maculaniol | 43230-74-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: maculaniol
• 英文别名: 1-Hydroxy-friedelan；(1S,4S,4aR,6aS,6aS,6bR,8aR,12aR,14aR,14bR)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-1-ol
• CAS: 43230-74-6
• 化学式: C₃₀H₅₂O
• 分子量: 428.742
• InChiKey: IGDXQFIAOCIECM-YBTMEFRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  maculaniol 在 chromium trioxide-pyridine complex 作用下， 以 吡啶 为溶剂， 反应 24.0h， 以16.2 mg的产率得到friedelan-1-one
  参考文献：
  名称：

  Pentacyclic triterpenes from the fungus, Leptosphaeria maculans

  摘要：

  Fermented broth of the fungus, Leptosphaeria maculans gave two pentacyclic triterpenoid compounds. Based on spectral analysis these compounds were identified as maculaniol and 3-alpha-hydroxy-urs-18,20-dien-28-oic acid.

  DOI：

  10.1016/s0031-9422(00)95208-7
• 作为产物：
  描述：

  friedelane-1,3-dione 在 platinum(IV) oxide 吡啶 、 氢气 、 sodium ethanolate 、 肼 作用下， 反应 2.0h， 生成 maculaniol
  参考文献：
  名称：

  Salacia prinoides DC的三萜

  摘要：

  从Salacia prinoides DC的根皮中提取。（Celastraceae），已分离出六个紧密相关的三萜，P，Q，R，S，T和V。已经证明它们是1，3-二酮丁二烯衍生物。这些化合物中，所述的结构1，10，39，33，11和12，已建立的光谱的基础以及降解证据。

  DOI：

  10.1016/s0040-4020(01)83157-4

文献信息

• Active fraction of a polar solvent extract from the latex of euphorbiaceae plants
  申请人：AMAZONIA FITOMEDICAMENTOS LTDA.

  公开号：US10143673B2

  公开（公告）日：2018-12-04

  The present invention generally refers to an active fraction of an extract of the latex of plants from the family Euphorbiaceae in a polar solvent, as well as of one or more compounds contained therein, as well as the use of said fraction and/or said compounds, particularly in the treatment of cancer. The invention also refers to compositions comprising said active fraction and/or said compounds, as well as their use for the treatment of diseases concerning cell proliferation/angiogenesis, particularly cancer.

  本发明一般是指大戟科植物在极性溶剂中的胶乳提取物的活性部分，以及其中所含的一种或多种化合物，以及所述部分和/或所述化合物的用途，尤其是在治疗癌症中的用途。本发明还涉及包含所述活性成分和/或所述化合物的组合物，以及它们在治疗细胞增殖/血管生成相关疾病，尤其是癌症方面的用途。
• ACTIVE FRACTION OF A POLAR SOLVENT EXTRACT FROM THE LATEX OF EUPHORBIACEAE PLANTS
  申请人：Amazônia Fitomedicamentos Ltda.

  公开号：EP1901758B1

  公开（公告）日：2013-05-01
• [EN] ACTIVE FRACTION OF A POLAR SOLVENT EXTRACT FROM THE LATEX OF EUPHORBIACEAE PLANTS<br/>[FR] FRACTION ACTIVE D'EXTRAITS PAR SOLVANT POLAIRE DU LATEX D'EUPHORBIACEAE
  申请人：AMAZONIA FITOMEDICAMENTOS LTDA

  公开号：WO2007000618A1

  公开（公告）日：2007-01-04

  [EN] The present invention generally refers to an active fraction of an extract of the latex of plants from the family Euphorbiaceae in a polar solvent, as well as of one or more compounds contained therein, as well as the use of said fraction and/or said compounds, particularly in the treatment of cancer. The invention also refers to compositions comprising said active fraction and/or said compounds, as well as their use for the treatment of diseases concerning cell proliferation/angiogenesis, particularly cancer.
  [FR] L'invention porte sur la fraction active d'extraits par solvant polaire du latex de plante de la famille Euphorbiaceae, ainsi que sur un ou plusieurs composés y étant contenus et sur l'utilisation de ladite fraction et/ou desdits composés en en particulier pour le traitement du cancer. L'invention porte également sur des compositions comprenant ladite fraction active et/ou lesdits composés, et sur leur utilisation pour le traitement de maladies liées à la prolifération cellulaire et à l'angiogenèse, et en particulier du cancer.
• Triterpenes of Salacia prinoides DC
  作者：B.S. Joshi、V.N. Kamat、N. Viswanathan

  DOI：10.1016/s0040-4020(01)83157-4

  日期：1973.1

  From the root bark of Salacia prinoides DC. (Celastraceae), six closely related triterpenes, P, Q, R, S, T and V have been isolated. These have been shown to be 1,3-diketofriedelane derivatives. The structures of these compounds, 1, 10, 39, 33, 11 and 12, have been established on the basis of spectroscopic as well as degradative evidence.

  从Salacia prinoides DC的根皮中提取。（Celastraceae），已分离出六个紧密相关的三萜，P，Q，R，S，T和V。已经证明它们是1，3-二酮丁二烯衍生物。这些化合物中，所述的结构1，10，39，33，11和12，已建立的光谱的基础以及降解证据。
• Pentacyclic triterpenes from the fungus, Leptosphaeria maculans
  作者：Jagroop S. Dahiya

  DOI：10.1016/s0031-9422(00)95208-7

  日期：1991.1

  Fermented broth of the fungus, Leptosphaeria maculans gave two pentacyclic triterpenoid compounds. Based on spectral analysis these compounds were identified as maculaniol and 3-alpha-hydroxy-urs-18,20-dien-28-oic acid.