Under certain conditions, fluorocarbon vapors may decompose on contact with flames or hot surfaces, creating the potential hazard of inhalation of toxic decomposition products. /Fluorocarbons/
粘度：
0.72 cP at 25 °C (liq)
汽化热：
7.166 kcal/mol at boiling point
表面张力：
18 dyne cm at 25 °C
折光率：
Index of refraction = 1.361 at 25 °C
保留指数：
541
稳定性/保质期：
Stable.
计算性质
辛醇/水分配系数(LogP)：
3.3
重原子数：
8
可旋转键数：
1
环数：
0.0
sp3杂化的碳原子比例：
1.0
拓扑面积：
0
氢给体数：
0
氢受体数：
4
ADMET
毒理性
副作用
神经毒素 - 急性溶剂综合征
Neurotoxin - Acute solvent syndrome
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
毒理性
毒性数据
大鼠LC50 = 584,000毫克/立方米/4小时
LC50 (rat) = 584,000 mg/m3/4h
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
If inhalation occurs, epinephrine or other sympathomimetic amines and adrenergic activators should not be admin since they will further sensitize heart to development of arrhythmias. /fluorocarbons/
Inhalation by mice of dibromotetrafluoroethane (0.63-1.0%) for 5 hr daily for 3 or 4 days reduced hexobarbital (120 mg/kg) sleeping time and zoxazolamine (100 mg/kg) paralysis time 2 fold. Hepatic microsomal hexobarbital oxidase and zoxazolamide hydroxylase activities were increased but DFK 525-A in the assay inhibited the increase in hepatic microsomal hexobarbital oxidase.
The combination of cyanide, hydrobromic acid and freon-114B2 in air due to pyrolytic degradation of freon used in fire extinguishers may have a toxic effect on humans exposed to fumes. The combination of freon-114B2 (inhaled) and cyanide, administered ip as sodium cyanide, had an additive toxic effect on mice. Freon-114B2, a narcotic, inhibited tissue respiration at the flavoprotein and cytochrome stage; the cyanide affected the oxidoreductase and, in part, the cytochrome/oxidase systems. A combination of sodium cyanide and hydrobromic acid administered ip to rats had an antagonistic effect. Hydrobromic acid, a nonspecific irritant, acted as a stress factor and induced body resistance to the combined effect. LD84 (LD for 84% of subjects), LD50 and LD16 (LD for 16% of subjects) values for sodium cyanide and hydrobromic acid were also determined.
... Main factor affecting fate of fluorocarbons is body fat, where they are concentrated and slowly released into blood at concentrations that should not cause any risk of cardiac sensitization. /fluorocarbons/
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
氟碳化合物在大脑、肝脏和肺部的积聚量显著高于血液水平，表明氟碳化合物在组织中的分布类似于氯仿。
There is a significant accumulation of fluorocarbons in brain, liver and lung compared to blood levels, signifying a tissue distribution of fluorocarbons similar to that of chloroform. /fluorocarbons/
Abosrption of fluorocarbons is much lower after oral ingestion (35-48 times) than after inhalation. ... The lung generally has the highest fluorocarbon concentrations on autopsy. /Fluorocarbons/
Although fluorocarbons cause cardiac sensitization in certain animal species, rapid elimination prevents the development of cardiotoxic concentrations from aerosol bronchodilator use except at exceedingly high doses (12 to 24 doses in 2 minutes). /Fluorocarbons/
Fluorocarbon compounds are lipid-soluble and thus are generally well absorbed through lung. Absorption after ingestion is 35 to 48 times lower than after inhalation. ... Fluorocarbons are eliminated by way of lung. /fluorocarbon compounds/
A series of new hypervalentiodinereagents based on the 1,3‐dihydro‐3,3‐dimethyl‐1,2‐benziodoxole and 1,2‐benziodoxol‐3‐(1H)‐one scaffolds, which contain a functionalized tetrafluoroethyl group, have been prepared, characterized, and used in synthetic applications. Their corresponding electrophilic fluoroalkylation reactions with various sulfur, oxygen, phosphorus, and carbon‐centered nucleophiles
[EN] HYPERVALENT IODINE CF2CF2X REAGENTS AND THEIR USE<br/>[FR] RÉACTIFS CF2CF2X À BASE D'IODE HYPERVALENT ET LEUR UTILISATION
申请人：ETH ZUERICH
公开号：WO2016019475A1
公开（公告）日：2016-02-11
A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for fluoroethylation of compounds carrying a reactive group. A preferred compound carrying a reactive group is cystein in any environment such as peptide targets.
Synthesis and Characterization of Phenylphosphine Oxide Containing Perfluorocyclobutyl Aromatic Ether Polymers for Potential Space Applications
作者：Jianyong Jin、Dennis W. Smith,、Chris M. Topping、S. Suresh、Shengrong Chen、Stephen H. Foulger、Norman Rice、Jon Nebo、Bob H. Mojazza
DOI：10.1021/ma035241g
日期：2003.12.1
(PPO) containingperfluorocyclobutyl (PFCB) polymers has been developed for potential use as multifunctional materials in space environments. The reaction of p-BrArOCFCF2 (for Ar = phenyl and biphenyl) with tert-butyllithium affords the lithium reagent smoothly below −20 °C. Subsequent substitution with phenylphosphonic dichloride provides the first bis(trifluorovinyl ether) monomers containing the PPO
ELECTRON-TRANSFER INTERACTION BETWEEN THE COMPLEXED SILVER(I) CATION AND RUTHENIUM ATOM IN POLYOXA[<i>n</i>]- AND 1,<i>n</i>-DIOXATHIA[<i>n</i>]RUTHENOCENOPHANES
作者：Sadatoshi Akabori、Yoichi Habata、Masaru Sato
DOI：10.1246/cl.1985.1063
日期：1985.7.5
Polyoxa[n]ruthenocenophanes and 1,n-dioxathia[n]ruthenocenophanes were prepared. The complexes of the ruthenocenophanes with transition metal cations were isolated. The 1H-NMR and electronic spectra of the silver(I) ion-complexed 1,4,7,10,13,16-hexaoxa[16]ruthenocenophane suggested the presence of strong electron-transfer interaction between the complexed silver(I) cation and the ruthenium atom of the ruthenocene nucleus.
The present invention related to compounds of Formula (I) or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4 and R5 are as described herein. The invention further relates to compositions comprising said compounds, to methods of controlling weeds using said compositions, and to the use of Compounds of Formula (I) as a herbicide.
