2-(3-cyano-5-(2,4-difluorophenyl)-4,5-dimethylfuran-2(5H)-ylidene)malononitrile | 383124-89-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(3-cyano-5-(2,4-difluorophenyl)-4,5-dimethylfuran-2(5H)-ylidene)malononitrile
• 英文别名: 2-dicyanomethylene-3-cyano-4,5-dimethyl-5-[2',4'-difluorophenyl]-2,5-dihydrofuran；2-[3-Cyano-5-(2,4-difluorophenyl)-4,5-dimethylfuran-2-ylidene]propanedinitrile
• CAS: 383124-89-8
• 化学式: C₁₆H₉F₂N₃O
• 分子量: 297.264
• InChiKey: UHMIWSTYMDDUHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  80.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-hydroxy-3-[2',4'-difluorophenyl]-2-butanone 、 丙二腈 在 乙醇锂 作用下， 以 四氢呋喃 为溶剂， 以37.9%的产率得到2-(3-cyano-5-(2,4-difluorophenyl)-4,5-dimethylfuran-2(5H)-ylidene)malononitrile
  参考文献：
  名称：

  COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX

  摘要：

  揭示了与GPR35及/或GPR35-hERG信号复合物在病理生理上相关的疾病的预防和/或治疗的组合物和方法。例如，揭示了用于预防和/或治疗与GPR35在受试者中病理生理相关的疾病的化合物。这些化合物具有以下公式(I)、(II)或(III)：

  公开号：

  US20120022116A1

文献信息

• ELECTRO-OPTIC POLYMER
  申请人：NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY

  公开号：US20210032228A1

  公开（公告）日：2021-02-04

  The present invention provides an electro-optic polymer (EO polymer) comprising an electro-optic molecule (EO molecule) and a base polymer. The EO polymer of the present invention has good performance over the entire optical communication wavelength range and therefore can preferably be used for the production of optical modulators, optical switches, optical transceivers, optical phased arrays, LiDAR (light detection and ranging) devices, electric field sensors, terahertz wave generators and detectors, etc.

  本发明提供了一种电光聚合物（EO聚合物），包括电光分子（EO分子）和基础聚合物。本发明的EO聚合物在整个光通信波长范围内具有良好的性能，因此可以优选用于光调制器、光开关、光收发器、光子阵列、激光雷达（LiDAR）、电场传感器、太赫兹波发生器和探测器等的生产。
• ELECTRO-OPTICAL POLYMER
  申请人：National Institute of Information and Communications Technology

  公开号：EP3748420A1

  公开（公告）日：2020-12-09

  The present invention provides an electro-optic polymer (EO polymer) comprising an electro-optic molecule (EO molecule) and a base polymer, the EO molecule having a structure in which a π-electron donor and a π-electron acceptor are conjugated via a π-conjugation bridge, the EO polymer having an electro-optic coefficient (EO coefficient) of 30 pm/V or more and a figure of merit (FOM) of 10 × 10-6 cm/dBV or more in an entire optical communication wavelength range of 1260 nm to 1625 nm, the FOM being defined by the following formula: FOM=n3ramaxλ10−6cm/dBV wherein n indicates a refractive index, r indicates an EO coefficient, amax indicates a maximum absorption coefficient in a wavelength range of interest, and λ indicates a wavelength. The EO polymer of the present invention has good performance over the entire optical communication wavelength range and therefore can preferably be used for the production of optical modulators, optical switches, optical transceivers, optical phased arrays, LiDAR (light detection and ranging) devices, electric field sensors, terahertz wave generators and detectors, etc.

  本发明提供了一种电光聚合物（EO 聚合物），该聚合物由电光分子（EO 分子）和基体聚合物组成，EO 分子具有π电子供体和π电子受体通过π共轭桥共轭的结构、在 1260 纳米至 1625 纳米的整个光通信波长范围内，EO 聚合物的电光系数（EO 系数）达到或超过 30 pm/V，优点系数（FOM）达到或超过 10 × 10-6 cm/dBV，FOM 由下式定义：FOM=n3ramaxλ10-6cm/dBV 其中，n 表示折射率，r 表示环氧乙烷系数，amax 表示相关波长范围内的最大吸收系数，λ 表示波长。 本发明的环氧乙烷聚合物在整个光通信波长范围内都具有良好的性能，因此可优先用于生产光调制器、光开关、光收发器、光相控阵、LiDAR（光探测和测距）装置、电场传感器、太赫兹波发生器和探测器等。
• MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF
  申请人：Corning Incorporated

  公开号：EP2519236A2

  公开（公告）日：2012-11-07
• MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF
  申请人：Deng Huayun

  公开号：US20120329865A1

  公开（公告）日：2012-12-27

  Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R 1 , R 2 , R 3 , R 6 , R 5 , and R 4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
• [EN] MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF<br/>[FR] MOLÉCULES ASSOCIÉES À DES CANAUX IONIQUES HERG ET LEUR UTILISATION
  申请人：CORNING INC

  公开号：WO2011081970A2

  公开（公告）日：2011-07-07

  Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R1, R2, R3, R6, R5, and R4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.