(4-nitro-phenyl)-(1H-pyrrol-2-yl)-diazene | 136814-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-nitro-phenyl)-(1H-pyrrol-2-yl)-diazene
• 英文别名: (4-nitrophenyl)-(1H-pyrrol-2-yl)diazene
• CAS: 136814-46-5
• 化学式: C₁₀H₈N₄O₂
• 分子量: 216.199
• InChiKey: QHPXGOIMQXXIOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 、 (4-nitro-phenyl)-(1H-pyrrol-2-yl)-diazene 以 乙醇 为溶剂， 反应 6.0h， 以72%的产率得到[Ru(L2)(bpy)2]ClO4
  参考文献：
  名称：

  Ruthenium(II) complexes of pyrrol-azo ligands: cytotoxicity, interaction with calf thymus DNA and bovine serum albumin

  摘要：

  Two ruthenium(II) complexes of newly designed pyrrol-azo ligands(L) and bipyridine(bpy) formulated as [Ru(L)(bpy)(2)]ClO4, where HL1=(4-chloro-phenyl)-(1H-pyrrol-2-yl)-diazene (1) complex 1 and HL2=(4-nitro-phenyl)-(1H-pyrrol-2-yl)-diazene for 2, were isolated in pure form. The complexes were characterized by physicochemical and spectroscopic methods. The electrochemical behavior of the complexes showed the Ru(III)/Ru(II) couple at different potentials with quasi-reversible voltammograms. The study of cytotoxicity effects of 1 and 2 on human breast cancer cells (MCF 7, MDA-MB 231) and cervical cancer cell (HeLa) taking Cisplatin as a positive reference showed that 1 exhibited higher cytotoxicity against cancer cell lines than 2, but less activity than Cisplatin. The interaction of 1 with calf thymus DNA (CT-DNA) using absorption, emission spectral studies, viscosity-measurement, and electrochemical techniques has been used to determine the binding constant K-b and the linear Stern-Volmer quenching constant K-SV. The results indicate that 1 strongly interacts with CT-DNA in groove binding mode. The interaction of bovine serum albumin (BSA) with 1 was also investigated with the help of spectroscopic tools. Absorption spectroscopy proved the formation of a BSA-[Ru(L-1)(bpy)(2)]ClO4 complex.

  DOI：

  10.1080/00958972.2013.814048
• 作为产物：
  描述：

  吡咯 、 4-硝基苯胺 在 盐酸 、 sodium nitrite 、 sodium carbonate 作用下， 以 水 为溶剂， 以80%的产率得到(4-nitro-phenyl)-(1H-pyrrol-2-yl)-diazene
  参考文献：
  名称：

  Ruthenium(II) complexes of pyrrol-azo ligands: cytotoxicity, interaction with calf thymus DNA and bovine serum albumin

  摘要：

  Two ruthenium(II) complexes of newly designed pyrrol-azo ligands(L) and bipyridine(bpy) formulated as [Ru(L)(bpy)(2)]ClO4, where HL1=(4-chloro-phenyl)-(1H-pyrrol-2-yl)-diazene (1) complex 1 and HL2=(4-nitro-phenyl)-(1H-pyrrol-2-yl)-diazene for 2, were isolated in pure form. The complexes were characterized by physicochemical and spectroscopic methods. The electrochemical behavior of the complexes showed the Ru(III)/Ru(II) couple at different potentials with quasi-reversible voltammograms. The study of cytotoxicity effects of 1 and 2 on human breast cancer cells (MCF 7, MDA-MB 231) and cervical cancer cell (HeLa) taking Cisplatin as a positive reference showed that 1 exhibited higher cytotoxicity against cancer cell lines than 2, but less activity than Cisplatin. The interaction of 1 with calf thymus DNA (CT-DNA) using absorption, emission spectral studies, viscosity-measurement, and electrochemical techniques has been used to determine the binding constant K-b and the linear Stern-Volmer quenching constant K-SV. The results indicate that 1 strongly interacts with CT-DNA in groove binding mode. The interaction of bovine serum albumin (BSA) with 1 was also investigated with the help of spectroscopic tools. Absorption spectroscopy proved the formation of a BSA-[Ru(L-1)(bpy)(2)]ClO4 complex.

  DOI：

  10.1080/00958972.2013.814048