15-bromo-pentadecanal | 345909-09-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 15-bromo-pentadecanal
• 英文别名: 15-bromopentadecanal
• CAS: 345909-09-3
• 化学式: C₁₅H₂₉BrO
• 分子量: 305.299
• InChiKey: NTZITTZMPZRMBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  17
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  15-bromo-pentadecanal 在 palladium on activated charcoal lithium aluminium tetrahydride 、 正丁基锂 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 、 乙腈 为溶剂， -78.0~20.0 ℃ 、101.33 kPa 条件下， 生成 18-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-3-yl]-octadecan-1-ol
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616
• 作为产物：
  描述：

  环十五内酯 在 硼烷四氢呋喃络合物 、 PCC on alumina 、 硫酸 、 氢溴酸 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 120.0h， 生成 15-bromo-pentadecanal
  参考文献：
  名称：

  [EN] DIENE GEMINI POLYMERIZABLE SURFACTANTS WITH MIXED CIS AND TRANS ISOMERS THAT FORM BICONTINUOUS CUBIC PHASES
  [FR] TENSIOACTIFS POLYMÉRISABLES PAR DIÈNES GÉMINI AVEC ISOMÈRES CIS ET TRANS MÉLANGÉS QUI FORMENT DES PHASES CUBIQUES BICONTINUES

  摘要：

  一种基于尾基具有混合异构烯烃的可聚合的双子表面活性剂。这些双子表面活性剂可以具有咪唑头基和尾基，尾基中的Έ"和"Z"异构体几乎等量。这些化合物是可以通过自组装形成双连续立方相的亲液晶液晶体。

  公开号：

  WO2020014263A1

文献信息

• Polymerization of a Phosphonium Diene Amphiphile in the Regular Hexagonal Phase with Retention of Mesostructure
  作者：Bradford A. Pindzola、Benjamin P. Hoag、Douglas L. Gin

  DOI：10.1021/ja0058583

  日期：2001.5.1
• METHOD AND MEMBRANE FOR NANOPOROUS, BICONTINUOUS CUBIC LYOTROPIC LIQUID CRYSTAL POLYMER MEMBRANES THAT ENABLE FACILE FILM PROCESSING AND PORE SIZE CONTROL
  申请人：The Regents of the University of Colorado, a body corporate

  公开号：EP2734289A2

  公开（公告）日：2014-05-28
• Method and Membrane for Nanoporous, Bicontinuous Cubic Lyotropic Liquid Crystal Polymer Membranes that Enable Facile Film Processing and Pore Size Control
  申请人：Gin Douglas L.

  公开号：US20140154499A1

  公开（公告）日：2014-06-05

  A method of forming a nanoporous membrane includes preparing a solution of a gemini Imidazolium Lyotropic Liquid Crystal (LLC) monomer, a polar low-volatility organic solvent, and a radical photo-initiator in a volatile organic solvent; solvent-casting the solution onto a porous material, evaporating the volatile organic solvent; heating such that the gemini imidazolium monomer forms a Q-phase material and photopolymerizing the imidazolium monomer by exposing the radical photo-initiator to UV light; and exchanging the polar low-volatility organic solvent. Also disclosed is a membrane composed of polymerized gemini imidazolium LLC monomers, and a thin-film composite membrane having the Q-phase material supported on a porous supporting membrane.
• DIENE GEMINI POLYMERIZABLE SURFACTANTS WITH MIXED CIS AND TRANS ISOMERS THAT FORM BICONTINUOUS CUBIC PHASES
  申请人：TDA Research, Inc

  公开号：US20210300876A1

  公开（公告）日：2021-09-30

  A polymerizable Gemini surfactant based on tail groups with mixed isomer dienes. The Gemini surfactants may be produced having imidazolium head groups and diene tail groups with a near-equal abundance of the “E” and “Z” isomers. These compounds are lyotropic liquid crystals that can form bicontinuous cubic phases by self-assembly.
• [EN] METHOD AND MEMBRANE FOR NANOPOROUS, BICONTINUOUS CUBIC LYOTROPIC LIQUID CRYSTAL POLYMER MEMBRANES THAT ENABLE FACILE FILM PROCESSING AND PORE SIZE CONTROL<br/>[FR] PROCÉDÉ ET MEMBRANE POUR MEMBRANES NANOPOREUSES À BASE D'UN POLYMÈRE À CRISTAUX LIQUIDES LYOTROPES EN PHASE CUBIQUE BICONTINUE QUI FACILITENT LE TRAITEMENT DES FILMS ET LE CONTRÔLE DE LA TAILLE DE PORES
  申请人：UNIV COLORADO

  公开号：WO2013058851A2

  公开（公告）日：2013-04-25

  A method of forming a nanoporous membrane includes preparing a solution of a gemini Imidazolium Lyotropic Liquid Crystal (LLC) monomer, a polar low-volatility organic solvent, and a radical photo-initiator in a volatile organic solvent; solvent-casting the solution onto a porous material, evaporating the volatile organic solvent; heating such that the gemini imidazolium monomer forms a Q-phase material and photopolymerizing the imidazolium monomer by exposing the radical photo-initiator to UV light; and exchanging the polar low-volatility organic solvent. Also disclosed is a membrane composed of polymerized gemini imidazolium LLC monomers, and a thin- film composite membrane having the Q-phase material supported on a porous supporting membrane.