[7-Hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-5-yl] dihydrogen phosphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: [7-Hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-5-yl] dihydrogen phosphate
• 英文别名: [7-hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-5-yl] dihydrogen phosphate
• 化学式: C₁₅H₁₁O₈P
• 分子量: 350.22
• InChiKey: GEOVLGYUKCZSEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• COMPOSITIONS COMPRISING GENISTEIN PHOSPHATES FOR TREATING THE LOSS OF BONE MASS
  申请人：Hughes Biotechnology Co., Ltd.

  公开号：EP3494973A1

  公开（公告）日：2019-06-12

  The present invention provides use of an effective amount of genistein phosphate conjugate for the preparation of a composition for treatment or prevention of a disease associated with a decrease in bone mass, wherein the composition is administering to a subject in need of such treatment. The present invention also provides use of the genistein phosphate conjugate for the preparation of a composition for improving bone architecture and bio-mechanical strength of bone. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.

  本发明提供了有效量的染料木素磷酸酯轭合物用于制备治疗或预防与骨量下降有关的疾病的组合物的用途，其中该组合物用于需要此类治疗的受试者。本发明还提供了染料木素磷酸酯共轭物用于制备改善骨结构和骨的生物机械强度的组合物的用途。本发明向需要此类治疗的受试者施用包含有效量磷酸染料木素共轭物的组合物，可有效提高口服生物利用度，从而减轻更年期妇女的症状和并发症风险，增加骨矿物质含量、骨密度和骨的生物机械强度，减缓骨质疏松症。
• Method for treatment or prevention of a disease associated with a decrease in bone mass and method of improving bone architecture and bio mechanical strength of bone
  申请人：HUGHES BIOTECHNOLOGY CO., LTD

  公开号：US10881634B2

  公开（公告）日：2021-01-05

  The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.

  本发明提供了一种治疗或预防与骨量下降有关的疾病的方法，包括向需要这种治疗的受试者施用一种包含有效量的基因素磷酸酯共轭物的组合物。本发明还提供了一种改善骨结构和骨的生物机械强度的方法，包括向需要这种治疗的受试者施用一种包含有效量的基因素磷酸轭合物的组合物。本发明向需要此类治疗的受试者施用包含有效量的染料木素磷酸酯共轭物的组合物，可有效提高口服生物利用度，从而减轻更年期妇女的症状和并发症风险，增加骨矿物质含量、骨密度和骨的生物力学强度，减缓骨质疏松症。
• COMPOSITIONS COMPRISING 7-O-GENISTEIN PHOSPHATE FOR USE IN THE TREATMENT OF PRIMARY OSTEOPOROSIS
  申请人：Hughes Biotechnology Co., Ltd.

  公开号：EP3494973B1

  公开（公告）日：2021-07-28
• METHOD FOR TREATMENT OR PREVENTION OF A DISEASE ASSOCIATED WITH A DECREASE IN BONE MASS AND METHOD OF IMPROVING BONE ARCHITECTURE AND BIO-MECHANICAL STRENGTH OF BONE
  申请人：HUGHES BIOTECHNOLOGY CO., LTD

  公开号：US20190175545A1

  公开（公告）日：2019-06-13

  The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.