4-(3-Oxo-3-phenylprop-1-enyl)benzenesulfonyl chloride | 7454-09-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-(3-Oxo-3-phenylprop-1-enyl)benzenesulfonyl chloride
• CAS: 7454-09-3
• 化学式: C₁₅H₁₁ClO₃S
• 分子量: 306.77
• InChiKey: QJOPDPKVYXDCAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-Oxo-3-phenylprop-1-enyl)benzenesulfonyl chloride 在 氯化亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.5h， 生成 methyl ((4-(3-oxo-3-phenylprop-1-en-1-yl)phenyl)sulfonyl)-L-leucinate
  参考文献：
  名称：

  Novel Communication: Some Novel Organosulfur Amino Acid Derivatives as Potential Antiparasitic Agents

  摘要：

  The chalones 1, 14, and 26 reacted with chlorosulfonic acid to give corresponding sulfonyl chlorides 2, 15, and 27, which condensed with nucleophiles to give amino acid derivatives 3-6, 16-18, and 28-31. Some of the corresponding methyl esters 7, 8, 19-20, and 32-34 were prepared. Hydrazinolysis of these methyl esters yielded hydrazides 9, 10, 21, 22, and 35-36. Coupling reaction of some amino acid derivatives with amino acid methyl ester hydrochloride in THF-Et3N using dicyclohexylcarbodiimide method furnished the desired dipeptide methyl ester's 11-13, 23-25, and 37-38. Some spectroscopic evidence including NMR spectra analysis are briefly discussed.

  DOI：

  10.1080/10426500601142221
• 作为产物：
  描述：

  苯亚甲基苯乙酮 在 氯磺酸 作用下， 反应 504000.0h， 以75%的产率得到4-(3-Oxo-3-phenylprop-1-enyl)benzenesulfonyl chloride
  参考文献：
  名称：

  Novel Communication: Some Novel Organosulfur Amino Acid Derivatives as Potential Antiparasitic Agents

  摘要：

  The chalones 1, 14, and 26 reacted with chlorosulfonic acid to give corresponding sulfonyl chlorides 2, 15, and 27, which condensed with nucleophiles to give amino acid derivatives 3-6, 16-18, and 28-31. Some of the corresponding methyl esters 7, 8, 19-20, and 32-34 were prepared. Hydrazinolysis of these methyl esters yielded hydrazides 9, 10, 21, 22, and 35-36. Coupling reaction of some amino acid derivatives with amino acid methyl ester hydrochloride in THF-Et3N using dicyclohexylcarbodiimide method furnished the desired dipeptide methyl ester's 11-13, 23-25, and 37-38. Some spectroscopic evidence including NMR spectra analysis are briefly discussed.

  DOI：

  10.1080/10426500601142221

文献信息

• Novel Communication: Some Novel Organosulfur Amino Acid Derivatives as Potential Antiparasitic Agents
  作者：Ragab A. El-Sayed

  DOI：10.1080/10426500601142221

  日期：2007.3.15

  The chalones 1, 14, and 26 reacted with chlorosulfonic acid to give corresponding sulfonyl chlorides 2, 15, and 27, which condensed with nucleophiles to give amino acid derivatives 3-6, 16-18, and 28-31. Some of the corresponding methyl esters 7, 8, 19-20, and 32-34 were prepared. Hydrazinolysis of these methyl esters yielded hydrazides 9, 10, 21, 22, and 35-36. Coupling reaction of some amino acid derivatives with amino acid methyl ester hydrochloride in THF-Et3N using dicyclohexylcarbodiimide method furnished the desired dipeptide methyl ester's 11-13, 23-25, and 37-38. Some spectroscopic evidence including NMR spectra analysis are briefly discussed.