Stereochemistry-Activity Relationships in Olfaction. Odorants containing a proton donor/proton acceptor unit
作者:G�nther Ohloff、Wolfgang Giersch
DOI:10.1002/hlca.19800630109
日期:1980.1.23
A novel class of odorants is described where the odor is associated with the interaction of two functional groups, one being an H-donor (AH function), and the other an H-acceptor (B function). Generally, odor occurs only if the distance between the two structural elements (AH/B system) is less than 3 Å. Bifunctional derivatives of the p-menthane and iridane series served as models for deriving this
作者:Siu Min Tan、Anthony C. Willis、Michael N. Paddon‐Row、Michael S. Sherburn
DOI:10.1002/anie.201510925
日期:2016.2.24
combining the powerful twofold diene‐transmissive Diels–Alder chemistry of [3]dendralenes with the simplicity of enamine formation. On mixing at ambient temperature, a simple dienal condenses with a primary or secondary amine to generate the enamine, a 1‐amino‐[3]dendralene in situ, and this participates as a double diene in a sequence of two Diels–Alder events with separate dienophiles. Overall, four