potassium hydrogenoxalate | 127-95-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物的盐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: potassium hydrogenoxalate
• 英文别名: Potassium hydrogen oxalate；potassium;2-hydroxy-2-oxoacetate
• CAS: 127-95-7
• 化学式: C₂HO₄*K
• 分子量: 128.126
• InChiKey: JMTCDHVHZSGGJA-UHFFFAOYSA-M

物化性质

• 熔点：
  >300°C
• 密度：
  2.088 [HAW93]
• 溶解度：
  溶于二甲基亚砜
• LogP：
  -4.961
• 物理描述：
  Potassium hydrogen oxalate is an odorless white solid. Sinks in water. (USCG, 1999)
• 颜色/状态：
  Monoclinic, colorless crystals
• 味道：
  BITTER, SHARP TASTE
• 分解：
  DANGEROUS; WHEN HEATED TO DECOMPOSITION, THEY EMIT TOXIC AND IRRITATING FUMES. /OXALATES/
• 稳定性/保质期：
  易溶于水，但不能从水中重新结晶。

计算性质

• 辛醇/水分配系数(LogP)：
  -6.4
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  1
• 氢受体数：
  4

ADMET

毒理性

• 人类毒性摘录

症状学：1. 咽喉、食道和胃部有烧灼性疼痛。暴露的粘膜区域几乎立即变为不透明的白色……嘴唇和面部无腐蚀作用。2. 呕吐（常带有血或呈咖啡渣外观），剧烈的烧灼性疼痛，严重的腹泻。/草酸盐/

SYMPTOMATOLOGY: 1. BURNING PAIN IN THROAT, ESOPHAGUS, & STOMACH. EXPOSED AREAS OF MUCOUS MEMBRANE TURN ALMOST IMMEDIATELY OPAQUE WHITE...NO CORROSIVE ACTIONS ON LIPS & FACE. 2. VOMITING (OFTEN BLOODY OR WITH COFFEE GROUND APPEARANCE), INTENSE BURNING PAIN, SEVERE PURGING. /OXALATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

症状学：3. 脉搏变得虚弱、不规则，有时感觉不到。出现低血压和心血管衰竭的常见迹象。/草酸盐/

SYMPTOMATOLOGY: 3. PULSE BECOMES WEAK, IRREGULAR, & SOMETIMES IMPERCEPTIBLE. HYPOTENSION & USUAL SIGNS OF CARDIOVASCULAR COLLAPSE APPEAR. /OXALATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

症状学：4. 如果死亡被延迟几个小时，可能会发展出神经或神经肌肉症状：头痛，肌肉痉挛...手足抽搐，有时伴有惊厥，昏迷，死亡。5. 肾脏损伤，表现为少尿、蛋白尿和血尿，可能会持续数周。/草酸盐/

SYMPTOMATOLOGY: 4. IF DEATH IS DELAYED FOR A FEW HR, NERVOUS OR NEUROMUSCULAR SYMPTOMS DEVELOP: HEADACHE, MUSCLE CRAMPS...TETANY, SOMETIMES CONVULSIONS, STUPOR, COMA, & DEATH. 5. RENAL DAMAGE, AS EVIDENCED BY OLIGURIA, ALBUMINURIA, & HEMATURIA MAY PERSIST FOR WK. /OXALATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

草酸的可溶性盐具有与草酸本身基本相同的毒性。/草酸盐盐/

SOLUBLE SALTS OF OXALIC ACID HAVE ESSENTIALLY SAME TOXICITY AS ACID. /OXALATE SALTS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

症状包括精神沉郁和食欲丧失。头部低垂，动物不愿与群体一起。在急性中毒情况下...流涎和鼻涕，逐渐虚弱，呼吸急促且浅，最终倒地不起。...肺可能呈深红色并充满血液...出现点状或较大的出血点... /草酸/

...SYMPTOMS INCLUDE DULLNESS & LOSS OF APPETITE. HEAD IS LOWERED & ANIMAL IS UNWILLING TO KEEP WITH FLOCK. WITH ACUTE POISONING...SALIVATION & NASAL DISCHARGE WITH PROGRESSIVE WEAKNESS, RAPID SHALLOW BREATHING & COLLAPSE. ... LUNGS MAY BE DARK RED & FILLED WITH BLOOD... PETECHIAL OR LARGER HEMORRHAGES... /OXALIC ACID/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

草酸盐在肠道中被很好地吸收...在体内不被燃烧，而是与组织和血液中的钙结合，并通过肾脏排出体外。/草酸盐/

OXALATES ARE WELL ABSORBED FROM INTESTINE...NOT BURNED IN BODY, BUT UNITE WITH TISSUE & BLOOD CALCIUM & ARE EXCRETED BY KIDNEY. /OXALATES/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(b)
• 包装等级：
  III
• 危险类别：
  6.1(b)
• 危险品运输编号：
  2811
• 危险性防范说明：
  P280
• 危险性描述：
  H302,H312
• 储存条件：
  室温

SDS

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Section 1. Chemical Product and Company Identification
Potassium binoxalate Catalog
YY289, P1187
Common Name/
Number(s).
Trade Name
CAS# 127-95-7
Manufacturer
RTECS RO3600000
SPECTRUM CHEMICAL MFG. CORP.
TSCA TSCA 8(b) inventory:
Potassium binoxalate
Commercial Name(s) Not available.
CI# Not available.
Synonym Not available.
IN CASE OF EMERGENCY
Not available.
Chemical Name
Chemical Family Not available. CALL [phone]
C2HKO4
Chemical Formula
SPECTRUM CHEMICAL MFG. CORP.

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Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3)
Name CAS # % by Weight
1) Potassium binoxalate 127-95-7 100
Toxicological Data Potassium binoxalate
on Ingredients LD50: Not available.
LC50: Not available.

---

Section 3. Hazards Identification
Potential Acute Health Effects Very hazardous in case of eye contact (irritant), of ingestion. Hazardous in case of skin contact (irritant), of
inhalation. Inflammation of the eye is characterized by redness, watering, and itching.
Potential Chronic Health Very hazardous in case of eye contact (irritant), of ingestion.
Effects Hazardous in case of skin contact (irritant), of inhalation.
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance is toxic to kidneys, lungs, mucous membranes.
Repeated or prolonged exposure to the substance can produce target organs damage.
Potassium binoxalate

---

Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,
keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Skin Contact After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
Wash contaminated clothing before reusing.
Serious Skin Contact Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
Inhalation Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation Not available.
Ingestion Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion Not available.

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
These products are carbon oxides (CO, CO2). Some metallic oxides.
Products of Combustion
Fire Hazards in Presence of Not available.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Not available.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards

---

Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Potassium binoxalate

---

Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. In case of
insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the
label when possible. Avoid contact with skin and eyes
Storage Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
and away from strong oxidizing agents.

---

Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Hygroscopic powder.) Odor Odorless.
Taste Bitter. Sharp biting.
128.13 g/mole
Molecular Weight
Color White.
pH (1% soln/water) Not available.
Boiling Point Not available.
Melting Point Decomposes.
Critical Temperature Not available.
Specific Gravity 2.088 (Water = 1)
Not applicable.
Vapor Pressure
Vapor Density Not available.
Volatility Not available.
Odor Threshold Not available.
Water/Oil Dist. Coeff. Not available.
Not available.
Ionicity (in Water)
Dispersion Properties See solubility in water.
Partially soluble in cold water.
Solubility
Insoluble in methanol, diethyl ether.

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Section 10. Stability and Reactivity Data
Stability The product is stable.
Instability Temperature Not available.
Conditions of Instability Not available.
Incompatibility with various Not available.
substances
Potassium binoxalate
Non-corrosive in presence of glass.
Corrosivity
Special Remarks on Not available.
Reactivity
Special Remarks on Not available.
Corrosivity
No.
Polymerization

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Section 11. Toxicological Information
Routes of Entry Eye contact. Inhalation. Ingestion.
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans The substance is toxic to kidneys, lungs, mucous membranes.
Other Toxic Effects on Very hazardous in case of ingestion.
Humans
Hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on Not available.
Chronic Effects on Humans
Special Remarks on other Not available.
Toxic Effects on Humans

---

Section 12. Ecological Information
Not available.
Ecotoxicity
BOD5 and COD Not available.
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The products of degradation are more toxic.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation

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Section 13. Disposal Considerations
Waste Disposal

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Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Identification Not applicable.
Special Provisions for Not applicable.
Transport
Potassium binoxalate
DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: Potassium binoxalate
Federal and State
Regulations
California
Proposition 65
Warnings
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
WHMIS (Canada) CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
Other Classifications
DSCL (EEC) R38- Irritating to skin.
R41- Risk of serious damage to eyes.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Potassium binoxalate

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

简介

草酸氢钾（PBO），又称“重草酸钾”或“酸性草酸钾”，是一种无色结晶体，易溶于水但无法从水中进行重结晶。它是最常见的草酸氢盐阴离子盐之一，可通过氢氧化钾与草酸反应制得。

应用

草酸氢钾广泛应用于制革、织物整理剂、媒染剂，金属抛光、防锈和处理剂，有机化工原料，催化剂以及化学分析的基准物和分析试剂。此外，它还用于感光材料的制备。

制备方法

将12.6克二水合草酸（0.1摩尔）溶解于300毫升水中，同时将18.4克一水合草酸钾（0.1摩尔）溶解于100毫升水中。然后，在3℃下将草酸钾的水溶液缓慢加入到草酸的水溶液中，并在0℃条件下放置24小时。析出的晶体即为草酸氢钾一水合物。

用途

草酸氢钾主要用于容量分析，用作标定标准溶液的基准物质；同时，它还可以用于去除墨水渍点和清洁金属、木材等表面。

反应信息

• 作为反应物：
  描述：

  potassium hydrogenoxalate 在 basic beryllium carbonate 作用下， 以 not given 为溶剂， 生成
  参考文献：
  名称：

  Debray, H., Annales de Chimie et de Physique, 1855, vol. 44, p. 35

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 作用下， 450.0~480.0 ℃ 、24.82 MPa 条件下， 生成 potassium hydrogenoxalate
  参考文献：
  名称：

  Matignon; Faurholt, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, vol. 179, p. 273

  摘要：

  DOI：

文献信息

• Catalytic Conversion Of Alcohols To Aldehydes Or Ketones
  申请人：Carter Melvin K.

  公开号：US20140046098A1

  公开（公告）日：2014-02-13

  Catalytic reactions are taught using air or oxygen for oxidative chemical conversion of primary alcohols to aldehydes and for secondary alcohols to ketones in a vapor phase at ambient pressure. The catalytic process converts ethanol to acetaldehyde, n-propanol to propionaldehyde, 2-propanol to acetone, and other alcohols to aldehydes and ketones. The catalysts are based on molecular strings of di-, tri- and/or poly-groups of transition metal complexes possessing a specific degree of symmetry. Laboratory results have demonstrated [vanadium (II)] 2 , [chromium (II)] 2 , [manganese (II)] 2 , [cobalt (II)] 2 oxalate and symmetric transition metal catalysts to be effective for oxidative catalytic conversion of primary alcohols to products comprising related aldehydes and secondary alcohols to products comprising ketones.

  催化反应使用空气或氧气在气相中将一次醇氧化转化为醛，将二次醇氧化转化为酮，并且在常压下进行。催化过程将乙醇转化为乙醛，正丙醇转化为丙醛，异丙醇转化为丙酮，以及其他醇类转化为醛和酮。催化剂基于过渡金属络合物的二、三和/或多群分子链，具有特定程度的对称性。实验室结果表明，[钒(II)]2、[铬(II)]2、[锰(II)]2、[钴(II)]2草酸盐和对称过渡金属催化剂对一次醇氧化催化转化为相关醛类产品和二次醇氧化转化为酮类产品是有效的。
• Rhodium(III) compounds with 1,10-phenanthroline and 2,2′-bipyridyl
  作者：E.D. McKenzie、R.A. Plowman

  DOI：10.1016/0022-1902(70)80463-8

  日期：1970.1

  Various compounds containing the species [Rh chelate X4]−, [Rh chelate (H2O)X3], [Rh chelate2X2]+, and [Rh chelate3]3+ (where chelate = 1,10-phenanthroline and 2,2′-bipyridyl, and XCl− or Br−) are described. In aqueous solution the step-wise addition of the ligands occurs: (RhX3)aq. + L → mono-chelate → Rh2chelate3X6 → bis-chelate → tris-chelate.

  包含[Rh螯合物X 4 ] -，[Rh螯合物（H 2 O）X 3 ]，[Rh螯合物2 X 2 ] +和[Rh螯合物3 ] 3+（其中螯合物= 1,10-菲咯啉和2,2'-联吡啶，和XCl -或Br - ）中有所描述。在水溶液中逐步发生配体的添加：（RhX 3）aq。+ L→单螯合物→Rh 2螯合物3 X 6 →双螯合物→tris螯合物
• Design, Synthesis, and Biological Features of Platinum(II) Complexes with Rigid Steric Hindrance
  作者：Zhimei Wang、Haiyan Yu、Shaohua Gou、Feihong Chen、Lei Fang

  DOI：10.1021/acs.inorgchem.6b00361

  日期：2016.5.2

  line. Among them, complex 1 had superior cytotoxic activity against A549, HCT-116, MCF-7, SGC7901, and SGC7901/CDDP cancer cell lines. The DNA binding assay is of further special interest, as an unusual monofunctional binding mode was found, due to the introduction of a rigid substituted aromatic ring in the 1R,2R-diaminocyclohexane framework as steric hindrance. The linkage of complex 1 with DNA was

  设计并合成了一系列带有N-单取代的1 R，2 R-二氨基环己烷的甲氧基取代的苄基作为载体配体的铂（II）配合物。发现以氯阴离子为离去基团的新制备的化合物对测试的癌细胞系包括顺铂耐药细胞系具有非常高的活性。尽管它们具有抗肿瘤细胞的功效，但是它们对人正常的肝细胞系也显示出低毒性。其中，复杂1对A549，HCT-116，MCF-7，SGC7901和SGC7901 / CDDP癌细胞系具有优异的细胞毒活性。由于发现在1 R，2 R-二氨基环己烷骨架中引入了刚性取代的芳香环作为空间位阻，因此发现了一种异常的单功能结合模式，因此DNA结合测定法引起了人们的特别关注。配合物1与DNA的连接稳定且对亲核攻击不敏感。此外，包括细胞摄取，凝胶电泳，细胞凋亡和细胞周期以及蛋白质印迹分析在内的研究已经提供了对该化合物高效潜力的认识。
• The thermal decomposition of metal complexes—I
  作者：W.W. Wendlandt、T.D. George、K.V. Krishnamurty

  DOI：10.1016/0022-1902(61)80415-6

  日期：1961.12

  of a number of cobalt (III) amine complexes, several of them containing the carbonate ion in the coordination sphere, and several metal oxalato complexes were studied by the methods of TGA and DTA. The thermal stability of the carbonate complexes, as determined by the above methods, was: [Co(NH3)4CO3]NO3 < [Co(tn)2CO3]Cl < [Co(pn)2CO3]Cl < [Co(en)2CO3]Cl. For the metal oxalato complexes, the thermal

  通过TGA和DTA方法研究了许多钴（III）胺配合物的热分解，其中一些在配位体中包含碳酸根离子，以及几种金属草酸酯配合物。通过上述方法确定的碳酸盐配合物的热稳定性为：[Co（NH 3）4 CO 3 ] NO 3 <[Co（tn）2 CO 3 ] Cl <[Co（pn）2 CO 3 ]。 Cl <[Co（en）2 CO 3 ] Cl。对于金属草酸酯络合物，基于DTA脱水峰最大值的热稳定性顺序为：K 3 [Cr（C 2 O 4）3 ]·3H 2 O
• Kehrmann, F., Chemische Berichte, 1886, vol. 19, p. 3101 - 3101
  作者：Kehrmann, F.

  DOI：——

  日期：——

表征谱图