N,N-二甲基甘氨酰胺 | 1857-19-8

• 物质功能分类: 有机原料 - 氨基化合物 - 酰胺类化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N,N-二甲基甘氨酰胺
• 中文别名: N~1~,N~1~-二甲基甘氨酸酰胺1HCL；2-胺基-N,N-二甲基乙酰胺；N,N-二甲基氨基甘氨酸；2-氨基-N,N-二甲基乙酰胺
• 英文名称: N',N'-dimethylglycinamide
• 英文别名: 2-amino-N,N-dimethylacetamide；glycine dimethylamide
• CAS: 1857-19-8
• 化学式: C₄H₁₀N₂O
• mdl: MFCD06655264
• 分子量: 102.136
• InChiKey: KNVRBEGQERGQRP-UHFFFAOYSA-N

物化性质

• 沸点：
  60 °C(Press: 0.8 Torr)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  8
• 海关编码：
  2924199090
• 危险类别：
  8
• 包装等级：
  III
• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340+P312,P305+P351+P338+P310,P332+P313,P362,P403+P233,P405,P501
• 危险品运输编号：
  2735
• 危险性描述：
  H314
• 储存条件：
  应存放在2-8°C的环境中，避免光照，并保持在惰性气体中。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Amino-n,n-dimethylacetamide
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H314: Causes severe skin burns and eye damage
H318: Causes serious eye damage
P280: Wear protective gloves/protective clothing/eye protection/face protection
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P309: IF exposed or you feel unwell:
P310: Immediately call a POISON CENTER or doctor/physician

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Amino-n,n-dimethylacetamide
CAS number: 1857-19-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
No data
Boiling point:
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C4H10N2O
Molecular weight: 102.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
UN Number: UN2735 Class: 8 Packing group: III
Proper shipping name: AMINES, LIQUID, CORROSIVE, N.O.S. OR POLYAMINES, LIQUID, CORROSIVE, N.O.S.
(2-Amino-n,n-dimethylacetamide)

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N,N-二甲基甘氨酰胺 生成 N-[2-(Dimethylamino)-2-oxoethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide
  参考文献：
  名称：

  HIV INTEGRASE INHIBITORS

  摘要：

  本发明具有作为HIV整合酶抑制剂的化合物，因此在抑制HIV复制、预防及/或治疗HIV感染以及治疗艾滋病及/或艾滋病相关综合症方面具有用途。

  公开号：

  US20150225399A1
• 作为产物：
  描述：

  N-[2-(二甲氨基)-2-氧乙基]-氨基甲酸-1,1-二甲基乙酯 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 N,N-二甲基甘氨酰胺
  参考文献：
  名称：

  Highly Selective and Sensitive Detection of Biogenic Defense Phytohormone Salicylic Acid in Living Cells and Plants Using a Novel and Viable Rhodamine-Functionalized Fluorescent Probe

  摘要：

  Detecting plant-derived signal molecules using fluorescent probes is a key topic and a huge challenge for scientists. Salicylic acid (SA), a vital plant-derived defense hormone, can activate global transcriptional reprogramming to systemically express a network of prominent pathogenesis-related proteins against invasive microorganisms. This strategy is called systemic acquired resistance (SAR). Therefore, monitoring the dynamic fluctuations of SA in subcellular microenvironments can advance our understanding of different physiological and pathological functions during the SA-induced SAR mechanism, thus benefiting the discovery and development of novel immune activators that contribute to crop protection. Here, detection of signaling molecule SA in plant callus tissues was first reported and conducted by a simple non-fluorescent rhodamine-tagged architecture bearing a flexible 2-amino-N,N-dimethylacetamide pattern. This study can markedly advance and promote the usage of fluorescent SA probes for distinguishing SA in the plant kingdom.

  DOI：

  10.1021/acs.jafc.9b06771

文献信息

• Chiral Aldehyde Catalysis for the Catalytic Asymmetric Activation of Glycine Esters
  作者：Wei Wen、Lei Chen、Ming-Jing Luo、Yan Zhang、Ying-Chun Chen、Qin Ouyang、Qi-Xiang Guo

  DOI：10.1021/jacs.8b06676

  日期：2018.8.1

  Chiral aldehyde catalysis is uniquely suitable for the direct asymmetric α-functionalization of N-unprotected amino acids, because aldehydes can reversibly form imines. However, there have been few successful reports of these transformations. In fact, only chiral aldehyde catalyzed aldol reactions of amino acids and alkylation of 2-amino malonates have been reported with good chiral induction. Here

  手性醛催化特别适用于 N-未保护氨基酸的直接不对称 α-官能化，因为醛可以可逆地形成亚胺。然而，关于这些转变的成功报道很少。事实上，只有手性醛催化氨基酸的羟醛反应和 2-氨基丙二酸酯的烷基化具有良好的手性诱导作用。在这里，我们报告了一种基于烯醇中间体表面控制的新型手性醛催化剂。由此产生的手性醛是第一种有效的非吡哆醛依赖性催化剂，可以促进 N-未保护甘氨酸酯的直接不对称 α-官能化。通过密度泛函理论计算研究了可能的过渡态和质子转移过程。
• Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
  申请人：——

  公开号：US20030055071A1

  公开（公告）日：2003-03-20

  Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

  描述了包括某些喹啉羧酰胺和萘啉羧酰胺衍生物在内的氮杂萘基羧酰胺衍生物。这些化合物是HIV整合酶的抑制剂和HIV复制的抑制剂，可用于预防或治疗HIV感染和治疗艾滋病，作为化合物或药学上可接受的盐，或作为药物组合物中的成分，可选择与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。还描述了预防、治疗或延缓艾滋病发作的方法，以及预防或治疗HIV感染的方法。
• PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES
  申请人：Ajinomoto Co., Inc.

  公开号：US20160046592A1

  公开（公告）日：2016-02-18

  An object is to provide a novel compound which has a glycogen synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. Provided is a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: wherein Ar 1 represents any one of the following rings (II) and (III): wherein R 2 represents an alkyl group, and R 3 represents a hydrogen atom or an alkyl group, and R 1 represents any one of the following substituents (IV) and (V):

  提供一种新型化合物，具有糖原合成酶激活能力，但对PPAR受体的激活程度较低且具有高度安全性。提供的化合物由以下一般式(I)或其药学上可接受的盐表示：其中Ar1代表以下环之一(II)和(III)：其中R2代表烷基基团，R3代表氢原子或烷基基团，R1代表以下取代基之一(IV)和(V)：
• Cu-catalyzed asymmetric [3+2] cycloaddition of α-iminoamides with activated olefins
  作者：María González-Esguevillas、Javier Adrio、Juan C. Carretero

  DOI：10.1039/c2cc17149j

  日期：——

  A variety of 2-amido pyrrolidines, including Weinreb-type amides, have been prepared with very high exo diastereoselectivity and enantioselectivitiy in the reaction of alpha-iminoamides with activated alkenes catalyzed by Cu(I)-Segphos ligands.

  在α-亚氨基酰胺与Cu（I）-Segphos配体催化的活化烯烃的反应中，制备了多种具有很高的外非对映选择性和对映选择性的2-酰胺基吡咯烷，包括Weinreb型酰胺。
• New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists
  作者：Christopher M. Yea、Christine E. Allan、Doreen M. Ashworth、James Barnett、Andy J. Baxter、Janice D. Broadbridge、Richard J. Franklin、Sally L. Hampton、Peter Hudson、John A. Horton、Paul D. Jenkins、Andy M. Penson、Gary R. W. Pitt、Pierre Rivière、Peter A. Robson、David P. Rooker、Graeme Semple、Andy Sheppard、Robert M. Haigh、Michael B. Roe

  DOI：10.1021/jm8008162

  日期：2008.12.25

  proven an effective drug for diseases where a reduction of urine output is desired. However, its peptidic nature limits its bioavailability. We report herein the discovery of potent, nonpeptidic, benzylurea derived agonists of the vasopressin V2 receptor. We describe substitutions on the benzyl group to give improvements in potency and subsequent modifications to the urea end group to provide improvements

  加压素（AVP）是一种激素，可通过激活肾脏中的V2受体来刺激水渗透性的增加。AVP的去氨加压素类似物已被证明可有效治疗需要减少尿量的疾病。但是，其肽性质限制了其生物利用度。我们在此报告了加压素V2受体有效，非肽类，苄脲衍生的激动剂的发现。我们描述了苄基上的取代，以提高效力，随后对尿素端基进行了修饰，从而在利尿大鼠模型中提高了溶解度并提高了口服功效。首次报道了铅化合物20e（VA106483），已被选择用于临床开发。