiol addition to squaraines by ortho-substitution and the use of serum albumin

  摘要：

  Tuning the reactivity of squaraine dyes toward nucleophilic addition of thiols was investigated. A series of water soluble, aniline-derived squaraines were synthesized with various ortho substitutions to the squaraine ring. As hypothesized, we found that placing moderately electron donating groups in the ortho position conveyed intermediate reactivity to thiols between the essentially non-reactive hydroxyl substituted squaraines and very reactive non-substituted squaraines. Furthermore, serum albumin was tested for its influence on the addition of thiols to the squaraines. The dyes bind in the hydrophobic cavities of the protein, and thus we expected serum albumin to affect the squaraines' reactivity. Rather than a protective effect by the protein, we found a cooperative effect for thiol addition. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2016.11.060

文献信息

• 一种具有N-乙酸酯基结构的染料中间体的合 成方法
  申请人：中南林业科技大学

  公开号：CN109796365B

  公开（公告）日：2021-09-14

  本发明公开了一种具有N‑乙酸酯基结构的染料中间体的合成方法，该方法是将取代苯胺与氯乙酸酯及缚酸剂在80～110℃温度下回流反应0.5～2.0h后，加入催化剂和锌粉，进一步在105～130℃温度下进行分水回流反应1.0～3.0h，即得染料中间体；该染料中间体可直接用于染料合成，该合成方法具有催化反应速度快，产品纯度99％(HPLC)以上，收率在98％以上等优点，该方法特别适用于合成纯度99％以上的含N,N‑二乙酸酯基结构的染料中间体。
• 一种染料中间体的制备方法
  申请人：常熟市筑紫机械有限公司

  公开号：CN106565528A

  公开（公告）日：2017-04-19

  一种染料中间体的制备方法，属于染料中间体制备技术领域。其是以由通式Ⅱ所示的取代苯胺为原料，加入溶剂、氯乙酸甲酯和缚酸剂，在20‑50℃反应3‑18h，然后升温到70℃，加入水，搅拌0.5h，静置分去水层，有机层回收溶剂后，即得到由通式Ⅰ所示的染料中间体。所用原料氯乙酸甲酯的摩尔比小，避免了回收氯乙酸甲酯储存易变质的问题，省去了氯乙酸甲酯蒸馏回收工序，生产效率提高，并且降低了成本；工艺简洁并且反应温和，省去了回流分水过程，有利于工业化生产。
• 含邻苯二甲酰亚胺结构的偶合组分及其制备方法和应用
  申请人：乌海青石化学有限公司

  公开号：CN111303005B

  公开（公告）日：2023-09-08

  本发明公开了一种含邻苯二甲酰亚胺结构的偶合组分及其制备方法和应用，结构式如式(11)‑(13)所示。本发明所制备的含邻苯二甲酰亚胺结构的偶合组分，属于新型的含邻苯二甲酰亚胺的偶合组分，通过连接邻苯二甲酰亚胺苯环上的取代基，从而引入邻苯二甲酰亚胺结构，酰亚胺的氮原子可以连接不同的取代基R1，使染料具有不同的应用性能，表现出优异的水洗色牢度。同时涤纶织物染后可仅使用碱洗工艺，避免了保险粉还原清洗条件下偶氮基被分解产生致癌芳香胺释放到污水，降低了洗涤污水处理负担，具有高环保性能。
• Azo dyes derived from 3-amino-2,1-benzisothiazoles and aromatic amine
  申请人：Eastman Kodak Company

  公开号：US04265812A1

  公开（公告）日：1981-05-05

  Disclosed are mono azo dyes derived from diazotized 3-amino-2,1-benzisothiazoles and certain aniline, 1,2,3,4-tetrahydroquinoline, and benzomorpholine couplers containing sulfoalkyl groups. These dyes impart fast violet to blue shades on polyamide fibers and have the general formula ##STR1## wherein the Coupler is a derivative of an aniline, tetrahydroquinoline, or benzomorpholine derivative wherein a --Z--SO.sub.3 M group is attached to the nitrogen thereof, R may be hydrogen or one to three substituents such as lower alkyl, lower alkoxy, chlorine, bromine, iodine, sulfamoyl, and substituted sulfamoyl, the coupler ring may contain one or more substituents selected from lower alkyl, lower alkoxy, halogen, acylamido, alkylthio or aryloxy, the remaining hydrogen of the aniline coupler nitrogen may be replaced by a substituent such as lower alkyl, substituted lower alkyl, lower alkenyl, aryl, or cycloalkyl, M is Na.sup.+, K.sup.+, NH.sub.4.sup.+, and Z is a linking group such as ethylene.

  本发明涉及一种由重氮化3-氨基-2,1-苯并异噻唑和某些含有磺酰基烷基的苯胺，1,2,3,4-四氢喹啉和苯基吗啡偶合剂衍生的单偶氮染料。这些染料在聚酰胺纤维上呈现出快速的紫色到蓝色色调，并具有一般公式##STR1##其中偶合剂是苯胺、四氢喹啉或苯基吗啡衍生物的衍生物，其中--Z--SO.sub.3 M基团附着在其氮原子上，R可以是氢或一个到三个取代基，如低烷基、低烷氧基、氯、溴、碘、磺酰胺和取代磺酰胺，偶合剂环可以含有一个或多个选自低烷基、低烷氧基、卤素、酰胺基、烷基硫或芳基氧基的取代基，苯胺偶合剂氮的剩余氢可以被取代基所取代，如低烷基、取代低烷基、低烯基、芳基或环烷基，M为Na.sup.+, K.sup.+, NH.sub.4.sup.+, Z为亚乙基等连结基。
• Azo dyes derived from 5-membered heterocyclic amines and aromatic amine
  申请人：Eastman Kodak Company

  公开号：US04282144A1

  公开（公告）日：1981-08-04

  Disclosed are mono azo dyes derived from diazotized 5-membered heterocyclic amines and certain aniline, 1,2,3,4-tetrahydroquinoline, and benzomorpholine couplers containing sulfoalkyl groups. These dyes impart fast violet to blue shades on polyamide fibers and have the general formula D--N.dbd.N--Coupler wherein D is a thiadiazol, isothiazol, pyrazol or thiophene type radical, and the Coupler is an aniline, tetrahydroquinoline, or benzomorpholine derivative wherein a --Z--SO.sub.3 M group is attached to the nitrogen thereof, the coupler ring may contain one or more substituents selected from lower alkyl, lower alkoxy, halogen, acylamido, alkylthio or aryloxy, the remaining hydrogen of the aniline coupler may be replaced by a substituent such as lower alkyl, substituted lower alkyl, lower alkenyl, aryl, or cycloalkyl, M is Na.sup.+, K.sup.+, NH.sub.4.sup.+ or H.sup.+, and Z is a linking group such as ethylene.

  本发明涉及由重氮化5-成员杂环胺和某些含有磺基烷基的苯胺，1,2,3,4-四氢喹啉和苯基吗啡偶合剂衍生的单偶氮染料。这些染料在聚酰胺纤维上呈现出快速的紫色到蓝色色调，其通式为D--N.dbd.N--偶合剂，其中D是噻二唑，异噻唑，吡唑或噻吩类基团，偶合剂是苯胺，四氢喹啉或苯基吗啡衍生物，其中--Z--SO.sub.3 M基团附着在其氮上，偶合剂环上可以含有一个或多个取代基，所选取代基包括较低的烷基，较低的烷氧基，卤素，酰胺基，烷基硫基或芳氧基，苯胺偶合剂的剩余氢原子可以被较低的烷基，取代的较低烷基，较低的烯基，芳基或环烷基等取代基所取代，M是Na.sup.+, K.sup.+, NH.sub.4.sup.+或H.sup.+，Z是如乙烯等的连接基团。