N-(1,3-苯并噻唑-2-基硫基)丙-2-胺 | 10220-34-5

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: N-(1,3-苯并噻唑-2-基硫基)丙-2-胺
• 英文名称: N-isopropyl-2-benzothiazolesulfenamide
• 英文别名: N-i-propyl(2-benzothiazolyl)sulfenamid；Benzthiazolyl-(2)-sulfensaeure-N-isopropyl-amid；N-Isopropyl-benzothiazol-sulfenamid-(2)；N-isopropyl-benzothiazolesulphenamide；S-benzothiazol-2-yl-N-isopropyl-thiohydroxylamine；benzothiazole-2-sulfenic acid isopropylamide；Benzothiazol-2-sulfensaeure-isopropylamid；N-isopropyl-2-benzothiazylsulfenamide；N-isopropylbenzothiazol-2-sulfenamide；N-isopropyl-2-benzothiazolylsulfenamide；2-Benzothiazolesulfenamide, N-(1-methylethyl)-；N-(1,3-benzothiazol-2-ylsulfanyl)propan-2-amine
• CAS: 10220-34-5
• 化学式: C₁₀H₁₂N₂S₂
• 分子量: 224.351
• InChiKey: VIHMZNMSEVOOPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  N-(1,3-苯并噻唑-2-基硫基)丙-2-胺 、 乙酸酐 生成 N-(2-苯并噻唑基硫代)-N-(1-甲基乙基)-2-苯并噻唑次磺酰胺
  参考文献：
  名称：

  Manufacture of sulfenamides

  摘要：

  公开号：

  US02860142A1
• 作为产物：
  描述：

  sodium 2-mercaptobenzothiazole 在 碘 、 potassium iodide 作用下， 生成 N-(1,3-苯并噻唑-2-基硫基)丙-2-胺
  参考文献：
  名称：

  Accelerator for vulcanization of rubber

  摘要：

  公开号：

  US02367827A1

文献信息

• REACTION OF SULFENAMIDES WITH DI-ALKYL AND TRIALKYL PHOSPHITES.AN EFFICIENT SYNTHESIS OF PHOSPHORAMIDATES BY UNUSUAL SUBSTITUTION AT S–N BOND IN (2-BENZOTHIAZOLYL)SULFENAMIDES
  作者：Sigeru Torii、Noboru Sayo、Hideo Tanaka

  DOI：10.1246/cl.1980.695

  日期：1980.6.5

  Regioselective attack of the trivalent phosphorus atom of dialkyl and trialkyl phosphites on either nitrogen or sulfur atom of sulfenamides has been found. The reaction of phenylsulfenamides with dialkyl phosphites yielded phosphorothiolates, whereas the treatment of (2-benzothiazolyl)sulfenamides with dialkyl and trialkyl phosphites gave phosphoramidates in excellent yields.

  发现二烷基和三烷基磷酸酯的三价磷原子对硫氨素中的氮或硫原子进行区域选择性攻击。苯基硫氨素与二烷基磷酸酯反应生成了磷硫酸盐，而（2-苯并噻唑基）硫氨素与二烷基和三烷基磷酸酯反应则优良地生成了磷酰胺。
• Process for the preparation of benzothiazole-2-sulphenamides
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0314663A1

  公开（公告）日：1989-05-03

  In a process for the production of benzothiazole-2-sulphenamides, a 2-mercaptobenzothiazole in the form of a particulate solid or a dispersion of a particulate solid in a liquid carrier is added gradually and concurrently with an aqueous solution of sodium hypochlorite to a solution of an amine in a mixture of water and a water-miscible organic solvent, the amount of amine being not more than 1.25 moles per mole of 2-mercaptobenzothiazole. A feature of the process is that it represents a significant improvement over prior art methods for the production of sulphenamides derived from secondary amines such as dicyclohexylamine and diisopropylamine.

  在生产苯并噻唑-2-磺胺类化合物的过程中，将2-巯基苯并噻唑以颗粒固体或颗粒固体在液体载体中的分散形式逐渐加入并与次氯酸钠的水溶液同时加入到胺类化合物在水和水溶性有机溶剂混合物中的溶液中，胺类化合物的量不超过每摩尔2-巯基苯并噻唑的1.25摩尔。该过程的特点是，它相对于以二环己胺和二异丙胺等二级胺为原料生产磺胺类化合物的先前方法表示了显著的改进。
• Process for the production of sulphenamides
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0029718A1

  公开（公告）日：1981-06-03

  Benzothiazole-2-sulphenamides are prepared by reacting a 1-mercaptobenzothiazole and a primary or secondary amine with oxygen in the presence of a catalyst, for example a metal phthalocyanine, in a reaction medium consisting of (i) a mixture of the amine and water in which the amount of water at the outset of the reaction is from 0.2 to 20% of the weight of the mixture, or (ii) a mixture as defined in (i) diluted with an inert organic solvent miscible with the mixture, in a proportion of up to two parts by weight of the inert organic solvent per part by weight of the mixture.

  苯并噻唑-2-磺酰胺的制备方法是：在催化剂（例如金属酞菁）存在下，使 1-巯基苯并噻唑和伯胺或仲胺与氧在反应介质中反应，反应介质包括(i)胺和水的混合物，其中水的含量在反应开始时为混合物重量的 0.2%至 20%，或(ii)用可与混合物混溶的惰性有机溶剂稀释的(i)定义的混合物，其中水的含量为混合物重量的 2%。2至20%的混合物，或(ii)用与混合物混溶的惰性有机溶剂稀释的(i)中定义的混合物，惰性有机溶剂的比例为每份混合物重量最多两份惰性有机溶剂。
• Organic thiosulphates and thiosulphonates useful as stabilising agents for rubber vulcanisates
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0070143A1

  公开（公告）日：1983-01-19

  Additives for rubber compositions, giving vulcanisates having improved retention of optimum physical properties, are compounds containing two or more groups of the formula -S-S02R linked by an organic bridging group, or polymers containing two or more groups of the formula -S-S02R attached to an organic polymer chain, where R represents (a) a radical OM where M is a monovalent metal, the equivalent of a multivalent metal, a monovalent ion derived by the addition of a proton to a nitrogenous base, or the equivalent of a multivalent ion derived by the addition of two or more protons to a nitrogenous base, or (b) an organic radical selected from aliphatic, cycloaliphatic, aromatic and heterocyclic radicals, and radicals which are combinations of any two or more such radicals.

  用于橡胶组合物的添加剂，使硫化胶能更好地保持最佳物理性能，这些添加剂是含有两个或两个以上由有机桥基连接的式-S-S02R 的化合物，或含有两个或两个以上连接到有机聚合物链上的式-S-S02R 的聚合物，其中 R 代表 (a) 自由基 OM，其中 M 是一价金属、(b) 选自脂肪族、环脂族、芳香族和杂环族的有机自由基，以及由任意两个或多个此类 自由基组合而成的自由基。
• Rubber compositions containing a vulcanization system alterative
  申请人：Monsanto Company

  公开号：EP0104157A1

  公开（公告）日：1984-03-28

  Compositions of vulcanizeable diene rubber, a cross-linking agent, a vulcanization accelerator and a vulcanization system alterative are disclosed, which have improved properties of scorch delay, cure rate and reversion resistance. The alterative is a compound of the formula where R1 and R2 are the same or different radicals selected from alkyl of 1-12 carbon atoms, phenyl, cycloalkyl of 3-8 carbon atoms and alkyaryl and aralkyl of 7-12 carbon atoms, and R3 is selected from the same as R1 and Rz, optionally substituted with one or more halogen, nitro, alkoxy, carboalkoxy, acyl, acyloxy, amido, cyano, thio or sulfonyl substituents.

  本发明公开了可硫化二烯橡胶、一种交联剂、一种硫化促进剂和一种硫化体系改良剂的组合物，这些组合物具有更好的焦烧延迟、硫化速率和抗还原性能。该改良剂是一种式如下的化合物 其中 R1 和 R2 是相同或不同的基团，选自 1-12 个碳原子的烷基、苯基、3-8 个碳原子的环烷基和 7-12 个碳原子的烷芳基和芳烷基，R3 选自与 R1 和 Rz 相同的基团，任选被一个或多个卤素、硝基、烷氧基、羧基、酰基、酰氧基、氨基、氰基、硫基或磺酰基取代。