(1S,4R)-(+)-1-methyl-3,3-dimethyl-2-methylenebicyclo[2.2.1]heptane | 96093-10-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S,4R)-(+)-1-methyl-3,3-dimethyl-2-methylenebicyclo[2.2.1]heptane
• 英文别名: (+)-1-methyl-3,3-dimethyl-2-methylenebicyclo[2.2.1]heptane；(1S,4R)-1,3,3-trimethyl-2-methylene-norbornane；2-Methylcamphene；homofenchene；(+)-methylenefenchone；(1S)-1,3,3-trimethyl-2-methylene-norbornane；(1S,4R)-1,3,3-trimethyl-2-methylidenebicyclo[2.2.1]heptane
• CAS: 96093-10-6
• 化学式: C₁₁H₁₈
• 分子量: 150.264
• InChiKey: IWWRARFUNWPJJJ-KOLCDFICSA-N

物化性质

• 沸点：
  167.9±7.0 °C(Predicted)
• 密度：
  0.88±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (1S,4R)-(+)-1-methyl-3,3-dimethyl-2-methylenebicyclo[2.2.1]heptane 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 镍 potassium fluoride 、 重铬酸吡啶 、 氢气 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 异丙醇 、 苯 为溶剂， 反应 87.0h， 生成
  参考文献：
  名称：

  The sweetness and stereochemistry of l-aspartyl-fenchylaminoalcohol derivatives

  摘要：

  Four fenchylaminoalcohols were derived from (+)-fenchone in five steps. They were resolved with (+)- and (-)-tartaric acid, then condensed with N-carbobenzoxy-L-aspartic acid beta-benzylester followed by hydrogenolysis to give four L-aspartyl-fenchylaminoalcohols. By the evaluation of their taste, only (2R,3R)-aminoalcohol showed potent sweetness.

  DOI：

  10.1016/0040-4039(94)85033-x
• 作为产物：
  描述：

  (1R,2S,4R)-2-(hydroxymethyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 (1S,4R)-(+)-1-methyl-3,3-dimethyl-2-methylenebicyclo[2.2.1]heptane
  参考文献：
  名称：

  （+）-（3,3-二甲基-2-亚甲基降冰片-1-基）甲磺酸甲酯的制备和应用：新型多功能手性芬奇酮类似物

  摘要：

  （+）-（3,3-二甲基-2-亚甲基降冰片烷-1-基）甲磺酸甲酯（9）的制备是通过（-）-2-亚甲基冰片烷的二羟基化和甲磺酰化两个步骤进行的。水解和还原9分别得到品醇（2）和亚甲基f酮（21）。9的氧化提供了一个新的类似氧杂三环化合物的类似物（23）。用NBS处理9会导致Wagner-Meerwein重排，从而生成溴化的亚甲基冰片烷衍生物（25和26），它们也是新化合物。

  DOI：

  10.1016/j.tet.2003.08.066

文献信息

• [EN] NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS<br/>[FR] ANTAGONISTES NON COMPÉTITIFS DU RÉCEPTEUR NICOTINIQUE
  申请人：TARGACEPT INC

  公开号：WO2014004417A1

  公开（公告）日：2014-01-03

  The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for their use, and their pharmaceutical compositions.

  本发明涉及调节尼古丁受体的化合物，作为非竞争性拮抗剂，其合成方法，使用方法以及它们的药物组合物。
• Modelling and control of a seven level NPC voltage source inverter. Application to high power induction machine drive
  作者：H. Gheraia、E. M. Berkouk、G. Manesse

  DOI：10.1051/epjap:2001172

  日期：2001.8

  In this paper, we study a new kind of continuous-alternating converters: a seven-level neutral point clamping (NPC) voltage source inverter (VSI). We propose this inverter for applications in high voltage and high power fields. In the first part, we develop the knowledge and the control models of this inverter using the connections functions of the semi-conductors. After that, we present two pulse width modulation (PWM) algorithms to control this converter using its control model. We propose these algorithms for digital implementation. This multilevel inverter is associated to the induction machine. The performances obtained are full of promise to use it in the high voltage and high power fields of electrical traction.

  在本文中，我们研究了一种新型的连续交替变换器：七级中性点钳位（NPC）电压源逆变器（VSI）。我们提出这种逆变器用于高电压和高功率领域的应用。在第一部分中，我们利用半导体的连接函数发展了该逆变器的知识和控制模型。之后，我们提出了两种脉宽调制（PWM）算法，以基于其控制模型来控制该变换器。我们建议将这些算法用于数字实现。该多级逆变器与感应电机相结合。所获得的性能在高电压和高功率的电气牵引领域中展示了良好的应用前景。
• Microwave dielectric relaxation of ferroelectric PLZT ceramics in the range of 300-900 K
  作者：A. Mouhsen、M. E. Achour、J. L. Miane、J. Ravez

  DOI：10.1051/epjap:2001171

  日期：2001.8

  Dielectric response of PLZT(x/65/35) ceramics (with x = 0, 2, 4, 5) was studied using radio frequency and microwave techniques in the temperature range 300−900 K and with a frequency range of 10^{2 Hz-3 × 109 Hz. Dielectric relaxation appears around 1 × 109 Hz at room temperature. The relaxation frequency softens at T_{c and the dielectric relaxation exists in both paraelectric and ferroelectric phases and depends on x the lanthanum concentration. A model of correlation chains gives some keys for understanding the frequency behaviour of such materials.}}

  PLZT(x/65/35) 陶瓷（其中 x = 0, 2, 4, 5）的介电响应在温度范围 300−900 K 及频率范围 10² Hz-3 × 10⁹ Hz 下采用射频和微波技术进行研究。介电松弛在室温下出现在 1 × 10⁹ Hz 附近。在 T_c 处，松弛频率出现软化，介电松弛同时存在于顺电和铁电相中，并依赖于铈浓度 x。相关链模型为理解此类材料的频率行为提供了一些线索。
• Activation of methylenetriphenylphosphorane by reaction with -butyl- or -butyllithium
  作者：E.J. Corey、Jahyo Kang、Keith Kyler

  DOI：10.1016/s0040-4039(00)89146-7

  日期：1985.1

  Experimental details are provided to support a previous report that α-methylenetriphenylphosphorane () may be activated for reaction with unreactive substrates such as epoxides and hindered ketones by α-metallation to .

  提供了实验细节以支持先前的报道，即α-亚甲基三苯基膦烷（）可以通过α-金属化为，与非反应性底物（例如环氧化物和受阻酮）反应而活化。
• Gas-phase thermolyses. Part 3. Gas-phase thermolysis of silylated thionocarboxylic acid derivatives: a route to thioketens?
  作者：Lars Carlsen、Helge Egsgaard、Ernst Schaumann、Herbert Mrotzek、Wolf-R�diger Klein

  DOI：10.1039/p29800001557

  日期：——

  The unimolecular gas-phase thermolytic decomposition of three silylated thionocarboxylic acid derivatives (2b), (3), and (8) have been studied by the flash vacuum thermolysis–field ionization mass spectrometry technique in the temperature range from 783 to 1 404 K in order to elucidate its possible applicability as a route to thioketens. Only very minor amounts of the expected thioketens were found

  通过闪蒸真空热解-场电离质谱技术在783至1404 K为了阐明其可能的用途，作为通往硫酮的途径。仅发现了极少量的预期硫酮，而相应的酮却是主要产物。讨论了keten形成的可能机制。