申请人：Novogen Research PTY Limited
公开号：US20030018060A1
公开（公告）日：2003-01-23
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R
1
is H, or R
A
CO where R
A
is C
1-10
alkyl or an amino acid, R
2
is H, OH, or OR
B
where R
B
is an amino acid, or COR
A
where R
A
is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R
3
is H, COR
A
where R
A
is as previously defined, CO
2
R
C
where R
C
is C
1-10
alkyl, or COR
B
where R
B
is as previously defined, R
4
is H, COR
D
where R
D
is H, OH, C
1-10
alkyl or an amino acid, CO
2
R
C
where R
C
is as previously defined, COR
E
where R
E
is H, C
1-10
alkyl or an amino acid, COOH, COR
C
where R
C
is as previously defined, or CONHR
E
where R
E
is as previously defined, R
5
is H, CO
2
R
C
where R
C
is as previously defined, or COR
C
OR
E
where R
C
and R
E
are as previously defined, and where the two R
5
groups are attached to the same group they are the same or different, R
6
is H or hydroxy C
1-10
aIkyl, X is preferably O, but may be N or S, and Y is (h) where R
7
is H, or C
1-10
alky).
本文描述了一种治疗方法、组合物和食品，其中包含了一般式（I）所描述的异黄酮化合物，其中Z为H，R1为H或RACO，其中RA为C1-10烷基或氨基酸，R2为H、OH或ORB，其中RB为氨基酸，或CORA，其中RA如上定义，W为H，A为H或OH，B选自（a）、（b）、（c），或W为H，A和B共同形成六元环，选自（d），或W、A和B与它们相关联的基团共同形成（e），或W和A与它们相关联的基团共同形成（f），B为（g），其中R3为H，或CORA，其中RA如上定义，CO2RC，其中RC为C1-10烷基，或CORB，其中RB如上定义，R4为H，CORD，其中RD为H、OH、C1-10烷基或氨基酸，或CO2RC，其中RC如上定义，CORE，其中RE为H、C1-10烷基或氨基酸，COOH，CORC，其中RC如上定义，或CONHRE，其中RE如上定义，R5为H，CO2RC，其中RC如上定义，或CORCORE，其中RC和RE如上定义，如果两个R5基团连接到同一基团，则它们相同或不同，R6为H或羟基C1-10烷基，X最好为O，但也可以为N或S，Y为（h），其中R7为H或C1-10烷基。
