Vinylogous hydrazone strategy for the organocatalytic alkylation of heteroaromatic derivatives
作者:Beata Łukasik、Justyna Kowalska、Sebastian Frankowski、Łukasz Albrecht
DOI:10.1039/d1cc01923f
日期:——
umpolung approach for the asymmetric Friedel–Crafts-type alkylation of electron-poor heteroaromatic systems has been developed. It is based on the vinylogous reactivity of hydrazones derived from heteroaromatic aldehydes. The donating effect of the hydrazone moiety can be efficiently transferred over the heteroaromatic system activating it towards an asymmetric Friedel–Crafts reaction with α,β-unsaturated
Thermoregulated phase-transfer iridium nanoparticle catalyst: highly selective hydrogenation of the CO bond for α,β-unsaturated aldehydes and the CC bond for α,β-unsaturated ketones
作者:Wenjiang Li、Yanhua Wang、Pu Chen、Min Zeng、Jingyang Jiang、Zilin Jin
DOI:10.1039/c6cy01137c
日期:——
thermoregulated ligand Ph2P(CH2CH2O)22CH3-stabilized iridium nanoparticles exhibited a totally different orientation for the hydrogenation of unsaturated carbonyl compounds, namely, highly selective hydrogenation of the CO bond for α,β-unsaturated aldehydes and the CC bond for α,β-unsaturatedketones.
Nickel-catalyzed Conjugate Addition of Arylboron Reagents to α,β-Unsaturated Carbonyl Compounds with the Aid of a Catalytic Amount of an Alkyne
作者:Eiji Shirakawa、Yuichi Yasuhara、Tamio Hayashi
DOI:10.1246/cl.2006.768
日期:2006.7
Alkynes in combination with a catalytic amount of a nickel complex were found to catalyze the conjugate addition of arylboron reagents to α,β-unsaturated carbonyl compounds, where use of an optical...
A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids
作者:Tanja Knaus、Vasilis Tseliou、Luke D. Humphreys、Nigel S. Scrutton、Francesco G. Mutti
DOI:10.1039/c8gc01381k
日期:——
optimised biocatalytic oxidation runs in phosphate buffer at pH 8.5 and at 40 °C. From a set of sixty-one aliphatic, aryl-aliphatic, benzylic, hetero-aromatic and bicyclic aldehydes, fifty were converted with elevated yield (up to >99%). The exceptions were a few ortho-substituted benzaldehydes, bicyclic heteroaromaticaldehydes and 2-phenylpropanal. In all cases, the expected carboxylic acid was shown
Regio- and <i>Trans</i>-Selective Ni-Catalyzed Coupling of Butadiene, Carbonyls, and Arylboronic Acids to Homoallylic Alcohols under Base-Free Conditions
作者:Yu-Qing Li、Guang Chen、Shi-Liang Shi
DOI:10.1021/acs.orglett.1c00488
日期:2021.4.2
We herein report a Ni-catalyzed three-component coupling of 1,3-butadiene, carbonylcompounds, and arylboronic acids as a general synthetic approach to 1,4-disubstituted homoallylic alcohols, an important class of compounds, which have previously not been straightforward to access. The reaction occurs efficiently using a Ni(cod)2 catalyst without any external base and ligand at ambient temperature